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KCNA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646884

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability,… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
KCNA2, Polyclonal Antibody
Full Product Name
KCNA2, CT (KCNA2, Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv1.2)
Product Gene Name
anti-KCNA2 antibody
Product Synonym Names
Anti -KCNA2, CT (KCNA2, Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv1.2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
56,717 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (111136202..111174096, complement). Location: 1p13
OMIM
176262
3D Structure
ModBase 3D Structure for P16389
Immunogen
KCNA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 450-479 amino acids from the C-terminal region of human KCNA2.

Product Categories/Family for anti-KCNA2 antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-KCNA2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KCNA2 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-KCNA2 antibody

KCNA2 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCNA2 antibody detected the KCNA2 protein (arrow).
Rabbit Anti-KCNA2 Polyclonal Antibody – Cat# MBS646884

Immunohistochemistry (IHC) of anti-KCNA2 antibody

KCNA2 Antibody (C-term) (AP14749b)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KCNA2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-KCNA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS646884

Other Notes

Small volumes of anti-KCNA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNA2 purchase

MBS646884 is an antibody targeting KCNA2. Also known as KCNA2, CT (KCNA2, Potassium voltage-gated channel subfamily A member 2, NGK1, Voltage-gated K(+) channel HuKIV, Voltage-gated potassium channel HBK5, Voltage-gated potassium channel subunit Kv1.2). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KCNA2. It may not necessarily be applicable to this product.

NCBI GI #
28175209
NCBI GeneID
3737
NCBI Accession #
AAH43564.1
UniProt Primary Accession #
P16389
UniProt Secondary Accession #
Q86XG6
UniProt Related Accession #
P16389
NCBI Official Full Name
KCNA2 protein
NCBI Official Synonym Full Names
potassium voltage-gated channel, shaker-related subfamily, member 2
NCBI Official Symbol
KCNA2
NCBI Official Synonym Symbols
HK4; MK2; HBK5; NGK1; RBK2; HUKIV; KV1.2
UniProt Protein Name
Potassium voltage-gated channel subfamily A member 2
UniProt Synonym Protein Names
NGK1; Voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; Voltage-gated potassium channel subunit Kv1.2
Protein Family
Potassium voltage-gated channel subfamily
UniProt Gene Name
KCNA2
UniProt Entry Name
KCNA2_HUMAN
NCBI Protein Information
potassium voltage-gated channel subfamily A member 2; voltage-gated K(+) channel HuKIV; voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; voltage-gated potassium channel subunit Kv1.2

UniProt Comments for KCNA2

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Subunit structure: Heterotetramer of potassium channel proteins. Binds PDZ domains of DLG1, DLG2 and DLG4

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Post-translational modification: Phosphorylated on tyrosine residues by activated PTK2B/PYK2; this regulates ion channel activity

By similarity.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily. [View classification]
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Research Articles on KCNA2

1. This study indicated that the T2DM condition leads to potassium channel-mediated peripheral nerve hyperexcitability , thus identifying them as a potential drug target to treat some of the DPN related symptoms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KCNA2 antibody

 Reference Product  PubMed Publications
 KCNA1 antibody  >36 publications with KCNA2 and KCNA1
 KCNA5 antibody  >26 publications with KCNA2 and KCNA5
 KCNA4 antibody  >22 publications with KCNA2 and KCNA4
 KCNA3 antibody  >20 publications with KCNA2 and KCNA3
 KCNAB2 antibody  >4 publications with KCNA2 and KCNAB2
 KCNAB1 antibody  >3 publications with KCNA2 and KCNAB1
 CTTN antibody  >1 publications with KCNA2 and CTTN
 KCNH2 antibody  >1 publications with KCNA2 and KCNH2

Pathways associated with anti-KCNA2 antibody

 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with anti-KCNA2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >19 publications with KCNA2 and Nervous System Diseases
 Brain Diseases Antibodies  >10 publications with KCNA2 and Brain Diseases
 Disease Models, Animal Antibodies  >4 publications with KCNA2 and Disease Models, Animal
 Congenital Abnormalities Antibodies  >3 publications with KCNA2 and Congenital Abnormalities
 Heart Diseases Antibodies  >3 publications with KCNA2 and Heart Diseases
 Edema Antibodies  >2 publications with KCNA2 and Edema
 Nervous System Malformations Antibodies  >2 publications with KCNA2 and Nervous System Malformations
 Nerve Degeneration Antibodies  >2 publications with KCNA2 and Nerve Degeneration
 Heart Defects, Congenital Antibodies  >1 publications with KCNA2 and Heart Defects, Congenital
 Coma Antibodies  >1 publications with KCNA2 and Coma

Organs/Tissues associated with anti-KCNA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with KCNA2 and Brain
 Blood Antibodies  >6 publications with KCNA2 and Blood
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