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CHRNB4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS644774

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHRNB4, Polyclonal Antibody
Full Product Name
CHRNB4, CT (CHRNB4, Neuronal acetylcholine receptor subunit beta-4)
Product Gene Name
anti-CHRNB4 antibody
Product Synonym Names
Anti -CHRNB4, CT (CHRNB4, Neuronal acetylcholine receptor subunit beta-4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
56,380 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (78916636..78933587, complement). Location: 15q24
OMIM
118509
3D Structure
ModBase 3D Structure for P30926
Immunogen
CHRNB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 422-450 amino acids from the C-terminal region of human CHRNB4.

Product Categories/Family for anti-CHRNB4 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-CHRNB4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-CHRNB4 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Western Blot (WB) of anti-CHRNB4 antibody

CHRNB4 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CHRNB4 antibody detected the CHRNB4 protein (arrow).
Rabbit Anti-CHRNB4 Polyclonal Antibody – Cat# MBS644774

Other Notes

Small volumes of anti-CHRNB4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHRNB4 purchase

MBS644774 is an antibody targeting CHRNB4. Also known as CHRNB4, CT (CHRNB4, Neuronal acetylcholine receptor subunit beta-4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRNB4. It may not necessarily be applicable to this product.

NCBI GI #
133778268
NCBI GeneID
1143
NCBI Accession #
AAH96083.1
UniProt Primary Accession #
P30926
UniProt Secondary Accession #
Q16607; Q4VBA5; Q8WXC8; Q9BQR4; A4FTX5; E9PHE8
UniProt Related Accession #
P30926
NCBI Official Full Name
CHRNB4 protein
NCBI Official Synonym Full Names
cholinergic receptor, nicotinic, beta 4 (neuronal)
NCBI Official Symbol
CHRNB4
UniProt Protein Name
Neuronal acetylcholine receptor subunit beta-4
Protein Family
Neuronal acetylcholine receptor
UniProt Gene Name
CHRNB4
UniProt Entry Name
ACHB4_HUMAN
NCBI Protein Information
neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit; cholinergic receptor, nicotinic, beta polypeptide 4; acetylcholine receptor, nicotinic, beta 4 (neuronal)

UniProt Comments for CHRNB4

nAChRB4: After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta- 4/CHRNB4 sub-subfamily.

Protein type: Channel, cation; Receptor, misc.; Membrane protein, integral; Channel, ligand-gated; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; postsynaptic membrane; integral to plasma membrane; plasma membrane; integral to membrane; cell junction

Molecular Function: acetylcholine receptor activity; nicotinic acetylcholine-activated cation-selective channel activity; ligand-gated ion channel activity

Biological Process: regulation of smooth muscle contraction; regulation of action potential; synaptic transmission; smooth muscle contraction; regulation of neurotransmitter secretion; behavioral response to nicotine; locomotory behavior; ion transport; synaptic transmission involved in micturition; signal transduction; cation transport; synaptic transmission, cholinergic
Show more

Research Articles on CHRNB4

1. epigenetic deregulation of nicotinic acetylcholine receptor subunit (nAChR) genes which in the case of CHRNB4 is strongly associated with genetic lung cancer susceptibility variants and a functional impact on tumorigenic potential

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHRNB4 antibody

 Reference Product  PubMed Publications
 CHRNA5 antibody  >92 publications with CHRNB4 and CHRNA5
 CHRNA3 antibody  >82 publications with CHRNB4 and CHRNA3
 CHRNA4 antibody  >12 publications with CHRNB4 and CHRNA4
 CHRNA6 antibody  >10 publications with CHRNB4 and CHRNA6
 CHRNB3 antibody  >10 publications with CHRNB4 and CHRNB3
 CHRNA7 antibody  >8 publications with CHRNB4 and CHRNA7
 CHRNB2 antibody  >7 publications with CHRNB4 and CHRNB2
 PSMA4 antibody  >4 publications with CHRNB4 and PSMA4
 CHRNA2 antibody  >4 publications with CHRNB4 and CHRNA2

Pathways associated with anti-CHRNB4 antibody

 Products by Pathway  Pathway Diagram
 Acetylcholine Binding And Downstream Events Pathway antibodies  Acetylcholine Binding And Downstream Events Pathway Diagram
 Activation Of Nicotinic Acetylcholine Receptors Pathway antibodies  Activation Of Nicotinic Acetylcholine Receptors Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway antibodies  Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway Diagram
 Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway antibodies  Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway antibodies  Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway Diagram

Diseases associated with anti-CHRNB4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >23 publications with CHRNB4 and Neoplasms
 Lung Neoplasms Antibodies  >21 publications with CHRNB4 and Lung Neoplasms
 Nervous System Diseases Antibodies  >18 publications with CHRNB4 and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with CHRNB4 and Brain Diseases
 Alcoholism Antibodies  >7 publications with CHRNB4 and Alcoholism
 Seizures Antibodies  >5 publications with CHRNB4 and Seizures
 Movement Disorders Antibodies  >2 publications with CHRNB4 and Movement Disorders
 Substance Withdrawal Syndrome Antibodies  >2 publications with CHRNB4 and Substance Withdrawal Syndrome
 Weight Gain Antibodies  >1 publications with CHRNB4 and Weight Gain
 Learning Disorders Antibodies  >1 publications with CHRNB4 and Learning Disorders

Organs/Tissues associated with anti-CHRNB4 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >79 publications with CHRNB4 and Nerve
 Brain Antibodies  >31 publications with CHRNB4 and Brain
 Embryonic Tissue Antibodies  >1 publications with CHRNB4 and Embryonic Tissue
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