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CD1A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645708

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CD1A, Polyclonal Antibody
Full Product Name
CD1A, ID (CD1A, T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, CD1a)
Product Gene Name
anti-CD1A antibody
Product Synonym Names
Anti -CD1A, ID (CD1A, T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, CD1a)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
37,077 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (158218119..158228059). Location: 1q22-q23
OMIM
188370
3D Structure
ModBase 3D Structure for P06126
Immunogen
CD1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-104 amino acids from the Central region of human CD1A.

Product Categories/Family for anti-CD1A antibody

Antibodies; Abs to CD Markers
Applications Tested/Suitable for anti-CD1A antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CD1A antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-CD1A antibody

CD1A Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the CD1A antibody detected the CD1A protein (arrow).
Rabbit Anti-CD1A Polyclonal Antibody – Cat# MBS645708

Immunohistochemistry (IHC) of anti-CD1A antibody

CD1A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CD1A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CD1A Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS645708

Other Notes

Small volumes of anti-CD1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD1A purchase

MBS645708 is an antibody targeting CD1A. Also known as CD1A, ID (CD1A, T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, CD1a). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD1A. It may not necessarily be applicable to this product.

NCBI GI #
180036
NCBI GeneID
909
NCBI Accession #
AAA51931.1
UniProt Primary Accession #
P06126
UniProt Secondary Accession #
Q13962; Q5TDJ8; Q9UMM4; Q9Y5M5; D3DVD7
UniProt Related Accession #
P06126
NCBI Official Full Name
CD1a antigen
NCBI Official Synonym Full Names
CD1a molecule
NCBI Official Symbol
CD1A
NCBI Official Synonym Symbols
R4; T6; CD1; FCB6; HTA1
UniProt Protein Name
T-cell surface glycoprotein CD1a
UniProt Synonym Protein Names
T-cell surface antigen T6/Leu-6
Protein Family
T-cell surface glycoprotein
UniProt Gene Name
CD1A
UniProt Synonym Gene Names
hTa1 thymocyte antigen
UniProt Entry Name
CD1A_HUMAN
NCBI Protein Information
T-cell surface glycoprotein CD1a; hTa1 thymocyte antigen; CD1A antigen, a polypeptide; cluster of differentiation 1 A; T-cell surface antigen T6/Leu-6; cortical thymocyte antigen CD1A; differentiation antigen CD1-alpha-3; epidermal dendritic cell marker CD1a

UniProt Comments for CD1A

Function: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Ref.10 Ref.11 Ref.12

Subunit structure: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74. Ref.12

Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note: Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts. Ref.10 Ref.12 Ref.15

Tissue specificity: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. Ref.10 Ref.12

Miscellaneous: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

Sequence similarities: Contains 1 Ig-like (immunoglobulin-like) domain.
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Research Articles on CD1A

1. binding cavity of CD1a is largely preserved in the unliganded state because of persistent electrostatic interactions that keep the portal alpha-helices at a constant separation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD1A antibody

 Reference Product  PubMed Publications
 CD1B antibody  >143 publications with CD1A and CD1B
 CD207 antibody  >90 publications with CD1A and CD207
 CD1E antibody  >28 publications with CD1A and CD1E
 CD9 antibody  >8 publications with CD1A and CD9
 IL1B antibody  >1 publications with CD1A and IL1B

Pathways associated with anti-CD1A antibody

 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with anti-CD1A antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >344 publications with CD1A and Lung Diseases
 Necrosis Antibodies  >315 publications with CD1A and Necrosis
 Inflammation Antibodies  >197 publications with CD1A and Inflammation
 Granuloma Antibodies  >65 publications with CD1A and Granuloma
 Liver Diseases Antibodies  >61 publications with CD1A and Liver Diseases
 Hyperplasia Antibodies  >50 publications with CD1A and Hyperplasia
 Death Antibodies  >49 publications with CD1A and Death
 Breast Neoplasms Antibodies  >44 publications with CD1A and Breast Neoplasms
 Lung Neoplasms Antibodies  >43 publications with CD1A and Lung Neoplasms
 Respiratory Hypersensitivity Antibodies  >33 publications with CD1A and Respiratory Hypersensitivity

Organs/Tissues associated with anti-CD1A antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1459 publications with CD1A and Blood
 Skin Antibodies  >862 publications with CD1A and Skin
 Lymph Node Antibodies  >264 publications with CD1A and Lymph Node
 Lung Antibodies  >151 publications with CD1A and Lung
 Thymus Antibodies  >111 publications with CD1A and Thymus
 Brain Antibodies  >49 publications with CD1A and Brain
 Heart Antibodies  >27 publications with CD1A and Heart
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