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CCBP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6467868

MBS6467868 is an antibody targeting CCBP2. Also known as CCBP2, NT (Chemokine-binding Protein 2, Chemokine-binding Protein D6, C-C Chemokine Receptor D6, Chemokine Receptor CCR-9, CCR9, CC-Chemokine Receptor CCR-10, CCR10, CCBP2, CMKBR9) (MaxLight 490).… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCBP2, Polyclonal Antibody
Full Product Name
CCBP2, NT (Chemokine-binding Protein 2, Chemokine-binding Protein D6, C-C Chemokine Receptor D6, Chemokine Receptor CCR-9, CCR9, CC-Chemokine Receptor CCR-10, CCR10, CCBP2, CMKBR9) (MaxLight 490)
Product Gene Name
anti-CCBP2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein G Affinity Chromatography.
Specificity
Recognizes human CCBP2. Species Crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
43kDa
OMIM
602648
3D Structure
ModBase 3D Structure for O00590
Immunogen
Synthetic peptide selected from the N-terminal region of human CCBP2 (KLH).
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-CCBP2 antibody

Antibodies; G Protein Receptors
Applications Tested/Suitable for anti-CCBP2 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-CCBP2 antibody
IHC: 1:50-1:100
FLISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Product References and Citations for anti-CCBP2 antibody

1. Kunkel, E.J., et al., J. Clin. Invest. 111(7):1001-1010 (2003). 2. Fra, A.M., et al., J. Immunol. 170(5):2279-2282 (2003). 3. Soler, D., et al., Blood 101(5):1677-1682 (2003). 4. Nibbs, R.J., et al., Am. J. Pathol. 158(3):867-877 (2001). 5. Bonini, J.A., et al., DNA Cell Biol. 16(10):1249-1256 (1997).

Other Notes

Small volumes of anti-CCBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCBP2. It may not necessarily be applicable to this product.

NCBI GI #
13929467
NCBI GeneID
1238
NCBI Accession #
NP_001287
UniProt Primary Accession #
O00590
UniProt Related Accession #
O00590
GenBank Nucleotide #
NM_001296
NCBI Official Full Name
atypical chemokine receptor 2
NCBI Official Synonym Full Names
atypical chemokine receptor 2
NCBI Official Symbol
ACKR2
NCBI Official Synonym Symbols
D6; hD6; CCR9; CCBP2; CCR10; CMKBR9
UniProt Protein Name
Chemokine-binding protein 2
UniProt Synonym Protein Names
C-C chemokine receptor D6; Chemokine receptor CCR-10; Chemokine receptor CCR-9; Chemokine-binding protein D6
UniProt Gene Name
CCBP2
UniProt Synonym Gene Names
CCR10; CMKBR9
UniProt Entry Name
CCBP2_HUMAN
NCBI Protein Information
atypical chemokine receptor 2

NCBI Summary for CCBP2

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
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UniProt Comments for CCBP2

CCBP2: Receptor for C-C type chemokines including SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: recycling endosome; integral to plasma membrane; early endosome; plasma membrane; actin filament

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; C-C chemokine binding; scavenger receptor activity; C-X-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; neutrophil activation; multicellular organismal development; immune response; chemotaxis; inflammatory response
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Research Articles on CCBP2

1. Data suggest that MIRN146b and MIR10b directly bind 3'-untranslated region of ACKR2 and down-regulate expression of ACKR2 in keratinocytes and in lymphatic endothelial cells, respectively. (ACKR2 = atypical chemokine receptor 2)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCBP2 antibody

 Reference Product  PubMed Publications
 CCL27 antibody  >4 publications with CCBP2 and CCL27
 CCL2 antibody  >3 publications with CCBP2 and CCL2
 CCL3 antibody  >2 publications with CCBP2 and CCL3
 CCL21 antibody  >2 publications with CCBP2 and CCL21
 CCL19 antibody  >2 publications with CCBP2 and CCL19
 CCL5 antibody  >1 publications with CCBP2 and CCL5
 CCL25 antibody  >1 publications with CCBP2 and CCL25

Pathways associated with anti-CCBP2 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-CCBP2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with CCBP2 and Inflammation
 Immune System Diseases Antibodies  >4 publications with CCBP2 and Immune System Diseases
 Fibrosis Antibodies  >1 publications with CCBP2 and Fibrosis
 Hypertrophy Antibodies  >1 publications with CCBP2 and Hypertrophy
 Cardiovascular Diseases Antibodies  >1 publications with CCBP2 and Cardiovascular Diseases
 Necrosis Antibodies  >1 publications with CCBP2 and Necrosis
 Neoplasms Antibodies  >1 publications with CCBP2 and Neoplasms

Organs/Tissues associated with anti-CCBP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >4 publications with CCBP2 and Thymus
 Liver Antibodies  >2 publications with CCBP2 and Liver
 Lung Antibodies  >1 publications with CCBP2 and Lung
 Testis Antibodies  >1 publications with CCBP2 and Testis
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