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DNM3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6473279

MBS6473279 is an antibody targeting DNM3. Also known as DNM3, ID (T-dynamin, Dynamin, Testicular, Dynamin-3, KIAA0820) (FITC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
DNM3, Polyclonal Antibody
Full Product Name
DNM3, ID (T-dynamin, Dynamin, Testicular, Dynamin-3, KIAA0820) (FITC)
Product Gene Name
anti-DNM3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human DNM3.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
62,824 Da
OMIM
611445
3D Structure
ModBase 3D Structure for Q9UQ16
Immunogen
Synthetic peptide selected from the center region of human DNM3 (KLH).
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-DNM3 antibody

Antibodies; Neuroscience
Applications Tested/Suitable for anti-DNM3 antibody
Western Blot (WB), FLISA
Application Notes for anti-DNM3 antibody
WB: 1:100-1:500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-DNM3 antibody

Western blot analysis of DNM3 Antibody (Center) in HL-60 cell line lysates (35ug/lane). DNM3 (arrow) was detected using the purified Pab.
Rabbit Anti-DNM3 Polyclonal Antibody – Cat# MBS6473279

Immunohistochemistry (IHC) of anti-DNM3 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with DNM3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-DNM3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6473279

Flow Cytometry (FC/FACS) of anti-DNM3 antibody

DNM3 Antibody (Center) flow cytometry analysis of NCI-H292 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-DNM3 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6473279

Product References and Citations for anti-DNM3 antibody

1. Orth, J.D. et.al., Curr. Opin. Cell Biol. 15(1), 31-39 (2003).

Other Notes

Small volumes of anti-DNM3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DNM3. It may not necessarily be applicable to this product.

NCBI GI #
42544243
NCBI GeneID
26052
NCBI Accession #
NP_056384.2
UniProt Primary Accession #
Q9UQ16
UniProt Secondary Accession #
O14982; O95555; Q1MTM8; Q5W129; Q6P2G1; Q9H0P3; Q9H548; Q9NQ68; Q9NQN6; A9Z1Y1
UniProt Related Accession #
Q9UQ16
GenBank Nucleotide #
NM_015569.4
NCBI Official Full Name
dynamin-3 isoform a
NCBI Official Synonym Full Names
dynamin 3
NCBI Official Symbol
DNM3
NCBI Official Synonym Symbols
Dyna III
UniProt Protein Name
Dynamin-3
UniProt Synonym Protein Names
Dynamin, testicular; T-dynamin
Protein Family
Dynamin
UniProt Gene Name
DNM3
UniProt Synonym Gene Names
KIAA0820
UniProt Entry Name
DYN3_HUMAN
NCBI Protein Information
dynamin-3

NCBI Summary for DNM3

This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
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UniProt Comments for DNM3

DYN3: a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Concentrates within dendritic spine tips of the postsynaptic compartment and interacts with mGluR5 and Homer. May play a role in dendritic spine morphogenesis and remodeling.

Protein type: Mitochondrial; Vesicle; Microtubule-binding; Hydrolase; Motility/polarity/chemotaxis; EC 3.6.5.5; Motor

Chromosomal Location of Human Ortholog: 1q24.3

Cellular Component: microtubule; mitochondrion; perinuclear region of cytoplasm; postsynaptic density; dendritic spine

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: filopodium formation; synaptogenesis; metabolic process; endocytosis
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Research Articles on DNM3

1. Data show that the classical dynamin DNM1 and DNM3 genes reach their maximum expression levels (100% of maximal expression) in all normal central nervous system tissues studied.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DNM3 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram

Diseases associated with anti-DNM3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with DNM3 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with DNM3 and Brain Diseases
 Abnormalities, Multiple Antibodies  >2 publications with DNM3 and Abnormalities, Multiple
 Lung Neoplasms Antibodies  >1 publications with DNM3 and Lung Neoplasms
 Proteinuria Antibodies  >1 publications with DNM3 and Proteinuria
 Lung Diseases Antibodies  >1 publications with DNM3 and Lung Diseases
 Kidney Diseases Antibodies  >1 publications with DNM3 and Kidney Diseases
 Inflammation Antibodies  >1 publications with DNM3 and Inflammation

Organs/Tissues associated with anti-DNM3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with DNM3 and Blood
 Brain Antibodies  >6 publications with DNM3 and Brain
 Connective Tissue Antibodies  >3 publications with DNM3 and Connective Tissue
 Lung Antibodies  >2 publications with DNM3 and Lung
 Muscle Antibodies  >2 publications with DNM3 and Muscle
 Kidney Antibodies  >2 publications with DNM3 and Kidney
 Embryonic Tissue Antibodies  >2 publications with DNM3 and Embryonic Tissue
 Uterus Antibodies  >1 publications with DNM3 and Uterus
 Ear Antibodies  >1 publications with DNM3 and Ear
 Placenta Antibodies  >1 publications with DNM3 and Placenta
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