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Rsk1, Active, Rat (RPS6KA1) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS638214

Recombinant full-length rat RSK1 (residues 1-end), containing additional N-terminal 6His and HA (YPYDVPDYA) tags. Expressed in baculovirus in Sf21 insect cells More details

$1205 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Rsk1, active, Rat (Rps6ka1), Active Protein
Full Product Name
Rsk1, active, Recombinant, Rat (Ribosomal S6 Kinase 1, RSK-1, MAP Kinase-activated Protein Kinase 1a, MAPK-activated Protein Kinase 1a, MAPKAP kinase 1a, Mapkapk1a, MAPKAPK-1a, 90kD Rbosomal Protein S6 Kinase 1, p90RSK1, p90-RSK 1, p90S6K, Ribosomal Prote
Product Gene Name
Rps6ka1 active protein
Product Synonym Names
Rsk1, active, Recombinant, Rat (Ribosomal S6 Kinase 1, RSK-1, MAP Kinase-activated Protein Kinase 1a, MAPK-activated Protein Kinase 1a, MAPKAP kinase 1a, Mapkapk1a, MAPKAPK-1a, 90kD Rbosomal Protein S6 Kinase 1, p90RSK1, p90-RSK 1, p90S6K, Ribosomal Prote
Form/Format
Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 300mM sodium chloride, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol.
Purity/Purification
Highly Purified
~95%. Purified using Ni2+/NTA-agarose. Activated with p42 MAPK and PDK1, and repurified by glutathione-, heparin-, and Ni2+/NTA-agarose chromatographies.
Preparation and Storage
Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
89.9kD
Chromosome Location
Chromosome: 5; NC_005104.3 (155760609..155805563, complement). Location: 5q36
3D Structure
ModBase 3D Structure for Q63531
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Specific Activity
~4000-5000U/mg, where one unit of RSK1 activity is defined as 1nmol phosphate incorporated into 30uM Rsktide per minute at 30 degree C with a final ATP concentration of 100uM.

Product Categories/Family for Rps6ka1 active protein

Molecular Biology; MB-Protein Kinases; Ribosomal

Other Notes

Small volumes of Rps6ka1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Rps6ka1 purchase

MBS638214 is an active protein targeting Rps6ka1. Also known as Rsk1, active, Recombinant, Rat (Ribosomal S6 Kinase 1, RSK-1, MAP Kinase-activated Protein Kinase 1a, MAPK-activated Protein Kinase 1a, MAPKAP kinase 1a, Mapkapk1a, MAPKAPK-1a, 90kD Rbosomal Protein S6 Kinase 1, p90RSK1, p90-RSK 1, p90S6K, Ribosomal Prote.

Additional Details

NCBI/Uniprot data below describe general gene information for Rps6ka1. It may not necessarily be applicable to this product.

NCBI GI #
13592065
NCBI GeneID
81771
NCBI Accession #
NP_112369.1
UniProt Primary Accession #
Q63531
UniProt Related Accession #
Q63531
GenBank Nucleotide #
NM_031107.1
NCBI Official Full Name
ribosomal protein S6 kinase alpha-1
NCBI Official Synonym Full Names
ribosomal protein S6 kinase polypeptide 1
NCBI Official Symbol
Rps6ka1
UniProt Protein Name
Ribosomal protein S6 kinase alpha-1
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 1; p90-RSK 1; p90RSK1; p90S6K; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; Ribosomal S6 kinase 1
Protein Family
Ribosomal protein S6 kinase
UniProt Gene Name
Rps6ka1
UniProt Synonym Gene Names
Mapkapk1a; Rsk1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1
UniProt Entry Name
KS6A1_RAT
NCBI Protein Information
ribosomal protein S6 kinase alpha-1; RSK-1; p90S6K; p90RSK1; pp90RSK1; MAPKAPK1A; p90-RSK 1; MAPKAPK-1a; S6K-alpha 1; S6K-alpha-1; MAPKAP kinase 1a; ribosomal S6 kinase 1; S6 protein kinase (Rsk-1); MAPK-activated protein kinase 1a; 90 kDa ribosomal protein S6 kinase 1; MAP kinase-activated protein kinase 1a

NCBI Summary for Rps6ka1

catalyzes the phosphorylation of ETS transcription factor ER81 and other transcription factors [RGD, Feb 2006]

UniProt Comments for Rps6ka1

p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Translation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; AGC group; RSK family; RSK subfamily

Cellular Component: cytoplasm; ribosome; spindle; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; caspase inhibitor activity; magnesium ion binding; protein serine/threonine/tyrosine kinase activity; ribosomal protein S6 kinase activity; transcription factor binding; ATP binding

Biological Process: positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; protein amino acid phosphorylation; negative regulation of apoptosis
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Research Articles on Rps6ka1

1. novel mechanisms by which active RSK1 accumulates in the nucleus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Rps6ka1 active protein

 Reference Product  PubMed Publications
 Mtor active protein  >78 publications with Rps6ka1 and Mtor
 Mapk1 active protein  >29 publications with Rps6ka1 and Mapk1
 Mapk3 active protein  >27 publications with Rps6ka1 and Mapk3
 Tsc2 active protein  >6 publications with Rps6ka1 and Tsc2
 Igf1 active protein  >3 publications with Rps6ka1 and Igf1
 Atf4 active protein  >2 publications with Rps6ka1 and Atf4

Pathways associated with Rps6ka1 active protein

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 EGFR1 Signaling Pathway antibodies  EGFR1 Signaling Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Kit Receptor Signaling Pathway antibodies  Kit Receptor Signaling Pathway Diagram
 Long-term Potentiation Pathway antibodies  Long-term Potentiation Pathway Diagram
 Long-term Potentiation Pathway antibodies  Long-term Potentiation Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with Rps6ka1 active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with Rps6ka1 and Neoplasms
 Inflammation Antibodies  >13 publications with Rps6ka1 and Inflammation
 Hypertrophy Antibodies  >11 publications with Rps6ka1 and Hypertrophy
 Disease Models, Animal Antibodies  >10 publications with Rps6ka1 and Disease Models, Animal
 Liver Diseases Antibodies  >10 publications with Rps6ka1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >7 publications with Rps6ka1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >7 publications with Rps6ka1 and Breast Neoplasms
 Hyperplasia Antibodies  >6 publications with Rps6ka1 and Hyperplasia
 Adenocarcinoma Antibodies  >5 publications with Rps6ka1 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >5 publications with Rps6ka1 and Cell Transformation, Neoplastic

Organs/Tissues associated with Rps6ka1 active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >24 publications with Rps6ka1 and Brain
 Liver Antibodies  >23 publications with Rps6ka1 and Liver
 Heart Antibodies  >19 publications with Rps6ka1 and Heart
 Lung Antibodies  >8 publications with Rps6ka1 and Lung
 Connective Tissue Antibodies  >7 publications with Rps6ka1 and Connective Tissue
 Embryonic Tissue Antibodies  >5 publications with Rps6ka1 and Embryonic Tissue
 Pancreas Antibodies  >3 publications with Rps6ka1 and Pancreas
 Kidney Antibodies  >3 publications with Rps6ka1 and Kidney
 Eye Antibodies  >1 publications with Rps6ka1 and Eye
 Prostate Antibodies  >1 publications with Rps6ka1 and Prostate
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