Rabbit Anti-POU6F2 Polyclonal Antibody – Cat# MBS645989

POU6F2 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the POU6F2 antibody detected the POU6F2 protein (arrow).

POU6F2 Antibody – Rabbit Polyclonal

Name: POU6F2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS645989
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS645989

This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

POU6F2, Polyclonal Antibody

Full Product Name

POU6F2, NT (POU6F2, RPF1, POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1)

Product Gene Name

anti-POU6F2 antibody

Product Synonym Names

Anti -POU6F2, NT (POU6F2, RPF1, POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

73,265 Da

Chromosome Location

Chromosome: 7; NC_000007.13 (39017609..39504390). Location: 7p14.1

OMIM

601583

3D Structure

ModBase 3D Structure for P78424

Immunogen

POU6F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-61 amino acids from the N-terminal region of human POU6F2.

Product Categories/Family for anti-POU6F2 antibody

Antibodies; Abs to Transcription Factors

Applications Tested/Suitable for anti-POU6F2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-POU6F2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-POU6F2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for POU6F2 purchase

MBS645989 is an antibody targeting POU6F2. Also known as POU6F2, NT (POU6F2, RPF1, POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for POU6F2. It may not necessarily be applicable to this product.

NCBI GI #

260436858

NCBI GeneID

11281

NCBI Accession #

NP_001159490.1

UniProt Primary Accession #

P78424

UniProt Secondary Accession #

P78425; Q75ME8; Q86UM6; Q9UDS7; A4D1W2; C4AMB9

UniProt Related Accession #

P78424

GenBank Nucleotide #

NM_001166018.1

NCBI Official Full Name

POU domain, class 6, transcription factor 2 isoform 2

NCBI Official Synonym Full Names

POU class 6 homeobox 2

NCBI Official Symbol

POU6F2

NCBI Official Synonym Symbols

WT5; WTSL; RPF-1

UniProt Protein Name

POU domain, class 6, transcription factor 2

UniProt Synonym Protein Names

Retina-derived POU domain factor 1

Protein Family

POU domain, class 6, transcription factor

UniProt Gene Name

POU6F2

UniProt Synonym Gene Names

RPF1; RPF-1

UniProt Entry Name

PO6F2_HUMAN

NCBI Protein Information

POU domain, class 6, transcription factor 2; Wilms tumor suppressor locus; retina-derived POU domain factor 1; retina-derived POU-domain factor-1

UniProt Comments for POU6F2

Function: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.

Subcellular location: Nucleus

Probable.

Tissue specificity: Expressed only within the CNS, where its expression is restricted to the medical habenulla, to a dispersed population of neurons in the dorsal hypothalamus, and to subsets of ganglion and amacrine cells in the retina. Ref.1

Involvement in disease: Hereditary susceptibility to Wilms tumor 5 (WT5) [MIM:601583]: Pediatric malignancy of kidney and one of the most common solid cancers in childhood.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4

Sequence similarities: Belongs to the POU transcription factor family. Class-6 subfamily.Contains 1 homeobox DNA-binding domain.Contains 1 POU-specific domain.

Sequence caution: The sequence AAB49727.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAB49728.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAS07475.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence EAL23992.1 differs from that shown. Reason: Erroneous gene model prediction.

Research Articles on POU6F2

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-POU6F2 antibody

Reference Product	PubMed Publications
WT1 antibody	>2 publications with POU6F2 and WT1

Diseases associated with anti-POU6F2 antibody

Disease Name	Pubmed Publications
Wilms Tumor Antibodies	>3 publications with POU6F2 and Wilms Tumor
Autistic Disorder Antibodies	>1 publications with POU6F2 and Autistic Disorder