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ADH1C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS641752

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols,… More details

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Product Overview

Online Datasheet in PDF
Product Name
ADH1C, Polyclonal Antibody
Full Product Name
ADH1C, ID (ADH1C, ADH3, Alcohol dehydrogenase 1C, Alcohol dehydrogenase subunit gamma)
Product Gene Name
anti-ADH1C antibody
Product Synonym Names
Anti -ADH1C, ID (ADH1C, ADH3, Alcohol dehydrogenase 1C, Alcohol dehydrogenase subunit gamma)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
39,868 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (100257649..100273917, complement). Location: 4q23
OMIM
103730
3D Structure
ModBase 3D Structure for P00326
Immunogen
ADH1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-268 amino acids from the Central region of human ADH1C.

Product Categories/Family for anti-ADH1C antibody

Antibodies; Abs to Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-ADH1C antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-ADH1C antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50
Immunofluorescence: 1:10-50

Western Blot (WB) of anti-ADH1C antibody

ADH1C Antibody (Center) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the ADH1C antibody detected the ADH1C protein (arrow).
Rabbit Anti-ADH1C Polyclonal Antibody – Cat# MBS641752

Western Blot (WB) of anti-ADH1C antibody

Western blot analysis of ADH1C (arrow) using rabbit polyclonal ADH1C Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ADH1C gene.
Rabbit Anti-ADH1C Polyclonal Antibody, Western Blot (WB) – Cat# MBS641752

Immunohistochemistry (IHC) of anti-ADH1C antibody

ADH1C Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ADH1C Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-ADH1C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS641752

Immunofluorescence (IF) of anti-ADH1C antibody

Confocal immunofluorescent analysis of ADH1C Antibody (Center) with T47D cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-ADH1C Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS641752

Flow Cytometry (FC/FACS) of anti-ADH1C antibody

ADH1C Antibody (Center) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ADH1C Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS641752

Other Notes

Small volumes of anti-ADH1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADH1C purchase

MBS641752 is an antibody targeting ADH1C. Also known as ADH1C, ID (ADH1C, ADH3, Alcohol dehydrogenase 1C, Alcohol dehydrogenase subunit gamma). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADH1C. It may not necessarily be applicable to this product.

NCBI GI #
4501933
NCBI GeneID
126
NCBI Accession #
NP_000660.1
UniProt Primary Accession #
P00326
UniProt Secondary Accession #
Q4PJ18; Q5WRV0; Q6LBW4; Q6NWV0; Q6NZA7
UniProt Related Accession #
P00326
GenBank Nucleotide #
NM_000669.3
NCBI Official Full Name
alcohol dehydrogenase 1C
NCBI Official Synonym Full Names
alcohol dehydrogenase 1C (class I), gamma polypeptide
NCBI Official Symbol
ADH1C
NCBI Official Synonym Symbols
ADH3
UniProt Protein Name
Alcohol dehydrogenase 1C
UniProt Synonym Protein Names
Alcohol dehydrogenase subunit gamma
Protein Family
Alcohol dehydrogenase
UniProt Gene Name
ADH1C
UniProt Synonym Gene Names
ADH3
UniProt Entry Name
ADH1G_HUMAN
NCBI Protein Information
alcohol dehydrogenase 1C; ADH, gamma subunit; aldehyde reductase; alcohol dehydrogenase subunit gamma; alcohol dehydrogenase 3 (class I), gamma polypeptide

UniProt Comments for ADH1C

ADH1C: class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Mitochondrial; EC 1.1.1.1; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Lipid Metabolism - fatty acid

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytosol

Molecular Function: zinc ion binding; alcohol dehydrogenase activity

Biological Process: xenobiotic metabolic process; ethanol oxidation

Disease: Alcohol Dependence; Parkinson Disease, Late-onset
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Research Articles on ADH1C

1. additional support for the association of SNP rs1614972 in ADH1C with alcohol dependence

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADH1C antibody

 Reference Product  PubMed Publications
 ALDH2 antibody  >61 publications with ADH1C and ALDH2
 CYP2E1 antibody  >23 publications with ADH1C and CYP2E1
 ALDH1A1 antibody  >10 publications with ADH1C and ALDH1A1
 GSTM1 antibody  >6 publications with ADH1C and GSTM1
 GSTP1 antibody  >5 publications with ADH1C and GSTP1
 ALDH3A1 antibody  >5 publications with ADH1C and ALDH3A1
 COMT antibody  >4 publications with ADH1C and COMT
 GSTA2 antibody  >1 publications with ADH1C and GSTA2

Pathways associated with anti-ADH1C antibody

 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Omega Oxidation Pathway antibodies  Fatty Acid Omega Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram

Diseases associated with anti-ADH1C antibody

 Disease Name  Pubmed Publications
 Alcoholism Antibodies  >70 publications with ADH1C and Alcoholism
 Genetic Predisposition to Disease Antibodies  >48 publications with ADH1C and Genetic Predisposition to Disease
 Liver Diseases Antibodies  >19 publications with ADH1C and Liver Diseases
 Heart Diseases Antibodies  >13 publications with ADH1C and Heart Diseases
 Mouth Neoplasms Antibodies  >7 publications with ADH1C and Mouth Neoplasms
 Atherosclerosis Antibodies  >6 publications with ADH1C and Atherosclerosis
 Nervous System Diseases Antibodies  >6 publications with ADH1C and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with ADH1C and Brain Diseases
 Congenital Abnormalities Antibodies  >4 publications with ADH1C and Congenital Abnormalities
 Poisoning Antibodies  >2 publications with ADH1C and Poisoning

Organs/Tissues associated with anti-ADH1C antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >36 publications with ADH1C and Liver
 Heart Antibodies  >13 publications with ADH1C and Heart
 Stomach Antibodies  >12 publications with ADH1C and Stomach
 Brain Antibodies  >7 publications with ADH1C and Brain
 Lung Antibodies  >7 publications with ADH1C and Lung
 Intestine Antibodies  >5 publications with ADH1C and Intestine
 Pharynx Antibodies  >4 publications with ADH1C and Pharynx
 Bone Antibodies  >1 publications with ADH1C and Bone
 Muscle Antibodies  >1 publications with ADH1C and Muscle
 Bladder Antibodies  >1 publications with ADH1C and Bladder
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