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Complement C5a Mouse (C5AR1) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636890

C5a is a potent chemoattractant and anaphylatoxin that acts on all classes of leukocytes and on many other cell types including endothelial, smooth muscle, kidney, liver, and neural cells. In addition to its proinflammatory effects, C5a has been shown to… More details

$1515 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Complement C5a Mouse (C5AR1), Recombinant Protein
Full Product Name
Complement C5a, Recombinant Mouse
Product Gene Name
C5AR1 recombinant protein
Sequence
MRGSHHHHHH GSDYDIPTTE NLYFQGGSNL HLLRQKIEEQ AAKYKHSVPK KCCYDGARVN FYETCEERV< br>ARVTIGP LCIRAFNECC TIANKIRKES PHKPVQLGR.
Host
E Coli
Form/Format
Supplied aa a lyophilized powder from 0.005% Tween80+2 mM reduced L-glutathion+0.2mM oxidised L-gluthation+0.1M Tris-CI buffer, pH 8.0. Reconstitute with 500uL sterile ddH20. Further dilute with PBS.
Purity/Purification
Purified
Concentration
~0.176 mg/mL (after reconstitution) (lot specific)
Preparation and Storage
Lyophilized and reconstituted products may be stored at -20°C. Stable for 6 months after receipt at -20°C.Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
12kD
Chromosome Location
Chromosome: 19; NC_000019.9 (47813104..47825327). Location: 19q13.3-q13.4
OMIM
113995
3D Structure
ModBase 3D Structure for P21730

Product Categories/Family for C5AR1 recombinant protein

Molecular Biology; MB-Complement

Other Notes

Small volumes of C5AR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C5AR1 purchase

MBS636890 is a recombinant protein targeting C5AR1. Also known as Complement C5a, Recombinant Mouse. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for C5AR1. It may not necessarily be applicable to this product.

NCBI GI #
14290436
NCBI GeneID
728
NCBI Accession #
AAH08982.1
UniProt Primary Accession #
P21730
UniProt Related Accession #
P21730
NCBI Official Full Name
Complement component 5a receptor 1
NCBI Official Synonym Full Names
complement component 5a receptor 1
NCBI Official Symbol
C5AR1
NCBI Official Synonym Symbols
C5A; C5AR; C5R1; CD88
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 1
UniProt Synonym Protein Names
C5a anaphylatoxin chemotactic receptor
Protein Family
C5a anaphylatoxin chemotactic receptor
UniProt Gene Name
C5AR1
UniProt Synonym Gene Names
C5AR; C5R1; C5a-R; C5aR
UniProt Entry Name
C5AR1_HUMAN
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 1; C5a-R; C5a ligand; C5a anaphylatoxin receptor; complement component 5 receptor 1

UniProt Comments for C5AR1

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: cell surface; apical part of cell; basolateral plasma membrane; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function: complement component C5a binding; complement component C5a receptor activity; C5a anaphylatoxin receptor activity

Biological Process: neutrophil chemotaxis; sensory perception of chemical stimulus; organ regeneration; activation of MAPK activity; apoptosis; response to lipopolysaccharide; signal transduction; chemotaxis; cell proliferation in hindbrain; mRNA transcription from RNA polymerase II promoter; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; phospholipase C activation; response to peptidoglycan; cellular defense response; immune response; negative regulation of neuron apoptosis; inflammatory response; positive regulation of epithelial cell proliferation
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Research Articles on C5AR1

1. C5aR-C5L2 homodimerization versus heterodimerization contribute to differential responses obtained following ASP vs C5a stimulation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C5AR1 recombinant protein

 Reference Product  PubMed Publications
 C3AR1 recombinant protein  >2 publications with C5AR1 and C3AR1
 FPR1 recombinant protein  >1 publications with C5AR1 and FPR1
 GNAI2 recombinant protein  >1 publications with C5AR1 and GNAI2

Pathways associated with C5AR1 recombinant protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram

Diseases associated with C5AR1 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >33 publications with C5AR1 and Inflammation
 Immune System Diseases Antibodies  >15 publications with C5AR1 and Immune System Diseases
 Autoimmune Diseases Antibodies  >11 publications with C5AR1 and Autoimmune Diseases
 Cardiovascular Diseases Antibodies  >6 publications with C5AR1 and Cardiovascular Diseases
 Lung Diseases Antibodies  >5 publications with C5AR1 and Lung Diseases
 Necrosis Antibodies  >3 publications with C5AR1 and Necrosis
 Neoplasms Antibodies  >3 publications with C5AR1 and Neoplasms
 Lung Injury Antibodies  >3 publications with C5AR1 and Lung Injury
 Shock, Septic Antibodies  >3 publications with C5AR1 and Shock, Septic
 Nervous System Diseases Antibodies  >2 publications with C5AR1 and Nervous System Diseases

Organs/Tissues associated with C5AR1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >42 publications with C5AR1 and Blood
 Bone Marrow Antibodies  >4 publications with C5AR1 and Bone Marrow
 Intestine Antibodies  >4 publications with C5AR1 and Intestine
 Placenta Antibodies  >3 publications with C5AR1 and Placenta
 Uterus Antibodies  >1 publications with C5AR1 and Uterus
 Prostate Antibodies  >1 publications with C5AR1 and Prostate
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