Parathyroid Hormone Related Peptide, Aa53-86 (PTHLH) Antibody – Mouse Monoclonal

The parathyroid hormone-like hormone (PTHLH) has been recognized in patients suffering from tumors associated with the common neoplastic syndrome humoral hypercalcemia of malignancy (HHM). The 18kD protein is a 177aa precursor that belongs to the parathyroid hormone family. It contains a 24aa signal sequence followed by a 10aa propeptide aa25-34. The mature chain runs from aa37-177. Of note, residues 108-129 constitute a nuclear localization signal (NLS) providing evidence that the protein not only acts as a secreted factor, but in an intracrine manner as well. A second isoform is missing aa176-177, and a 34aa substitution for aa176-177 produces a third isoform. There is a strong homology displayed between PTHLH and human parathyroid hormone (PTH) among the first 13aa. Studies show that the similarity in this area is 67% at the aa and nucleotide levels. Indeed, eight of the first 13aa of PTHLH and PTH are identical. Human PTHLH and mouse PTHLH share 86aa sequence identity.

Small volumes of anti-PTHLH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS643475 is an antibody targeting PTHLH. Also known as Parathyroid Hormone Related Peptide, aa53-86 (Parathyroid Hormone-related Protein, PTHrP, PTH-rP, Humoral Hypercalcemia of Malignancy, HHM, MGC14611, Osteostatin, Parathyroid Hormone-like Hormone, PTHLH, Parathyroid Hormone-like Protein, Parathyroid Hormo. Reactive in Human. Host: Mouse.