SFRP4 Antibody – Rabbit Polyclonal

Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling

By similarity. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Ref.2

Subcellular location: Secreted. Note: Cytoplasmic in ovarian tumor cells. Ref.10

Tissue specificity: Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level). Ref.9 Ref.10

Induction: Increased levels in failing myocardium. Up-regulated in several tumor types including ostomalacia-associated tumors and endometrial and breast carcinomas.

Domain: The FZ domain is involved in binding with Wnt ligands

By similarity.

Sequence similarities: Belongs to the secreted frizzled-related protein (sFRP) family.Contains 1 FZ (frizzled) domain.Contains 1 NTR domain.

Sequence caution: The sequence BAG63683.1 differs from that shown. Reason: Erroneous initiation.