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CELF3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644115

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA… More details

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Product Overview

Online Datasheet in PDF
Product Name
TNRC4 (CELF3), Polyclonal Antibody
Full Product Name
TNRC4, NT (CELF3, BRUNOL1, CAGH4, ERDA4, TNRC4, CUGBP Elav-like family member 3, Bruno-like protein 1, CAG repeat protein 4, CUG-BP- and ETR-3-like factor 3, ELAV-type RNA-binding protein 1, Expanded repeat domain protein CAG/CTG 4, RNA-binding protein BR
Product Gene Name
anti-CELF3 antibody
Product Synonym Names
Anti -TNRC4, NT (CELF3, BRUNOL1, CAGH4, ERDA4, TNRC4, CUGBP Elav-like family member 3, Bruno-like protein 1, CAG repeat protein 4, CUG-BP- and ETR-3-like factor 3, ELAV-type RNA-binding protein 1, Expanded repeat domain protein CAG/CTG 4, RNA-binding protein BR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
50,548 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (151672534..151689290, complement). Location: 1q21
OMIM
612678
3D Structure
ModBase 3D Structure for Q5SZQ8
Immunogen
TNRC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human TNRC4.

Product Categories/Family for anti-CELF3 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-CELF3 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-CELF3 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-CELF3 antibody

TNRC4 Antibody (N-term) western blot analysis in Jurkat,MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TNRC4 antibody detected the TNRC4 protein (arrow).
Rabbit Anti-CELF3 Polyclonal Antibody – Cat# MBS644115

Flow Cytometry (FC/FACS) of anti-CELF3 antibody

TNRC4 Antibody (N-term) flow cytometric analysis of Jurkat cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CELF3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS644115

Other Notes

Small volumes of anti-CELF3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CELF3 purchase

MBS644115 is an antibody targeting CELF3. Also known as TNRC4, NT (CELF3, BRUNOL1, CAGH4, ERDA4, TNRC4, CUGBP Elav-like family member 3, Bruno-like protein 1, CAG repeat protein 4, CUG-BP- and ETR-3-like factor 3, ELAV-type RNA-binding protein 1, Expanded repeat domain protein CAG/CTG 4, RNA-binding protein BR. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CELF3. It may not necessarily be applicable to this product.

NCBI GI #
219520290
NCBI GeneID
11189
NCBI Accession #
AAI43227.1
UniProt Primary Accession #
Q5SZQ8
UniProt Secondary Accession #
O15414; Q499Y6; Q5SZQ7; Q6NVK0; Q8IZ98; Q9BZC2; Q9HB30; B7ZKK6
UniProt Related Accession #
Q5SZQ8
NCBI Official Full Name
TNRC4 protein
NCBI Official Synonym Full Names
CUGBP, Elav-like family member 3
NCBI Official Symbol
CELF3
NCBI Official Synonym Symbols
CAGH4; ERDA4; TNRC4; BRUNOL1
UniProt Protein Name
CUGBP Elav-like family member 3
UniProt Synonym Protein Names
Bruno-like protein 1; CAG repeat protein 4; CUG-BP- and ETR-3-like factor 3; ELAV-type RNA-binding protein 1; ETR-1; Expanded repeat domain protein CAG/CTG 4; RNA-binding protein BRUNOL-1; Trinucleotide repeat-containing gene 4 protein
Protein Family
CUGBP Elav-like family
UniProt Gene Name
CELF3
UniProt Synonym Gene Names
BRUNOL1; CAGH4; ERDA4; TNRC4; CELF-3; ETR-1
UniProt Entry Name
CELF3_HUMAN
NCBI Protein Information
CUGBP Elav-like family member 3; ETR-1; CELF-3; CAG repeat domain; CAG repeat protein 4; bruno-like protein 1; RNA-binding protein BRUNOL-1; CUG-BP and ETR-3 like factor 3; CUG-BP- and ETR-3-like factor 3; ELAV-type RNA-binding protein 1; expanded repeat domain, CAG/CTG 4; trinucleotide repeat containing 4; expanded repeat domain protein CAG/CTG 4; trinucleotide repeat-containing gene 4 protein

UniProt Comments for CELF3

TNRC4: RNA-binding protein involved in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Belongs to the CELF/BRUNOL family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: cytoplasm; nucleus

Molecular Function: mRNA binding; RNA binding; nucleotide binding

Biological Process: nuclear mRNA splicing, via spliceosome; positive regulation of nuclear mRNA splicing, via spliceosome; sperm motility; RNA splicing; spermatogenesis; regulation of alternative nuclear mRNA splicing, via spliceosome
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Research Articles on CELF3

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CELF3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with CELF3 and Neoplasms
 Nervous System Neoplasms Antibodies  >1 publications with CELF3 and Nervous System Neoplasms

Organs/Tissues associated with anti-CELF3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with CELF3 and Brain
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