Goat Anti-CLEC1B Polyclonal Antibody – Cat# MBS646846

(1ug/ml) staining of human kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CLEC1B Antibody – Goat Polyclonal

Name: CLEC1B Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS646846
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646846

Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and… More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CLEC1B, Polyclonal Antibody

Full Product Name

CLEC1B (C-type Lectin Domain Family 1 Member B, C-type Lectin-like Receptor 2, CLEC-2, CLEC2, UNQ721/PRO1384)

Product Gene Name

anti-CLEC1B antibody

Product Synonym Names

Anti -CLEC1B (C-type Lectin Domain Family 1 Member B, C-type Lectin-like Receptor 2, CLEC-2, CLEC2, UNQ721/PRO1384)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human CLEC1B.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

26,596 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (10145660..10153381, complement). Location: 12p13.2

OMIM

606783

3D Structure

ModBase 3D Structure for Q9P126

Immunogen

Synthetic peptide corresponding to KGHKCSPCDTNWRY, from human CLEC1B, at the internal region of the protein (NP_001092901.1, NP_057593.3).

Product Categories/Family for anti-CLEC1B antibody

Antibodies; Abs to Receptors

Applications Tested/Suitable for anti-CLEC1B antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CLEC1B antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1000
Western Blot: 1-3ug/ml, observed in human bone marrow and kidney lysates on ~28kD bands

Other Notes

Small volumes of anti-CLEC1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CLEC1B purchase

MBS646846 is an antibody targeting CLEC1B. Also known as CLEC1B (C-type Lectin Domain Family 1 Member B, C-type Lectin-like Receptor 2, CLEC-2, CLEC2, UNQ721/PRO1384). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for CLEC1B. It may not necessarily be applicable to this product.

NCBI GI #

20810586

NCBI GeneID

51266

NCBI Accession #

AAH29554.1

UniProt Primary Accession #

Q9P126

UniProt Secondary Accession #

Q6UWX7; Q8NHR6

UniProt Related Accession #

Q9P126

NCBI Official Full Name

CLEC1B protein

NCBI Official Synonym Full Names

C-type lectin domain family 1, member B

NCBI Official Symbol

CLEC1B

NCBI Official Synonym Symbols

CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik

UniProt Protein Name

C-type lectin domain family 1 member B

UniProt Synonym Protein Names

C-type lectin-like receptor 2

Protein Family

C-type lectin domain family

UniProt Gene Name

CLEC1B

UniProt Synonym Gene Names

CLEC2; CLEC-2

UniProt Entry Name

CLC1B_HUMAN

NCBI Protein Information

C-type lectin domain family 1 member B; CLEC-2; C-type lectin-like receptor 2; C-type lectin-like receptor-2

NCBI Summary for CLEC1B

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

UniProt Comments for CLEC1B

Function: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. Ref.2 Ref.6

Subunit structure: Homodimer. Interacts (via cytoplasmic domain) with GNB2L1/RACK1; promotes CLEC1B ubiquitination and proteasome-mediated degradation. Interacts (dimer) with SYK (via SH2 domains). Ref.7 Ref.8 Ref.9 Ref.10

Subcellular location: Membrane; Single-pass type II membrane protein

Probable.

Tissue specificity: Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. Ref.1 Ref.2 Ref.6

Post-translational modification: Glycosylated. Ref.6Phosphorylated on tyrosine residue in response to rhodocytin binding. Ref.6

Sequence similarities: Contains 1 C-type lectin domain.

Research Articles on CLEC1B

1. fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CLEC1B antibody

Reference Product	PubMed Publications
PDPN antibody	>1 publications with CLEC1B and PDPN

Diseases associated with anti-CLEC1B antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>1 publications with CLEC1B and Neoplasms