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SKA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641659

Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle… More details

$915 / 0.05 mg +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
SKA1, Polyclonal Antibody
Full Product Name
SKA1, CT (Spindle and Kinetochore-associated Protein 1, C18orf24)
Product Gene Name
anti-SKA1 antibody
Product Synonym Names
Anti -SKA1, CT (Spindle and Kinetochore-associated Protein 1, C18orf24)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human SKA1. Species sequence homology: Mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
29,484 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (47901392..47920538). Location: 18q21.1
3D Structure
ModBase 3D Structure for Q96BD8
Immunogen
Synthetic peptide corresponding to human SKA1 at C-terminal conjugated to KLH.

Product Categories/Family for anti-SKA1 antibody

Antibodies; Abs to DNA/RNA Translation
Applications Tested/Suitable for anti-SKA1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SKA1 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-SKA1 antibody

Human Brain, Cerebellum: Formalin-Fixed, Paraffin- Embedded (FFPE)
Rabbit Anti-SKA1 Polyclonal Antibody – Cat# MBS641659

Immunohistochemistry (IHC) of anti-SKA1 antibody

Human Brain, Cortex: Formalin- Fixed, Paraffin-Embedded (FFPE)
Rabbit Anti-SKA1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641659

Western Blot (WB) of anti-SKA1 antibody

Western blot analysis of SKA1 in A549 cell lysate with SKA1 antibody at (A) 0.5 and (B) 1ug/ml.
Rabbit Anti-SKA1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS641659

Other Notes

Small volumes of anti-SKA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SKA1 purchase

MBS641659 is an antibody targeting SKA1. Also known as SKA1, CT (Spindle and Kinetochore-associated Protein 1, C18orf24). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SKA1. It may not necessarily be applicable to this product.

NCBI GI #
88014625
NCBI GeneID
220134
NCBI Accession #
NP_001034624.1
UniProt Primary Accession #
Q96BD8
UniProt Secondary Accession #
B2R9Y6; B4E0P4
UniProt Related Accession #
Q96BD8
GenBank Nucleotide #
NM_001039535.2
NCBI Official Full Name
spindle and kinetochore-associated protein 1
NCBI Official Synonym Full Names
spindle and kinetochore associated complex subunit 1
NCBI Official Symbol
SKA1
NCBI Official Synonym Symbols
C18orf24
UniProt Protein Name
Spindle and kinetochore-associated protein 1
Protein Family
Spindle and kinetochore-associated protein
UniProt Gene Name
SKA1
UniProt Synonym Gene Names
C18orf24
UniProt Entry Name
SKA1_HUMAN
NCBI Protein Information
spindle and kinetochore-associated protein 1; spindle and KT (kinetochore) associated 1

UniProt Comments for SKA1

SKA1: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. Belongs to the SKA1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: microtubule cytoskeleton; spindle microtubule; outer kinetochore of condensed chromosome; cytosol

Molecular Function: protein binding; microtubule binding

Biological Process: mitosis; cell division; mitotic cell cycle; regulation of microtubule polymerization or depolymerization; chromosome segregation
Show more

Research Articles on SKA1

1. the conserved kinetochore-localized Ska1 complex tracks with depolymerizing microtubule ends and associates with both the microtubule lattice and curved protofilaments

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SKA1 antibody

 Reference Product  PubMed Publications
 SKA2 antibody  >12 publications with SKA1 and SKA2
 SKA3 antibody  >10 publications with SKA1 and SKA3
 NDC80 antibody  >4 publications with SKA1 and NDC80
 AURKB antibody  >1 publications with SKA1 and AURKB
 MIS12 antibody  >1 publications with SKA1 and MIS12
 BUB1 antibody  >1 publications with SKA1 and BUB1
 CENPE antibody  >1 publications with SKA1 and CENPE

Pathways associated with anti-SKA1 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Resolution Of Sister Chromatid Cohesion Pathway antibodies  Resolution Of Sister Chromatid Cohesion Pathway Diagram
 Separation Of Sister Chromatids Pathway antibodies  Separation Of Sister Chromatids Pathway Diagram

Diseases associated with anti-SKA1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >4 publications with SKA1 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with SKA1 and Disease Models, Animal
 Neoplasms Antibodies  >2 publications with SKA1 and Neoplasms
 Renal Insufficiency Antibodies  >1 publications with SKA1 and Renal Insufficiency
 Carcinoma, Squamous Cell Antibodies  >1 publications with SKA1 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >1 publications with SKA1 and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with SKA1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with SKA1 and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with SKA1 and Breast Neoplasms

Organs/Tissues associated with anti-SKA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with SKA1 and Kidney
 Lung Antibodies  >2 publications with SKA1 and Lung
 Brain Antibodies  >2 publications with SKA1 and Brain
 Blood Antibodies  >2 publications with SKA1 and Blood
 Skin Antibodies  >1 publications with SKA1 and Skin
 Liver Antibodies  >1 publications with SKA1 and Liver
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