HOOK3 Antibody – Mouse Polyclonal

Function: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking

By similarity. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Ref.1 Ref.6 Ref.7

Subunit structure: Interacts with Salmonella typhimurium spiC

By similarity. Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with MSR1, and this association is stimulated by ligand binding to MSR1. Interacts with microtubules. Ref.1 Ref.6 Ref.7

Subcellular location: Cytoplasm › cytoskeleton. Golgi apparatus. Note: Enriched at the cis-face of the Golgi complex

By similarity. Localizes to microtubule asters in prophase

By similarity. Ref.1

Sequence similarities: Belongs to the hook family.

Sequence caution: The sequence AAH48304.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.