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TWSG1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS642956

MBS642956 is an antibody targeting TWSG1. Also known as TWSG1 (Twisted Gastrulation Protein Homolog 1, TSG, PSEC0250). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TWSG1, Monoclonal Antibody
Full Product Name
TWSG1 (Twisted Gastrulation Protein Homolog 1, TSG, PSEC0250)
Product Gene Name
anti-TWSG1 antibody
Product Synonym Names
Anti -TWSG1 (Twisted Gastrulation Protein Homolog 1, TSG, PSEC0250)
Immunogen Sequence
AEELSHHENL VSFLETVNQP HHQNVSVPSN NVHAPYSSDK EHMCTVVYFD DCMSIHQCKI SCESMGASKY RWFHNACCEC IGPECIDYGS KTVKCMNCMF
Clonality
Monoclonal
Isotype
IgG3,k
Clone Number
6E6
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human TWSG1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
25,017 Da
Chromosome Location
Chromosome: 18; NC_000018.9 (9334765..9402424). Location: 18p11.3
OMIM
605049
3D Structure
ModBase 3D Structure for Q9GZX9
Immunogen
Partial recombinant corresponding to aa124-224 from human TWSG1 (NP_065699) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-TWSG1 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-TWSG1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-TWSG1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.1ng/ml

Western Blot (WB) of anti-TWSG1 antibody

Western Blot detection against Immunogen (37.11kD).
Mouse Anti-TWSG1 Monoclonal Antibody – Cat# MBS642956

Western Blot (WB) of anti-TWSG1 antibody

Western Blot analysis of TWSG1 expression in transfected 293T cell line by TWSG1 monoclonal antibody.|Lane 1: TWSG1 transfected lysate (25kD).|Lane 2: Non-transfected lysate.
Mouse Anti-TWSG1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS642956

Testing Data of anti-TWSG1 antibody

Detection limit for recombinant GST tagged TWSG1 is ~0.1ng/ml as a capture antibody.
Mouse Anti-TWSG1 Monoclonal Antibody, Testing Data – Cat# MBS642956

Other Notes

Small volumes of anti-TWSG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TWSG1. It may not necessarily be applicable to this product.

NCBI GI #
10190664
NCBI GeneID
57045
NCBI Accession #
NP_065699.1
UniProt Primary Accession #
Q9GZX9
UniProt Secondary Accession #
Q8NBI7; Q96K46; B2RE08; D3DUH9
UniProt Related Accession #
Q9GZX9
GenBank Nucleotide #
NM_020648.5
NCBI Official Full Name
twisted gastrulation protein homolog 1
NCBI Official Synonym Full Names
twisted gastrulation homolog 1 (Drosophila)
NCBI Official Symbol
TWSG1
NCBI Official Synonym Symbols
TSG
UniProt Protein Name
Twisted gastrulation protein homolog 1
Protein Family
Twisted gastrulation protein
UniProt Gene Name
TWSG1
UniProt Synonym Gene Names
TSG
UniProt Entry Name
TWSG1_HUMAN
NCBI Protein Information
twisted gastrulation protein homolog 1

UniProt Comments for TWSG1

TWSG1: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development. Belongs to the twisted gastrulation protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 18p11.3

Cellular Component: extracellular space

Biological Process: BMP signaling pathway; ossification; camera-type eye development; mesoderm formation; salivary gland morphogenesis; forebrain development; hemopoiesis; negative regulation of osteoblast differentiation; cell differentiation; positive regulation of BMP signaling pathway; negative regulation of BMP signaling pathway
Show more

Research Articles on TWSG1

1. mutations in the twisted gastrulation homolog 1 gene are neither a common direct cause nor a frequent modifying factor for human holoprosencephaly pathologies

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TWSG1 antibody

 Reference Product  PubMed Publications
 BMP4 antibody  >5 publications with TWSG1 and BMP4
 BMP2 antibody  >4 publications with TWSG1 and BMP2
 CHRD antibody  >2 publications with TWSG1 and CHRD
 BMP1 antibody  >1 publications with TWSG1 and BMP1

Diseases associated with anti-TWSG1 antibody

 Disease Name  Pubmed Publications
 Holoprosencephaly Antibodies  >5 publications with TWSG1 and Holoprosencephaly
 Congenital Abnormalities Antibodies  >4 publications with TWSG1 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with TWSG1 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with TWSG1 and Liver Diseases
 Jaw Abnormalities Antibodies  >2 publications with TWSG1 and Jaw Abnormalities
 Carcinoma, Hepatocellular Antibodies  >1 publications with TWSG1 and Carcinoma, Hepatocellular
 Neoplasms Antibodies  >1 publications with TWSG1 and Neoplasms
 Disease Models, Animal Antibodies  >1 publications with TWSG1 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with TWSG1 and Kidney Diseases
 Anemia Antibodies  >1 publications with TWSG1 and Anemia

Organs/Tissues associated with anti-TWSG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >16 publications with TWSG1 and Bone
 Blood Antibodies  >4 publications with TWSG1 and Blood
 Embryonic Tissue Antibodies  >3 publications with TWSG1 and Embryonic Tissue
 Liver Antibodies  >2 publications with TWSG1 and Liver
 Bone Marrow Antibodies  >2 publications with TWSG1 and Bone Marrow
 Mouth Antibodies  >2 publications with TWSG1 and Mouth
 Kidney Antibodies  >2 publications with TWSG1 and Kidney
 Brain Antibodies  >2 publications with TWSG1 and Brain
 Vascular Antibodies  >1 publications with TWSG1 and Vascular
 Mammary Gland Antibodies  >1 publications with TWSG1 and Mammary Gland
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