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ADIPOR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642638

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid… More details

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Product Overview

Online Datasheet in PDF
Product Name
ADIPOR2, Polyclonal Antibody
Full Product Name
ADIPOR2, ID (ADIPOR2, PAQR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II)
Product Gene Name
anti-ADIPOR2 antibody
Product Synonym Names
Anti -ADIPOR2, ID (ADIPOR2, PAQR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II)
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
This antibody is purified through a protein Acolumn, followed by peptide affinity purification.
Concentration
0.39 mg/mL (lot specific)
Specificity
This ADIPOR2 antibody is generated from rabbits immunized with KLH conjugted synthetic peptide between 45-72 amino acids from the Central region of human ADIPOR2.
Preparation and Storage
Maintain refrigerated at 2°C to 8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Chromosome Location
Chromosome: 12; NC_000012.11 (1800147..1897845). Location: 12p13.31
OMIM
607946
3D Structure
ModBase 3D Structure for Q86V24
Immunogen
KLH conjugated synthetic peptide mapping to a fragment of residues within amino acids 45-72 in the central region of human ADIPOR2, UniProt Accession #Q86V24.
Function
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body at and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity).
Cellular Location
Cell membrane; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles
Tissue Location
Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337)
Antigen Region
45-72
Precautions
ADIPO2 Antibody (center) is for research use only

Product Categories/Family for anti-ADIPOR2 antibody

Antibodies; Abs to Obesity Proteins
Applications Tested/Suitable for anti-ADIPOR2 antibody
Suitable for use in ELISA (EIA), Western Blot (WB), Flow Cytometry (FC), Immunofluorescence (IF)
Application Notes for anti-ADIPOR2 antibody
WB~~1:1000
FC~~1:25
IF~~1:10~50

Western Blot (WB) of anti-ADIPOR2 antibody

Western Blot analysis in Hela cell line lysates (35ug/lane) uusing of MBS642638. ADIPOR2 (arrow) was detected using MBS642638.
Rabbit Anti-ADIPOR2 Polyclonal Antibody – Cat# MBS642638

Western Blot (WB) of anti-ADIPOR2 antibody

All lanes : Anti-ADIPOR2 Antibody (Center) at 1:2000 dilution Lane 1: U-251 MG whole cell lysate
Lane 2: U-2OS whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit
IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-ADIPOR2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS642638

Western Blot(WB) of anti-ADIPOR2 antibody

Anti-ADIPOR2 Antibody (Center) at 1:1000 dilution + Human liver tissue lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000
dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-ADIPOR2 Polyclonal Antibody, Western Blot(WB) – Cat# MBS642638

Western Blot (WB) of anti-ADIPOR2 antibody

Anti-ADIPOR2 Antibody (Center) at 1:1000 dilution + Human skeletal muscle tissue lysate
Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 44 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-ADIPOR2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS642638

Immunofluorescence (IF) of anti-ADIPOR2 antibody

Confocal immunofluorescent analysis of Hela cell using MBS642638 followed by Alexa Fluor489-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-ADIPOR2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS642638

Flow Cytometry (FC) of anti-ADIPOR2 antibody

Flow cytometric analysis of Hela cells (right histogram) using MBS642638 compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ADIPOR2 Polyclonal Antibody, Flow Cytometry (FC) – Cat# MBS642638

Other Notes

Small volumes of anti-ADIPOR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADIPOR2 purchase

MBS642638 is an antibody targeting ADIPOR2. Also known as ADIPOR2, ID (ADIPOR2, PAQR2, Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADIPOR2. It may not necessarily be applicable to this product.

NCBI GI #
38261973
NCBI GeneID
79602
NCBI Accession #
NP_078827.2
UniProt Primary Accession #
Q86V24
UniProt Secondary Accession #
Q53YY5; Q9H737
UniProt Related Accession #
Q86V24
GenBank Nucleotide #
NM_024551.2
NCBI Official Full Name
adiponectin receptor protein 2
NCBI Official Synonym Full Names
adiponectin receptor 2
NCBI Official Symbol
ADIPOR2
NCBI Official Synonym Symbols
PAQR2; ACDCR2
UniProt Protein Name
Adiponectin receptor protein 2
UniProt Synonym Protein Names
Progestin and adipoQ receptor family member II
Protein Family
Adiponectin receptor protein
UniProt Gene Name
ADIPOR2
UniProt Synonym Gene Names
PAQR2
UniProt Entry Name
ADR2_HUMAN
NCBI Protein Information
adiponectin receptor protein 2; progestin and adipoQ receptor family member II

NCBI Summary for ADIPOR2

The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003 [PubMed 12802337]).[supplied by OMIM, Mar 2008]
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UniProt Comments for ADIPOR2

ADIPOR2: Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin. Belongs to the ADIPOR family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: plasma membrane; integral to membrane

Molecular Function: adiponectin binding; identical protein binding; hormone binding; protein heterodimerization activity; receptor activity

Biological Process: positive regulation of glucose import; hormone-mediated signaling; heart development; adiponectin-mediated signaling pathway; fatty acid oxidation; female pregnancy; negative regulation of cell growth; response to nutrient
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Research Articles on ADIPOR2

1. APN, AdipoR1, and AdipoR2 exist in human and mouse retinas and retinal APN and AdipoR1 protein levels are elevated in type 1 diabetes mellitus mice.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADIPOR2 antibody

 Reference Product  PubMed Publications
 ADIPOQ antibody  >85 publications with ADIPOR2 and ADIPOQ
 PPARG antibody  >21 publications with ADIPOR2 and PPARG
 APPL1 antibody  >18 publications with ADIPOR2 and APPL1
 STAT3 antibody  >8 publications with ADIPOR2 and STAT3
 LEP antibody  >5 publications with ADIPOR2 and LEP
 PPARA antibody  >2 publications with ADIPOR2 and PPARA
 STK11 antibody  >1 publications with ADIPOR2 and STK11

Pathways associated with anti-ADIPOR2 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram
 Non-alcoholic Fatty Liver Disease (NAFLD) Pathway antibodies  Non-alcoholic Fatty Liver Disease (NAFLD) Pathway Diagram

Diseases associated with anti-ADIPOR2 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >145 publications with ADIPOR2 and Insulin Resistance
 Fatty Liver Antibodies  >65 publications with ADIPOR2 and Fatty Liver
 Neoplasms Antibodies  >57 publications with ADIPOR2 and Neoplasms
 Inflammation Antibodies  >50 publications with ADIPOR2 and Inflammation
 Liver Diseases Antibodies  >48 publications with ADIPOR2 and Liver Diseases
 Cardiovascular Diseases Antibodies  >36 publications with ADIPOR2 and Cardiovascular Diseases
 Necrosis Antibodies  >36 publications with ADIPOR2 and Necrosis
 Disease Models, Animal Antibodies  >32 publications with ADIPOR2 and Disease Models, Animal
 Atherosclerosis Antibodies  >29 publications with ADIPOR2 and Atherosclerosis
 Hyperglycemia Antibodies  >19 publications with ADIPOR2 and Hyperglycemia

Organs/Tissues associated with anti-ADIPOR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >170 publications with ADIPOR2 and Blood
 Adipose Tissue Antibodies  >148 publications with ADIPOR2 and Adipose Tissue
 Liver Antibodies  >121 publications with ADIPOR2 and Liver
 Muscle Antibodies  >113 publications with ADIPOR2 and Muscle
 Connective Tissue Antibodies  >77 publications with ADIPOR2 and Connective Tissue
 Heart Antibodies  >35 publications with ADIPOR2 and Heart
 Brain Antibodies  >26 publications with ADIPOR2 and Brain
 Ovary Antibodies  >20 publications with ADIPOR2 and Ovary
 Placenta Antibodies  >16 publications with ADIPOR2 and Placenta
 Kidney Antibodies  >15 publications with ADIPOR2 and Kidney
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