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DNAJC10 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645473

This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNAJC10, Monoclonal Antibody
Full Product Name
DNAJC10 (DnaJ Homolog Subfamily C Member 10, ER-resident Protein ERdj5, Macrothioredoxin, MTHr, ERDJ5, UNQ495/PRO1012, DKFZp434J1813, MGC104194)
Product Gene Name
anti-DNAJC10 antibody
Product Synonym Names
Anti -DNAJC10 (DnaJ Homolog Subfamily C Member 10, ER-resident Protein ERdj5, Macrothioredoxin, MTHr, ERDJ5, UNQ495/PRO1012, DKFZp434J1813, MGC104194)
Immunogen Sequence
KNHWVIDFYA PWCGPCQNFA PEFELLARMI KGKVKAGKVD CQAYAQTCQK AGIRAYPTVK FYFYERAKRN FQEEQINTRD AKAIAALISE KLETLRNQGK RNKDEL
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3C4
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human DNAJC10. Species Crossreactivity: mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
91,080 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (183580768..183644752). Location: 2q32.1
OMIM
607987
3D Structure
ModBase 3D Structure for Q8IXB1
Immunogen
Partial recombinant corresponding to aa688-794 from human DNAJC10 (NP_061854) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-DNAJC10 antibody

Antibodies; Abs to Heat Shock Proteins
Applications Tested/Suitable for anti-DNAJC10 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-DNAJC10 antibody
Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-DNAJC10 antibody

Western Blot detection against Immunogen (37.77kD).
Mouse Anti-DNAJC10 Monoclonal Antibody – Cat# MBS645473

Western Blot (WB) of anti-DNAJC10 antibody

DNAJC10 monoclonal antibody. Western Blot analysis of DNAJC10 expression in NIH/3T3.
Mouse Anti-DNAJC10 Monoclonal Antibody, Western Blot (WB) – Cat# MBS645473

Immunohistochemistry (IHC) of anti-DNAJC10 antibody

Immunoperoxidase of monoclonal antibody to DNAJC10 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 3ug/ml].
Mouse Anti-DNAJC10 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS645473

Immunofluorescence (IF) of anti-DNAJC10 antibody

Immunofluorescence of monoclonal antibody to DNAJC10 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-DNAJC10 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS645473

Testing Data of anti-DNAJC10 antibody

Detection limit for recombinant GST tagged DNAJC10 is ~10ng/ml as a capture antibody.
Mouse Anti-DNAJC10 Monoclonal Antibody, Testing Data – Cat# MBS645473

Western Blot (WB) of anti-DNAJC10 antibody

DNAJC10 monoclonal antibody. Western Blot analysis of DNAJC10 expression in Raw 264.7.
Mouse Anti-DNAJC10 Monoclonal Antibody, Western Blot (WB) – Cat# MBS645473

Western Blot (WB) of anti-DNAJC10 antibody

DNAJC10 monoclonal antibody. Western Blot analysis of DNAJC10 expression in HeLa.
Mouse Anti-DNAJC10 Monoclonal Antibody, Western Blot (WB) – Cat# MBS645473

Other Notes

Small volumes of anti-DNAJC10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DNAJC10 purchase

MBS645473 is an antibody targeting DNAJC10. Also known as DNAJC10 (DnaJ Homolog Subfamily C Member 10, ER-resident Protein ERdj5, Macrothioredoxin, MTHr, ERDJ5, UNQ495/PRO1012, DKFZp434J1813, MGC104194). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DNAJC10. It may not necessarily be applicable to this product.

NCBI GI #
409971397
NCBI GeneID
54431
NCBI Accession #
NP_001258510.1
UniProt Primary Accession #
Q8IXB1
UniProt Secondary Accession #
Q17RJ6; Q4ZG06; Q53QT7; Q6UWZ6; Q86T61; Q8NC82; Q8TD87; Q96K38; Q96K44; Q96K54; Q9NSY6
UniProt Related Accession #
Q8IXB1
GenBank Nucleotide #
NM_001271581.1
NCBI Official Full Name
dnaJ homolog subfamily C member 10 isoform 2
NCBI Official Synonym Full Names
DnaJ (Hsp40) homolog, subfamily C, member 10
NCBI Official Symbol
DNAJC10
NCBI Official Synonym Symbols
JPDI; MTHr; ERdj5; PDIA19
UniProt Protein Name
DnaJ homolog subfamily C member 10
UniProt Synonym Protein Names
Endoplasmic reticulum DNA J domain-containing protein 5; ER-resident protein ERdj5; ERdj5; Macrothioredoxin
Protein Family
DnaJ homolog subfamily
UniProt Gene Name
DNAJC10
UniProt Synonym Gene Names
ERDJ5; ER-resident protein ERdj5; ERdj5; MTHr
UniProt Entry Name
DJC10_HUMAN
NCBI Protein Information
dnaJ homolog subfamily C member 10; macrothioredoxin; ER-resident protein ERdj5; protein disulfide isomerase family A, member 19; endoplasmic reticulum DNA J domain-containing protein 5; J-domain-containing protein disulfide isomerase-like protein

NCBI Summary for DNAJC10

This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
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UniProt Comments for DNAJC10

DNAJC10: This endoplasmic reticulum co-chaperone may play a role in protein folding and translocation across the endoplasmic reticulum membrane. May act as a co-chaperone for HSPA5. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide; Chaperone

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: membrane; endoplasmic reticulum; endoplasmic reticulum lumen

Molecular Function: disulfide oxidoreductase activity; ATPase activator activity; protein binding; chaperone binding; protein disulfide oxidoreductase activity; Hsp70 protein binding; misfolded protein binding; oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; ATPase binding

Biological Process: ER-associated protein catabolic process; negative regulation of protein amino acid phosphorylation; cell redox homeostasis; positive regulation of ATPase activity
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Research Articles on DNAJC10

1. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DNAJC10 antibody

 Products by Pathway  Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram

Diseases associated with anti-DNAJC10 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with DNAJC10 and Neoplasms
 Adenocarcinoma Antibodies  >1 publications with DNAJC10 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with DNAJC10 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with DNAJC10 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with DNAJC10 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-DNAJC10 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1 publications with DNAJC10 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with DNAJC10 and Embryonic Tissue
 Thymus Antibodies  >1 publications with DNAJC10 and Thymus
 Mouth Antibodies  >1 publications with DNAJC10 and Mouth
 Kidney Antibodies  >1 publications with DNAJC10 and Kidney
 Liver Antibodies  >1 publications with DNAJC10 and Liver
 Brain Antibodies  >1 publications with DNAJC10 and Brain
 Testis Antibodies  >1 publications with DNAJC10 and Testis
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