• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

GGA1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS646949

GGA1 is a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These… More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GGA1, Polyclonal Antibody
Full Product Name
GGA1, NT (GGA1, ADP-ribosylation factor-binding protein GGA1, Gamma-adaptin-related protein 1, Golgi-localized, gamma ear-containing, ARF-binding protein 1)
Product Gene Name
anti-GGA1 antibody
Product Synonym Names
Anti -GGA1, NT (GGA1, ADP-ribosylation factor-binding protein GGA1, Gamma-adaptin-related protein 1, Golgi-localized, gamma ear-containing, ARF-binding protein 1)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
72,277 Da
Chromosome Location
Chromosome: 22; NC_000022.10 (38004481..38029571). Location: 22q13.31
3D Structure
ModBase 3D Structure for Q6IC75
Immunogen
GGA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1~30 amino acids from the N-terminal region of human GGA1.

Product Categories/Family for anti-GGA1 antibody

Antibodies; Abs to GTPase; Rab; Ras; Rho Proteins
Applications Tested/Suitable for anti-GGA1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-GGA1 antibody
Suitable for use in Western Blot, Immunofluorescence, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunofluorescence

Western Blot (WB) of anti-GGA1 antibody

The anti-GGA1 Pab is used in Western blot to detect GGA1 in mouse kidney tissue lysate (lane 1) and Jurkat cell lysate (lane 2).
Rabbit Anti-GGA1 Polyclonal Antibody – Cat# MBS646949

Testing Data of anti-GGA1 antibody

A, N2a cells cotransfected with APP770 –V5 and GGA1 –myc or empty vector were immunostained for APP (Alexa488; green), GGA1 (Cy5; blue), and the Golgi marker GM130 (Cy3; red). B, The same transfection was stained for the endosomal marker EEA1 (Cy3). C, To assess cell-surface localization, APP695 –GFP and GGA1 –myc or empty vector were cotransfected and then immunostained with an Ab to the APP ectodomain on ice without permeabilization (Cy3). Cells were then fixed, permeabilized, and stained for GGA1 (Cy5). (J. Neurosci. 2006 Sep 27;26(39):9913-9922)
Rabbit Anti-GGA1 Polyclonal Antibody, Testing Data – Cat# MBS646949

Other Notes

Small volumes of anti-GGA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GGA1 purchase

MBS646949 is an antibody targeting GGA1. Also known as GGA1, NT (GGA1, ADP-ribosylation factor-binding protein GGA1, Gamma-adaptin-related protein 1, Golgi-localized, gamma ear-containing, ARF-binding protein 1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GGA1. It may not necessarily be applicable to this product.

NCBI GI #
47678517
NCBI GeneID
26088
NCBI Accession #
CAG30379.1
UniProt Primary Accession #
Q6IC75
UniProt Secondary Accession #
Q5R3N1
UniProt Related Accession #
Q9UJY5
NCBI Official Full Name
GGA1
NCBI Official Synonym Full Names
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
NCBI Official Symbol
GGA1
UniProt Protein Name
ADP-ribosylation factor-binding protein GGA1
Protein Family
ADP-ribosylation factor-binding protein
UniProt Gene Name
GGA1
UniProt Entry Name
Q6IC75_HUMAN
NCBI Protein Information
ADP-ribosylation factor-binding protein GGA1; gamma-adaptin related protein 1; gamma-adaptin-related protein 1; ADP-ribosylation factor binding protein 1; golgi-localized, gamma ear-containing, ARF-binding protein 1; golgi associated, gamma adaptin ear containing, ARF binding protein 1

NCBI Summary for GGA1

This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for GGA1

Sequence similarities: Contains VHS domain. SAAS SAAS002014

Research Articles on GGA1

1. On basis of these results, propose that GGA1 facilitates LR11 endocytic traffic and that LR11 modulates A-beta levels by promoting amyloid-beta precursor protein traffic to the endocytic recycling compartment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GGA1 antibody

 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram

Organs/Tissues associated with anti-GGA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with GGA1 and Brain
 Muscle Antibodies  >6 publications with GGA1 and Muscle
 Blood Antibodies  >5 publications with GGA1 and Blood
 Kidney Antibodies  >4 publications with GGA1 and Kidney
 Nerve Antibodies  >4 publications with GGA1 and Nerve
 Bone Antibodies  >2 publications with GGA1 and Bone
 Connective Tissue Antibodies  >2 publications with GGA1 and Connective Tissue
 Heart Antibodies  >2 publications with GGA1 and Heart
 Lung Antibodies  >2 publications with GGA1 and Lung
 Intestine Antibodies  >2 publications with GGA1 and Intestine
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000