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Amphiregulin (AREG) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6462819

MBS6462819 is an antibody targeting AREG. Also known as Amphiregulin, CT (AREG, Colorectum Cell-derived Growth Factor, AREGB, AR, SDGF, CRDGF, MGC13647) (FITC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Amphiregulin (AREG), Polyclonal Antibody
Full Product Name
Amphiregulin, CT (AREG, Colorectum Cell-derived Growth Factor, AREGB, AR, SDGF, CRDGF, MGC13647) (FITC)
Product Gene Name
anti-AREG antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human AREG.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.
Molecular Weight
27,895 Da
OMIM
104640
3D Structure
ModBase 3D Structure for P15514
Immunogen
Synthetic peptide selected from the C-terminal region of human AREG (KLH).
Conjugate
FITC
Note
Preservative Free

Product Categories/Family for anti-AREG antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-AREG antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-AREG antibody
IHC: 1:10-1:50
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-AREG antibody

AREG Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the AREG antibody detected the AREG protein (arrow).
Rabbit Anti-AREG Polyclonal Antibody – Cat# MBS6462819

Immunohistochemistry (IHC) of anti-AREG antibody

AREG Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AREG Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-AREG Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6462819

Product References and Citations for anti-AREG antibody

1. Shim, J.Y., J. Korean Med. Sci. 23(5), 857-863 (2008). 2. Eckstein, N., J. Biol. Chem. 283(2), 739-750 (2008). 3. Revillion, F., Ann. Oncol. 19(1), 73-80 (2008). 4. Kimura, H., Nature 348(6298), 257-260 (1990).

Other Notes

Small volumes of anti-AREG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AREG. It may not necessarily be applicable to this product.

NCBI GI #
4502199
NCBI GeneID
374
NCBI Accession #
NP_001648
UniProt Primary Accession #
P15514
UniProt Secondary Accession #
Q5U026
UniProt Related Accession #
P15514
GenBank Nucleotide #
NM_001657.3
NCBI Official Full Name
amphiregulin preproprotein
NCBI Official Synonym Full Names
amphiregulin
NCBI Official Symbol
AREG
NCBI Official Synonym Symbols
AR; SDGF; AREGB; CRDGF
UniProt Protein Name
Amphiregulin
UniProt Synonym Protein Names
Colorectum cell-derived growth factor
Protein Family
Amphiregulin
UniProt Gene Name
AREG
UniProt Synonym Gene Names
SDGF; AR; CRDGF
UniProt Entry Name
AREG_HUMAN
NCBI Protein Information
amphiregulin

NCBI Summary for AREG

The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
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UniProt Comments for AREG

AREG: Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts. Belongs to the amphiregulin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular space; cell surface; cytoplasm; integral to membrane; nucleus

Molecular Function: protein binding; growth factor activity; cytokine activity; epidermal growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; response to peptide hormone stimulus; response to cAMP; response to glucocorticoid stimulus; response to estradiol stimulus; glial cell proliferation; G-protein coupled receptor protein signaling pathway; cell proliferation; cell-cell signaling; response to hydrogen peroxide; positive regulation of cell proliferation; negative regulation of osteoblast differentiation; neurite development; positive regulation of DNA replication; positive regulation of phosphorylation
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Research Articles on AREG

1. Results show that AREG expression is up-regulated in gastric tumor and its co-expression with TROP2 protein is associated with TNM stage, tumor size, lymph node metastases, and distant metastases.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AREG antibody

 Reference Product  PubMed Publications
 EGFR antibody  >83 publications with AREG and EGFR
 PTGS2 antibody  >30 publications with AREG and PTGS2
 ERBB2 antibody  >12 publications with AREG and ERBB2
 PGR antibody  >11 publications with AREG and PGR
 ERBB3 antibody  >5 publications with AREG and ERBB3
 ATF3 antibody  >2 publications with AREG and ATF3
 PTHLH antibody  >1 publications with AREG and PTHLH
 AKT1 antibody  >1 publications with AREG and AKT1

Pathways associated with anti-AREG antibody

 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 COPII (Coat Protein 2) Mediated Vesicle Transport Pathway antibodies  COPII (Coat Protein 2) Mediated Vesicle Transport Pathway Diagram
 Cargo Concentration In The ER Pathway antibodies  Cargo Concentration In The ER Pathway Diagram
 Development And Heterogeneity Of The ILC Family Pathway antibodies  Development And Heterogeneity Of The ILC Family Pathway Diagram
 ER To Golgi Anterograde Transport Pathway antibodies  ER To Golgi Anterograde Transport Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Receptor Signaling Network Pathway antibodies  ErbB Receptor Signaling Network Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Follicle Stimulating Hormone (FSH) Signaling Pathway antibodies  Follicle Stimulating Hormone (FSH) Signaling Pathway Diagram

Diseases associated with anti-AREG antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >76 publications with AREG and Neoplasms
 Carcinoma Antibodies  >32 publications with AREG and Carcinoma
 Breast Neoplasms Antibodies  >26 publications with AREG and Breast Neoplasms
 Inflammation Antibodies  >16 publications with AREG and Inflammation
 Necrosis Antibodies  >16 publications with AREG and Necrosis
 Adenocarcinoma Antibodies  >11 publications with AREG and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >11 publications with AREG and Neoplasms, Experimental
 Neoplasm Metastasis Antibodies  >8 publications with AREG and Neoplasm Metastasis
 Liver Diseases Antibodies  >8 publications with AREG and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >8 publications with AREG and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-AREG antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with AREG and Blood
 Lung Antibodies  >18 publications with AREG and Lung
 Mammary Gland Antibodies  >17 publications with AREG and Mammary Gland
 Liver Antibodies  >12 publications with AREG and Liver
 Skin Antibodies  >11 publications with AREG and Skin
 Vascular Antibodies  >7 publications with AREG and Vascular
 Prostate Antibodies  >7 publications with AREG and Prostate
 Bone Marrow Antibodies  >6 publications with AREG and Bone Marrow
 Intestine Antibodies  >5 publications with AREG and Intestine
 Placenta Antibodies  >4 publications with AREG and Placenta
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