• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

MMS19 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646721

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19… More details

$880 / 0.05 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MMS19, Polyclonal Antibody
Full Product Name
MMS19 (MMS19 Nucleotide Excision Repair Protein Homolog, hMMS19, MET18 Homolog, MMS19-like Protein, MMS19L, FLJ34167, FLJ95146, MGC99604)
Product Gene Name
anti-MMS19 antibody
Product Synonym Names
Anti -MMS19 (MMS19 Nucleotide Excision Repair Protein Homolog, hMMS19, MET18 Homolog, MMS19-like Protein, MMS19L, FLJ34167, FLJ95146, MGC99604)
Immunogen Sequence
MRELLELSCC HSCPFSSTAA AKCFAGLLNK HPAGQQLDEF LQLAVDKVEA GLGSGPCRSQ AFTLLLWVTK ALVLRYHPLS SCLTARLMGL LSDPELGPAA ADGFSLLMSD CTDVLTRAGH AEVRIMFRQR FFTDNVPALV QGFHAAPPDV KPNYLKGLSH VLNRLPKPVL LPELPTLLSL LLEALSCPDC VVQLSTLSCL QPLLLEAPQV MSLHVDTLVT KFLNLSSSPS MAVRIAALQC MHALTRLPTP VLLPYKPQVI RALAKSLDDK KRLVRKEAVS ARGEWFLLGS PGS
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human MMS19.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
113,290 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (99218081..99258521, complement). Location: 10q24-q25
OMIM
614777
3D Structure
ModBase 3D Structure for Q96T76
Immunogen
Full length human MMS19, aa1-294 (AAH07298).

Product Categories/Family for anti-MMS19 antibody

Antibodies; Abs to DNA Replication; Repair
Applications Tested/Suitable for anti-MMS19 antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-MMS19 antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-MMS19 antibody

Western Blot analysis of MMS19 expression in transfected 293T cell line by MMS19 polyclonal antibody. Lane 1: MMS19L transfected lysate (32.34kD). Lane 2: Non-transfected lysate.
Mouse Anti-MMS19 Polyclonal Antibody – Cat# MBS646721

Immunofluorescence (IF) of anti-MMS19 antibody

Immunofluorescence of purified antibody to MMS19 on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-MMS19 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS646721

Other Notes

Small volumes of anti-MMS19 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MMS19 purchase

MBS646721 is an antibody targeting MMS19. Also known as MMS19 (MMS19 Nucleotide Excision Repair Protein Homolog, hMMS19, MET18 Homolog, MMS19-like Protein, MMS19L, FLJ34167, FLJ95146, MGC99604). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MMS19. It may not necessarily be applicable to this product.

NCBI GI #
170763479
NCBI GeneID
64210
NCBI Accession #
NP_071757.4
UniProt Primary Accession #
Q96T76
UniProt Secondary Accession #
Q17RZ8; Q5T455; Q66K82; Q7L4W8; Q969Z1; B0QZ75; B3KPE5; B4DQX2; B4E2I3; D3DR55; F8W9Y2
UniProt Related Accession #
Q96T76
GenBank Nucleotide #
NM_022362.4
NCBI Official Full Name
MMS19 nucleotide excision repair protein homolog
NCBI Official Synonym Full Names
MMS19 nucleotide excision repair homolog (S. cerevisiae)
NCBI Official Symbol
MMS19
NCBI Official Synonym Symbols
MET18; MMS19L; hMMS19
UniProt Protein Name
MMS19 nucleotide excision repair protein homolog
UniProt Synonym Protein Names
MET18 homolog; MMS19-like protein
Protein Family
DNA repair/transcription protein
UniProt Gene Name
MMS19
UniProt Synonym Gene Names
MMS19L; hMMS19
UniProt Entry Name
MMS19_HUMAN
NCBI Protein Information
MMS19 nucleotide excision repair protein homolog; MET18 homolog; MMS19-like protein; homolog of yeast MMS19; MMS19-like (MET18 homolog, S. cerevisiae)

UniProt Comments for MMS19

Function: Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. Ref.1 Ref.3 Ref.11 Ref.14 Ref.15

Subunit structure: Component of the CIA complex. Component of the MMXD complex, composed of CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Ref.1 Ref.2 Ref.11 Ref.14 Ref.15

Subcellular location: Nucleus. Cytoplasm › cytoskeleton › spindle Ref.1 Ref.2 Ref.3 Ref.11 Ref.15.

Tissue specificity: Ubiquitously expressed with higher expression in testis. Ref.1 Ref.3

Sequence similarities: Belongs to the MET18/MMS19 family.Contains 7 HEAT repeats.

Sequence caution: The sequence AAH80532.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.The sequence BAB55315.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAB71223.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.The sequence BAG51657.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAC29239.1 differs from that shown. Reason: Frameshift at positions 373 and 412.
Show more

Research Articles on MMS19

1. Polymorphisms in ERCC1, codon-118 and MMS19 genes are not associated with clinical response to platinum or survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MMS19 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic Iron-sulfur Cluster Assembly Pathway antibodies  Cytosolic Iron-sulfur Cluster Assembly Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram

Organs/Tissues associated with anti-MMS19 antibody

 Organ/Tissue Name  Pubmed Publications
 Thyroid Antibodies  >1 publications with MMS19 and Thyroid
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000