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LRRC8D Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS643528

MBS643528 is an antibody targeting LRRC8D. Also known as LRRC5 (LRRC8D, Leucine-rich Repeat-containing Protein 8D, Leucine-rich Repeat-containing Protein 5, UNQ213/PRO239, FLJ10470, FLJ20403). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LRRC5 (LRRC8D), Monoclonal Antibody
Full Product Name
LRRC5 (LRRC8D, Leucine-rich Repeat-containing Protein 8D, Leucine-rich Repeat-containing Protein 5, UNQ213/PRO239, FLJ10470, FLJ20403)
Product Gene Name
anti-LRRC8D antibody
Product Synonym Names
Anti -LRRC5 (LRRC8D, Leucine-rich Repeat-containing Protein 8D, Leucine-rich Repeat-containing Protein 5, UNQ213/PRO239, FLJ10470, FLJ20403)
Immunogen Sequence
MVSSNFWFKY PKTCSKVEHF VSILGKCFES PWTTKALSET ACEDSEENKQ RITGAQTLPK HVSTSSDEGS PSASTPMINK TGFKFSAEKP VIEVPSMTIL DKKDGEQAKA LFEKVRKFRA HVEDSDLIYK LYVVQTASPF PNQ
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3H1-1C2
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human LRRC5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
98,201 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (90286573..90401991). Location: 1p22.2
OMIM
612890
3D Structure
ModBase 3D Structure for Q7L1W4
Immunogen
Full length recombinant corresponding to aa1-486 from human LRRC5 (AAH09486) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-LRRC8D antibody

Antibodies; Abs to Leucine-rich Proteins
Applications Tested/Suitable for anti-LRRC8D antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-LRRC8D antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-LRRC8D antibody

Western Blot detection against Immunogen (41.84kD).
Mouse Anti-LRRC8D Monoclonal Antibody – Cat# MBS643528

Western Blot (WB) of anti-LRRC8D antibody

Western Blot analysis of LRRC8D expression in transfected 293T cell line by LRRC5 monoclonal antibody.|Lane 1: LRRC8D transfected lysate (16kD).|Lane 2: Non-transfected lysate.
Mouse Anti-LRRC8D Monoclonal Antibody, Western Blot (WB) – Cat# MBS643528

Testing Data of anti-LRRC8D antibody

Detection limit for recombinant GST tagged LRRC8D is ~1ng/ml as a capture antibody.
Mouse Anti-LRRC8D Monoclonal Antibody, Testing Data – Cat# MBS643528

Other Notes

Small volumes of anti-LRRC8D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for LRRC8D. It may not necessarily be applicable to this product.

NCBI GI #
197333706
NCBI GeneID
55144
NCBI Accession #
NP_001127951.1
UniProt Primary Accession #
Q7L1W4
UniProt Secondary Accession #
Q6UWB2; Q9NVW3; D3DT29
UniProt Related Accession #
Q7L1W4
GenBank Nucleotide #
NM_001134479.1
NCBI Official Full Name
leucine-rich repeat-containing protein 8D
NCBI Official Synonym Full Names
leucine rich repeat containing 8 family, member D
NCBI Official Symbol
LRRC8D
NCBI Official Synonym Symbols
LRRC5
UniProt Protein Name
Leucine-rich repeat-containing protein 8D
UniProt Synonym Protein Names
Leucine-rich repeat-containing protein 5
Protein Family
Volume-regulated anion channel
UniProt Gene Name
LRRC8D
UniProt Synonym Gene Names
LRRC5
UniProt Entry Name
LRC8D_HUMAN
NCBI Protein Information
leucine-rich repeat-containing protein 8D; leucine rich repeat containing 5; leucine-rich repeat-containing 5; leucine-rich repeat-containing protein 5

UniProt Comments for LRRC8D

LRRC8D: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore. Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309). Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E), possibly to form a heterohexamer

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: ion transport
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Research Articles on LRRC8D

1. LRRC8D is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-LRRC8D antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with LRRC8D and Blood
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