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AIFM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643472

AIFM2 is significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. The protein has been shown to induce apoptosis. This protein is found to be induced by tumor suppressor protein p53 in colon caner cells. More details

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Product Overview

Online Datasheet in PDF
Product Name
AIFM2, Polyclonal Antibody
Full Product Name
AIFM2, CT (AIFM2, AMID, PRG3, Apoptosis-inducing factor 2, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, Apoptosis-inducing factor-like mitochondrion-associated inducer of death, p53-responsive gene 3 protein)
Product Gene Name
anti-AIFM2 antibody
Product Synonym Names
Anti -AIFM2, CT (AIFM2, AMID, PRG3, Apoptosis-inducing factor 2, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, Apoptosis-inducing factor-like mitochondrion-associated inducer of death, p53-responsive gene 3 protein)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
40,527 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (71872023..71892832, complement). Location: 10q22.1
OMIM
605159
3D Structure
ModBase 3D Structure for Q9BRQ8
Immunogen
AIFM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 326~356 amino acids from the C-terminal region of human AIFM2.

Product Categories/Family for anti-AIFM2 antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-AIFM2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes for anti-AIFM2 antibody
Suitable for use in Western Blot, Immunohistochemistry, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-AIFM2 antibody

Western Blot analysis in mouse liver tissue lysates (35ug/lane) using MBS643472. AIFM2 (arrow) was detected using MBS643472.
Rabbit Anti-AIFM2 Polyclonal Antibody – Cat# MBS643472

Immunohistochemistry (IHC) of anti-AIFM2 antibody

Immunohistochemistry analysis of formalin-fixed and paraffin-embedded human hepatocarcinoma using MBS643472, followed by peroxidase-conjugated to the secondary antibody and DAB staining. This data demonstrates the use of MBS643472 for immunohistochemistry.
Rabbit Anti-AIFM2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS643472

Flow Cytometry (FC/FACS) of anti-AIFM2 antibody

Flow Cytometry analysis of HepG2 cells using MBS643472 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-AIFM2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS643472

Other Notes

Small volumes of anti-AIFM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIFM2 purchase

MBS643472 is an antibody targeting AIFM2. Also known as AIFM2, CT (AIFM2, AMID, PRG3, Apoptosis-inducing factor 2, Apoptosis-inducing factor homologous mitochondrion-associated inducer of death, Apoptosis-inducing factor-like mitochondrion-associated inducer of death, p53-responsive gene 3 protein). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AIFM2. It may not necessarily be applicable to this product.

NCBI GI #
23273801
NCBI GeneID
84883
NCBI Accession #
AAH23601.1
UniProt Primary Accession #
Q9BRQ8
UniProt Secondary Accession #
Q63Z39; B3KXI0
UniProt Related Accession #
Q9BRQ8
NCBI Official Full Name
AIFM2 protein
NCBI Official Synonym Full Names
apoptosis-inducing factor, mitochondrion-associated, 2
NCBI Official Symbol
AIFM2
NCBI Official Synonym Symbols
AMID; PRG3; RP11-367H5.2
UniProt Protein Name
Apoptosis-inducing factor 2
UniProt Synonym Protein Names
Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein
Protein Family
Apoptosis-inducing factor
UniProt Gene Name
AIFM2
UniProt Synonym Gene Names
AMID; PRG3
UniProt Entry Name
AIFM2_HUMAN
NCBI Protein Information
apoptosis-inducing factor 2; p53-responsive gene 3 protein; apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death; apoptosis-inducing factor (AIF)-homologous mitochondrion-associated inducer of death

NCBI Summary for AIFM2

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
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UniProt Comments for AIFM2

AIFM2: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. Belongs to the FAD-dependent oxidoreductase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.-.-.-; Apoptosis; Membrane protein, integral; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: extracellular space; mitochondrial outer membrane; mitochondrion; cytoplasm; integral to membrane; lipid particle; cytosol

Molecular Function: DNA binding; FAD binding; NADH dehydrogenase (ubiquinone) activity; electron-transferring-flavoprotein dehydrogenase activity

Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis
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Research Articles on AIFM2

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AIFM2 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >1 publications with AIFM2 and TP53

Pathways associated with anti-AIFM2 antibody

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram

Diseases associated with anti-AIFM2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with AIFM2 and Neoplasms
 Adenocarcinoma Antibodies  >2 publications with AIFM2 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with AIFM2 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >1 publications with AIFM2 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with AIFM2 and Kidney Diseases
 Neoplasms, Experimental Antibodies  >1 publications with AIFM2 and Neoplasms, Experimental

Organs/Tissues associated with anti-AIFM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with AIFM2 and Embryonic Tissue
 Brain Antibodies  >1 publications with AIFM2 and Brain
 Prostate Antibodies  >1 publications with AIFM2 and Prostate
 Kidney Antibodies  >1 publications with AIFM2 and Kidney
 Lung Antibodies  >1 publications with AIFM2 and Lung
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