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VANGL2 cDNA Clone – Cdna Clone Image:40006965 (Human)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1278892

MBS1278892 is a cDNA clone targeting VANGL2. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
VANGL2, cDNA Clone
Full Product Name
VANGL2 cDNA Clone
Product Gene Name
VANGL2 cdna clone
Sequence
ATGGACACCG AGTCCCAGTA CTCGGGCTAT TCCTACAAGT CGGGCCACTC CCGCAGCTCC CGCAAGCACA GGGACCGCCG GGACCGACAC CGCTCTAAGA GTCGAGATGG GGGCCGAGGG GACAAGTCGG TGACAATCCA GGCTCCCGGG GAGCCCCTGC TGGACAATGA GTCCACACGA GGGGATGAGC GGGATGACAA CTGGGGGGAA ACGACGACAG TAGTAACGGG CACCTCAGAG CACAGCATCT CCCATGATGA CCTCACACGC ATCGCCAAGG ACATGGAGGA CAGTGTCCCT CTGGACTGCT CCCGTCACCT GGGTGTGGCA GCGGGGGCCA CCCTGGCACT GCTGTCTTTC CTCACGCCTC TGGCCTTCCT GCTGCTGCCC CCACTGCTGT GGCGGGAGGA GCTGGAGCCT TGCGGGACGG CCTGCGAGGG CCTCTTCATC TCTGTCGCCT TCAAGCTGCT CATCCTGCTA CTGGGCAGCT GGGCTCTGTT CTTCCGCCGG CCCAAGGCCT CGCTGCCCCG CGTCTTTGTG CTGCGTGCCC TGCTTATGGT GCTGGTTTTC CTGCTCGTGG TCTCCTACTG GCTCTTCTAT GGTGTGCGCA TCCTGGATGC TCGGGAGCGC AGCTACCAGG GCGTGGTGCA GTTCGCCGTG TCGCTGGTGG ACGCCCTTCT TTTCGTGCAC TACCTGGCCG TGGTCCTGCT GGAGCTGCGC CAGCTCCAGC CTCAGTTCAC GCTCAAGGTC GTGCGCTCCA CCGACGGCGC CAGCCGCTTC TACAACGTTG GCCATCTCAG CATCCAGCGC GTGGCAGTGT GGATCCTGGA GAAGTATTAC CATGACTTCC CTGTCTACAA CCCTGCCCTC CTCAACCTGC CCAAGTCCGT CCTGGCCAAG AAAGTGTCTG GCTTCAAGGT GTATTCCCTC GGAGAGGAAA ACAGCACCAA CAACTCCACT GGCCAGTCTC GGGCTGTGAT TGCAGCGGCA GCTCGGAGGC GGGACAACAG TCACAATGAG TACTACTATG AGGAGGCTGA GCATGAGCGA AGGGTGCGCA AGAGGAGGGC CAGGCTTGTA GTGGCGGTGG AGGAGGCCTT CACTCACATT AAGCGGCTGC AGGAAGAGGA GCAGAAGAAC CCCAGGGAGG TGATGGACCC CCGGGAGGCA GCCCAAGCCA TCTTTGCATC CATGGCCCGT GCCATGCAGA AGTACCTTCG GACCACCAAG CAGCAGCCCT ACCACACCAT GGAGAGCATC CTGCAGCACC TTGAATTCTG CATCACGCAT GACATGACGC CCAAGGCCTT CTTGGAGCGA TACTTGGCGG CTGGACCTAC CATCCAGTAC CACAAGGAAC GCTGGCTGGC CAAACAGTGG ACATTGGTGA GCGAGGAGCC GGTGACCAAC GGCCTCAAGG ATGGCATCGT TTTCCTCTTA AAACGCCAGG ACTTCAGCCT GGTGGTCAGC ACCAAGAAGG TCCCATTCTT CAAACTCTCC GAGGAATTTG TGGATCCCAA GTCACACAAG TTTGTCATGA GGCTGCAGTC TGAGACCTCA GTGTGA
Molecular Weight
59,714 Da
OMIM
182940
Vector
pENTR223.1
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of VANGL2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VANGL2. It may not necessarily be applicable to this product.

NCBI GI #
146147397
NCBI GeneID
57216
NCBI Accession #
BC103920
UniProt Secondary Accession #
Q5T212; D3DVE9
UniProt Related Accession #
Q9ULK5
NCBI Official Full Name
Homo sapiens cDNA clone IMAGE:40006965
NCBI Official Synonym Full Names
VANGL planar cell polarity protein 2
NCBI Official Symbol
VANGL2
NCBI Official Synonym Symbols
LPP1; LTAP; STB1; STBM; STBM1
UniProt Protein Name
Vang-like protein 2
UniProt Synonym Protein Names
Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family
Vang-like protein
UniProt Gene Name
VANGL2
UniProt Synonym Gene Names
KIAA1215; STB1
UniProt Entry Name
VANG2_HUMAN
NCBI Protein Information
vang-like protein 2

NCBI Summary for VANGL2

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
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UniProt Comments for VANGL2

VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane

Molecular Function: protein binding

Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis

Disease: Neural Tube Defects
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Research Articles on VANGL2

1. VANGL2 is overexpressed in basal breast cancers. It is involved in the proliferative signal cascade of the VANGL2-SQSTM1-JNK pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with VANGL2 cdna clone

 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway NetPath antibodies  Wnt Signaling Pathway NetPath Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram

Diseases associated with VANGL2 cdna clone

 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >43 publications with VANGL2 and Neural Tube Defects
 Nervous System Diseases Antibodies  >33 publications with VANGL2 and Nervous System Diseases
 Nervous System Malformations Antibodies  >29 publications with VANGL2 and Nervous System Malformations
 Cardiovascular Diseases Antibodies  >9 publications with VANGL2 and Cardiovascular Diseases
 Neoplasms Antibodies  >7 publications with VANGL2 and Neoplasms
 Kidney Diseases Antibodies  >2 publications with VANGL2 and Kidney Diseases
 Edema Antibodies  >2 publications with VANGL2 and Edema
 Brain Diseases Antibodies  >2 publications with VANGL2 and Brain Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with VANGL2 and Craniofacial Abnormalities
 Intestinal Neoplasms Antibodies  >1 publications with VANGL2 and Intestinal Neoplasms

Organs/Tissues associated with VANGL2 cdna clone

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >45 publications with VANGL2 and Embryonic Tissue
 Brain Antibodies  >23 publications with VANGL2 and Brain
 Muscle Antibodies  >8 publications with VANGL2 and Muscle
 Lung Antibodies  >7 publications with VANGL2 and Lung
 Eye Antibodies  >6 publications with VANGL2 and Eye
 Skin Antibodies  >5 publications with VANGL2 and Skin
 Uterus Antibodies  >2 publications with VANGL2 and Uterus
 Prostate Antibodies  >2 publications with VANGL2 and Prostate
 Connective Tissue Antibodies  >2 publications with VANGL2 and Connective Tissue
 Intestine Antibodies  >1 publications with VANGL2 and Intestine
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