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SEPN1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646366

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SEPN1, Polyclonal Antibody
Full Product Name
SEPN1, CT (SEPN1, SELN, Selenoprotein N)
Product Gene Name
anti-SEPN1 antibody
Product Synonym Names
Anti -SEPN1, CT (SEPN1, SELN, Selenoprotein N)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
65,813 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (26126667..26144713). Location: 1p36.13
OMIM
602771
3D Structure
ModBase 3D Structure for Q9NZV5
Immunogen
SEPN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 416-445 amino acids from the C-terminal region of human SEPN1.

Product Categories/Family for anti-SEPN1 antibody

Antibodies; Abs to Selenoprotein
Applications Tested/Suitable for anti-SEPN1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SEPN1 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Immunohistochemistry (IHC) of anti-SEPN1 antibody

SEPN1 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPN1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-SEPN1 Polyclonal Antibody – Cat# MBS646366

Western Blot (WB) of anti-SEPN1 antibody

SEPN1 Antibody (C-term) western blot analysis in Hela,HepG2 cell line lysates (35ug/lane).This demonstrates the SEPN1 antibody detected the SEPN1 protein (arrow).
Rabbit Anti-SEPN1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS646366

Other Notes

Small volumes of anti-SEPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEPN1 purchase

MBS646366 is an antibody targeting SEPN1. Also known as SEPN1, CT (SEPN1, SELN, Selenoprotein N). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEPN1. It may not necessarily be applicable to this product.

NCBI GI #
47578101
NCBI GeneID
57190
NCBI Accession #
NP_996809.1
UniProt Primary Accession #
Q9NZV5
UniProt Secondary Accession #
Q6PI70; Q969F6; Q9NUI6; A6NJG8; A8MQ64
UniProt Related Accession #
Q9NZV5
GenBank Nucleotide #
NM_206926.1
NCBI Official Full Name
selenoprotein N isoform 2
NCBI Official Synonym Full Names
selenoprotein N, 1
NCBI Official Symbol
SEPN1
NCBI Official Synonym Symbols
RSS; CFTD; SELN; MDRS1; RSMD1
UniProt Protein Name
Selenoprotein N
Protein Family
Selenoprotein
UniProt Gene Name
SEPN1
UniProt Synonym Gene Names
SELN; SelN
UniProt Entry Name
SELN_HUMAN
NCBI Protein Information
selenoprotein N

UniProt Comments for SEPN1

Subcellular location: Isoform 2: Endoplasmic reticulum membrane

Probable. Note: Probably membrane-associated. Ref.5

Tissue specificity: Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach. Ref.1 Ref.5

Domain: The N-terminus (first 61 amino acids) contains an endoplasmic reticulum addressing and retention targeting signal.

Post-translational modification: N-glycosylated (isoform 2).

Involvement in disease: Rigid spine muscular dystrophy 1 (RSMD1) [MIM:602771]: A neuromuscular disorder characterized by poor axial muscle strength, scoliosis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.1 Ref.6 Ref.7 Ref.8

Sequence similarities: Contains 1 EF-hand domain.

Sequence caution: The sequence AAH15638.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH42154.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on SEPN1

1. The physiological function of SelN in muscle tissue and the pathogenesis leading to SEPN1-related myopathies. [Review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEPN1 antibody

 Reference Product  PubMed Publications
 MMD antibody  >11 publications with SEPN1 and MMD
 ACTA1 antibody  >6 publications with SEPN1 and ACTA1
 SELS antibody  >2 publications with SEPN1 and SELS
 MYOT antibody  >2 publications with SEPN1 and MYOT
 SECISBP2 antibody  >2 publications with SEPN1 and SECISBP2
 SEPW1 antibody  >1 publications with SEPN1 and SEPW1

Pathways associated with anti-SEPN1 antibody

 Products by Pathway  Pathway Diagram
 Selenium Metabolism And Selenoproteins Pathway antibodies  Selenium Metabolism And Selenoproteins Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram

Diseases associated with anti-SEPN1 antibody

 Disease Name  Pubmed Publications
 Muscular Dystrophies Antibodies  >21 publications with SEPN1 and Muscular Dystrophies
 Rigid spine syndrome Antibodies  >7 publications with SEPN1 and Rigid spine syndrome
 Atrophy Antibodies  >5 publications with SEPN1 and Atrophy
 Disease Models, Animal Antibodies  >4 publications with SEPN1 and Disease Models, Animal
 Lung Diseases Antibodies  >2 publications with SEPN1 and Lung Diseases
 Hypertrophy Antibodies  >1 publications with SEPN1 and Hypertrophy
 Cataract Antibodies  >1 publications with SEPN1 and Cataract
 Cardiovascular Diseases Antibodies  >1 publications with SEPN1 and Cardiovascular Diseases
 Liver Diseases Antibodies  >1 publications with SEPN1 and Liver Diseases

Organs/Tissues associated with anti-SEPN1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >65 publications with SEPN1 and Muscle
 Embryonic Tissue Antibodies  >6 publications with SEPN1 and Embryonic Tissue
 Connective Tissue Antibodies  >4 publications with SEPN1 and Connective Tissue
 Skin Antibodies  >4 publications with SEPN1 and Skin
 Brain Antibodies  >3 publications with SEPN1 and Brain
 Eye Antibodies  >2 publications with SEPN1 and Eye
 Bone Antibodies  >2 publications with SEPN1 and Bone
 Testis Antibodies  >2 publications with SEPN1 and Testis
 Liver Antibodies  >2 publications with SEPN1 and Liver
 Lung Antibodies  >2 publications with SEPN1 and Lung
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