NAGLU Active Protein

Name: NAGLU Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS638019
Price: 1245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS638019

Human lysosomal A-N-acetylglucosaminidase is a hydrolase that catalyses the removal of terminal A-N-acetylglucosamine residues from heparan sulfate and heparin. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as… More details

$1245 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NAGLU, Active Protein

Full Product Name

NAGLU, Recombinant, Human (Alpha-N-acetylglucosaminidase, N-acetyl-alpha-glucosaminidase, NAG, UFHSD1)

Product Gene Name

Naglu active protein

Form/Format

Supplied as a liquid in 25mM Tris, 150mM sodium chloride. BSA free.

Purity/Purification

Highly Purified
>95% by SDS-PAGE under reducing conditions

Concentration

0.88 mg/ml (lot specific)

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months after receipt at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~81kD

Chromosome Location

Chromosome: 11; NC_000077.6 (101070094..101077672). Location: 11 D; 11

3D Structure

ModBase 3D Structure for P54802

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Source

Recombinant, CHO cells

Specific Activity

>900pmol/min/ug

Biological Activity

Measured by its ability to hydrolyze 4-Nitrophenyl-N-acetyl-a-D-glucosaminide.

Endotoxin Level

<1EU/1ug (LAL)

Product Categories/Family for Naglu active protein

Molecular Biology; MB-Enzymes

Other Notes

Small volumes of Naglu active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Naglu purchase

MBS638019 is an active protein targeting Naglu. Also known as NAGLU, Recombinant, Human (Alpha-N-acetylglucosaminidase, N-acetyl-alpha-glucosaminidase, NAG, UFHSD1).

Additional Details

NCBI/Uniprot data below describe general gene information for Naglu. It may not necessarily be applicable to this product.

NCBI GI #

2660688

NCBI GeneID

27419

NCBI Accession #

AAB88084.1

UniProt Primary Accession #

P54802

NCBI Official Full Name

Naglu

NCBI Official Synonym Full Names

alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)

NCBI Official Symbol

Naglu

Protein Family

Alpha-N-acetylglucosaminidase

NCBI Protein Information

alpha-N-acetylglucosaminidase; N-acetyl-glucosaminidase; alpha-N-acetylglucosaminidase, lysosomal

UniProt Comments for Naglu

NAGLU: Involved in the degradation of heparan sulfate. Defects in NAGLU are the cause of mucopolysaccharidosis type 3B (MPS3B); also known as Sanfilippo syndrome B. MPS3B is a form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life.

Protein type: Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.50; Hydrolase

Molecular Function: alpha-N-acetylglucosaminidase activity

Biological Process: locomotor rhythm; retinal rod cell development; lysosome organization and biogenesis; inner ear receptor cell development; cerebellar Purkinje cell layer development; middle ear morphogenesis

Research Articles on Naglu

1. In the 1-h test, MPS IIIB mice were hyperactive, with increased rapid exploratory behaviour and reduced immobility time.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Naglu active protein

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Degradation Pathway antibodies	Glycosaminoglycan Degradation Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
HS-GAG Degradation Pathway antibodies	HS-GAG Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram
Heparan Sulfate Degradation Pathway antibodies	Heparan Sulfate Degradation Pathway Diagram
Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies	Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram