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AMER1 Antibody – Rabbit Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641195

WTX (Wilms' tumor gene on the X chromosome) is a developmentally regulated gene with a potentially important role in kidney development (1). Functional studies of WTX suggest that it acts as a tumor suppressor gene in renal cells by promoting B-catenin… More details

$815 / 0.1 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
WTX (AMER1), Monoclonal Antibody
Full Product Name
WTX, NT (Protein FAM123B, Wilms Tumor Gene On The X Chromosome Protein, FAM123B)
Product Gene Name
anti-AMER1 antibody
Product Synonym Names
Anti -WTX, NT (Protein FAM123B, Wilms Tumor Gene On The X Chromosome Protein, FAM123B)
Clonality
Monoclonal
Isotype
IgG
Clone Number
D38E5
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, <0.02% sodium azide, 50% glycerol.
Purity/Purification
Supernatant
Supernatant
Specificity
Recognizes transfected levels of total human WTX.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
124,029 Da
Chromosome Location
Chromosome: X; NC_000023.10 (63404997..63425624, complement). Location: Xq11.2
OMIM
300373
3D Structure
ModBase 3D Structure for Q5JTC6
Immunogen
Recombinant protein specific to the amino terminus of human WTX.

Product Categories/Family for anti-AMER1 antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-AMER1 antibody
Western Blot (WB)
Application Notes for anti-AMER1 antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 1:1000

Western Blot (WB) of anti-AMER1 antibody

Western blot analysis of extracts from HeLa cells, untransfected or transfected with a contruct overexpressing human WTX, using MBS641195.
Rabbit Anti-AMER1 Monoclonal Antibody – Cat# MBS641195

Other Notes

Small volumes of anti-AMER1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMER1 purchase

MBS641195 is an antibody targeting AMER1. Also known as WTX, NT (Protein FAM123B, Wilms Tumor Gene On The X Chromosome Protein, FAM123B). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AMER1. It may not necessarily be applicable to this product.

NCBI GI #
121556878
NCBI GeneID
139285
NCBI Accession #
ABM60755.1
UniProt Primary Accession #
Q5JTC6
UniProt Secondary Accession #
Q8N885; A2IB86
UniProt Related Accession #
Q5JTC6
NCBI Official Full Name
WTX
NCBI Official Synonym Full Names
APC membrane recruitment protein 1
NCBI Official Symbol
AMER1
NCBI Official Synonym Symbols
WTX; OSCS; FAM123B; RP11-403E24.2
UniProt Protein Name
APC membrane recruitment protein 1
UniProt Synonym Protein Names
Protein FAM123B; Wilms tumor gene on the X chromosome protein
Protein Family
APC membrane recruitment protein
UniProt Gene Name
AMER1
UniProt Synonym Gene Names
FAM123B; WTX; Amer1
UniProt Entry Name
AMER1_HUMAN
NCBI Protein Information
APC membrane recruitment protein 1; protein FAM123B; Wilms tumor on the X; family with sequence similarity 123B; Wilms tumor gene on the X chromosome protein; adenomatous polyposis coli membrane recruitment 1

NCBI Summary for AMER1

The protein encoded by this gene upregulates trancriptional activation by the Wilms tumor protein and interacts with many other proteins, including CTNNB1, APC, AXIN1, and AXIN2. Defects in this gene are a cause of osteopathia striata with cranial sclerosis (OSCS). [provided by RefSeq, May 2010]

UniProt Comments for AMER1

WTX: a peripheral membrane protein on the cytoplasmic side that shuttles between nucleus and cytoplasm. Detected in nuclear paraspeckles that are found close to splicing speckles. Enhances trancription activation by WT1. Promotes CTNNB1 ubiquitination and degradation. Antagonizes Wnt and CTNNB1 signaling. Inactivated in approximately one-third of Wilms tumors. Detected in fetal and adult kidney, brain and spleen. Involved in kidney development. Interacts with CTNNB1, AXIN1, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in a complex containing CTNNB1, APC, AXIN1 and AXIN2. Two alternatively spliced human isoforms have been reported.

Chromosomal Location of Human Ortholog: Xq11.2

Cellular Component: plasma membrane; nucleus; cytosol

Molecular Function: protein binding; phosphatidylinositol-4,5-bisphosphate binding; beta-catenin binding

Biological Process: Wnt receptor signaling pathway

Disease: Osteopathia Striata With Cranial Sclerosis
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Research Articles on AMER1

1. Data indicate that osteopathia striata congenita with cranial sclerosis (OSCS) iscaused by germline deletions of in the X-linked gene WTX (FAM123B, AMER1).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMER1 antibody

 Reference Product  PubMed Publications
 KEAP1 antibody  >2 publications with AMER1 and KEAP1
 AXIN1 antibody  >2 publications with AMER1 and AXIN1
 BTRC antibody  >1 publications with AMER1 and BTRC

Pathways associated with anti-AMER1 antibody

 Products by Pathway  Pathway Diagram
 Beta-catenin Phosphorylation Cascade Pathway antibodies  Beta-catenin Phosphorylation Cascade Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Degradation Of Beta-catenin By The Destruction Complex Pathway antibodies  Degradation Of Beta-catenin By The Destruction Complex Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Wnt Pathway antibodies  Signaling By Wnt Pathway Diagram

Diseases associated with anti-AMER1 antibody

 Disease Name  Pubmed Publications
 Congenital, Hereditary, and Neonatal Diseases and Abnormalities Antibodies  >32 publications with AMER1 and Congenital, Hereditary, and Neonatal Diseases and Abnormalities
 Osteopathia striata cranial sclerosis Antibodies  >5 publications with AMER1 and Osteopathia striata cranial sclerosis
 Aneuploidy Antibodies  >3 publications with AMER1 and Aneuploidy
 Nervous System Malformations Antibodies  >1 publications with AMER1 and Nervous System Malformations

Organs/Tissues associated with anti-AMER1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >25 publications with AMER1 and Kidney
 Lung Antibodies  >2 publications with AMER1 and Lung
 Heart Antibodies  >1 publications with AMER1 and Heart
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