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LILRA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646235

Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LILRA2, Polyclonal Antibody
Full Product Name
LILRA2, ID (LILRA2, ILT1, LIR7, Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, Leukocyte immunoglobulin-like receptor 7, CD85h)
Product Gene Name
anti-LILRA2 antibody
Product Synonym Names
Anti -LILRA2, ID (LILRA2, ILT1, LIR7, Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, Leukocyte immunoglobulin-like receptor 7, CD85h)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
52,992 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (55084469..55099027). Location: 19q13.4
OMIM
604812
3D Structure
ModBase 3D Structure for Q8N149
Immunogen
LILRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-89 amino acids from the Central region of human LILRA2.

Product Categories/Family for anti-LILRA2 antibody

Antibodies; Abs to CD Markers
Applications Tested/Suitable for anti-LILRA2 antibody
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
Application Notes for anti-LILRA2 antibody
Suitable for use in Western Blot, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Flow Cytometry: 1:10-50

Western Blot (WB) of anti-LILRA2 antibody

LILRA2 Antibody (Center) western blot analysis in NCI-H292,NCI-H460 and A549 cell line lysates (35ug/lane).This demonstrates the LILRA2 antibody detected the LILRA2 protein (arrow).
Rabbit Anti-LILRA2 Polyclonal Antibody – Cat# MBS646235

Flow Cytometry (FC/FACS) of anti-LILRA2 antibody

LILRA2 Antibody (Center) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-LILRA2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS646235

Other Notes

Small volumes of anti-LILRA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LILRA2 purchase

MBS646235 is an antibody targeting LILRA2. Also known as LILRA2, ID (LILRA2, ILT1, LIR7, Leukocyte immunoglobulin-like receptor subfamily A member 2, CD85 antigen-like family member H, Immunoglobulin-like transcript 1, Leukocyte immunoglobulin-like receptor 7, CD85h). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LILRA2. It may not necessarily be applicable to this product.

NCBI GI #
195972797
NCBI GeneID
11027
NCBI Accession #
NP_001124389.1
UniProt Primary Accession #
Q8N149
UniProt Secondary Accession #
O75020
UniProt Related Accession #
Q8N149
GenBank Nucleotide #
NM_001130917.1
NCBI Official Full Name
leukocyte immunoglobulin-like receptor subfamily A member 2 isoform a
NCBI Official Synonym Full Names
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
NCBI Official Symbol
LILRA2
NCBI Official Synonym Symbols
ILT1; LIR7; CD85H; LIR-7
UniProt Protein Name
Leukocyte immunoglobulin-like receptor subfamily A member 2
UniProt Synonym Protein Names
CD85 antigen-like family member H; Immunoglobulin-like transcript 1; ILT-1; Leukocyte immunoglobulin-like receptor 7
Protein Family
Leukocyte immunoglobulin-like receptor subfamily
UniProt Gene Name
LILRA2
UniProt Synonym Gene Names
ILT1; LIR7; ILT-1; LIR-7
UniProt Entry Name
LIRA2_HUMAN
NCBI Protein Information
leukocyte immunoglobulin-like receptor subfamily A member 2; ILT-1; immunoglobulin-like transcript 1; CD85 antigen-like family member H; leukocyte immunoglobulin-like receptor 7; leukocyte immunoglobulin-like receptor subfamily A member 2 soluble

NCBI Summary for LILRA2

This gene encodes a member of the leukocyte Ig-like receptor (LIR) family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The LIR family comprises of activating (subfamily A) and inhibitory (subfamily B) cell-surface receptors. The LIR encoded by this gene was shown to be an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
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UniProt Comments for LILRA2

Function: Does not bind class I MHC antigens. Ref.3

Subunit structure: Homodimer. Ref.3

Subcellular location: Membrane; Single-pass type I membrane protein.

Tissue specificity: Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells. Ref.1

Sequence similarities: Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
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Research Articles on LILRA2

1. LILRA2-mediated activation of monocytes is significantly different to LPS and that LILRA2 selectively modulates LPS-mediated monocyte activation and FcgammaRI-dependent phagocytosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LILRA2 antibody

 Reference Product  PubMed Publications
 SYK antibody  >1 publications with LILRA2 and SYK

Pathways associated with anti-LILRA2 antibody

 Products by Pathway  Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram

Diseases associated with anti-LILRA2 antibody

 Disease Name  Pubmed Publications
 Arthritis Antibodies  >4 publications with LILRA2 and Arthritis
 Inflammation Antibodies  >4 publications with LILRA2 and Inflammation
 Immune System Diseases Antibodies  >3 publications with LILRA2 and Immune System Diseases
 Arthritis, Rheumatoid Antibodies  >3 publications with LILRA2 and Arthritis, Rheumatoid
 Neoplasms Antibodies  >1 publications with LILRA2 and Neoplasms

Organs/Tissues associated with anti-LILRA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with LILRA2 and Blood
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