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CD38 Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636834

CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability; cyclic ADP-ribose, NAADP+, and ADP-ribose 3. CD38 is expressed in B and T… More details

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Product Overview

Online Datasheet in PDF
Product Name
CD38, Active Protein
Full Product Name
CD38, Recombinant, Human (Acute Lymphoblastic Leukemia Cells Antigen, ADP Ribosyl Cyclase, CADPr Hydrolase 1, Cyclic ADP Ribose Hydrolase, Ecto Nicotinamide Adenine Dinucleotide Glycohydrolase, I19 (Mouse), Lymphocyte Differentiation Antigen)
Product Gene Name
CD38 active protein
Form/Format
Supplied as a liquid in 25mM MES, 0.15M NaCl, pH 6.5.
Purity/Purification
Highly Purified
95%, as determined by SDS-PAGE and visualized by silver stain.
Preparation and Storage
-70 degree C
Molecular Weight
The purified, secreted rhCD38 has an N-terminal sequence of V43PRWRQQWSG. The 264 amino acid protein predicts a molecular mass of 31 kD and migrates with the apparent molecular mass of approximately 43 kD in SDS-PAGE.
Chromosome Location
Chromosome: 4; NC_000004.11 (15779921..15850706). Location: 4p15
OMIM
107270
3D Structure
ModBase 3D Structure for P28907
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Activity
Measured by its ability to convert the substrate nicotinamide guanine dinucleotide (NGD +) to cyclic GDP-ribose. The cyclic GDP-ribose is measured by fluorescence at excitation and emission wavelengths of 300 nm and 410 nm, respectively2. The specific activity, measured with 100 M substrate and 100 ng enzyme in 100 L of 50 mM MES, pH 6.5, at room temperature is > 2,500 pmoles/min/ g.
Endotoxin Level
< 1.0 EU per 1 g of the protein as determined by the LAL method.
Reconstitution
Centrifuge the vial before opening to recover entire contents of the vial. Due to possible sublimation during storage, the buffer volume may decrease over time, however, the product is sold by mass and the amount of protein will remain constant. To ensure quantitative recovery, we suggest the stock solution be made in the original vial.

Storage and Stability:
Samples are stable for up to six months at -70 degree C in a manual defrost freezer after the date of receipt. After receiving, this protein can be aliquoted and stored at above temperature for up to six months without a significant loss of activity. Avoid repeated freeze-thaw cycles.

Product Categories/Family for CD38 active protein

Molecular Biology; MB-CD Markers

Other Notes

Small volumes of CD38 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD38 purchase

MBS636834 is an active protein targeting CD38. Also known as CD38, Recombinant, Human (Acute Lymphoblastic Leukemia Cells Antigen, ADP Ribosyl Cyclase, CADPr Hydrolase 1, Cyclic ADP Ribose Hydrolase, Ecto Nicotinamide Adenine Dinucleotide Glycohydrolase, I19 (Mouse), Lymphocyte Differentiation Antigen).

Additional Details

NCBI/Uniprot data below describe general gene information for CD38. It may not necessarily be applicable to this product.

NCBI GI #
1911103
NCBI GeneID
952
NCBI Accession #
BAA18966.1
UniProt Primary Accession #
P28907
UniProt Secondary Accession #
O00121; O00122; Q96HY4
UniProt Related Accession #
P28907
NCBI Official Full Name
CD38
NCBI Official Synonym Full Names
CD38 molecule
NCBI Official Symbol
CD38
NCBI Official Synonym Symbols
T10
UniProt Protein Name
ADP-ribosyl cyclase 1
UniProt Synonym Protein Names
Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10
Protein Family
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
UniProt Gene Name
CD38
UniProt Synonym Gene Names
cADPr hydrolase 1
UniProt Entry Name
CD38_HUMAN
NCBI Protein Information
ADP-ribosyl cyclase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase; cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

NCBI Summary for CD38

CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling. [provided by RefSeq, Jul 2008]

UniProt Comments for CD38

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Apoptosis; Cell surface; Lyase; EC 3.2.2.6; Hydrolase; Membrane protein, integral; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.4.99.20

Chromosomal Location of Human Ortholog: 4p15

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane; nucleus

Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity

Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of vasoconstriction; response to hypoxia; positive regulation of B cell proliferation; response to progesterone stimulus; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
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Research Articles on CD38

1. The frequency of CD38high antibody-secreting cells (ASCs) is increased during the acute phase of hepatitis A virus (HAV) infection. Substantial numbers of ASCs are non-HAV-specific and dominantly secrete IgM.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD38 active protein

 Reference Product  PubMed Publications
 CD4 active protein  >1038 publications with CD38 and CD4
 CD27 active protein  >206 publications with CD38 and CD27
 IL6 active protein  >24 publications with CD38 and IL6
 LCK active protein  >8 publications with CD38 and LCK
 BST1 active protein  >1 publications with CD38 and BST1

Pathways associated with CD38 active protein

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram

Diseases associated with CD38 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1777 publications with CD38 and Neoplasms
 Cardiovascular Diseases Antibodies  >393 publications with CD38 and Cardiovascular Diseases
 Inflammation Antibodies  >204 publications with CD38 and Inflammation
 Necrosis Antibodies  >185 publications with CD38 and Necrosis
 Nervous System Diseases Antibodies  >88 publications with CD38 and Nervous System Diseases
 Anemia Antibodies  >86 publications with CD38 and Anemia
 Liver Diseases Antibodies  >84 publications with CD38 and Liver Diseases
 Neoplasms, Experimental Antibodies  >65 publications with CD38 and Neoplasms, Experimental
 Carcinoma Antibodies  >57 publications with CD38 and Carcinoma
 Disease Models, Animal Antibodies  >56 publications with CD38 and Disease Models, Animal

Organs/Tissues associated with CD38 active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3427 publications with CD38 and Blood
 Bone Marrow Antibodies  >1287 publications with CD38 and Bone Marrow
 Lymph Node Antibodies  >263 publications with CD38 and Lymph Node
 Liver Antibodies  >201 publications with CD38 and Liver
 Lymph Antibodies  >194 publications with CD38 and Lymph
 Spleen Antibodies  >149 publications with CD38 and Spleen
 Muscle Antibodies  >119 publications with CD38 and Muscle
 Tonsil Antibodies  >108 publications with CD38 and Tonsil
 Brain Antibodies  >105 publications with CD38 and Brain
 Pharynx Antibodies  >105 publications with CD38 and Pharynx
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