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CYP2C18 Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647338

CYP2C18 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CYP2C18, Polyclonal Antibody
Full Product Name
CYP2C18 (Cytochrome P450 2C18, CYPIIC18, Cytochrome P450-6B/29C)
Product Gene Name
Product Synonym Names
Anti -CYP2C18 (Cytochrome P450 2C18, CYPIIC18, Cytochrome P450-6B/29C)
Immunogen Sequence
MDPAVALVLC LSCLFLLSLW RQSSGRGRLP SGPTPLPIIG NILQLDVKDM SKSLTNFSKV YGPVFTVYFG LKPIVVLHGY EAVKEALIDH GEEFSGRGSF PVAEKVNKGL GILFSNGKRW KEIRRFCLMT LRNFGMGKRS IEDRVQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS VIFHDRFDYK DQRFLNLMEK FNENLRILSS PWIQVCNNFP ALIDYLPGSH NKIAENFAYI KSYVLERIKE HQESLDMNSA RDFIDCFLIK MEQEKHNQQS EFTVESLIAT VTDMFGAGTE TTSTTLRYGL LLLLKYPEVT AKVQEEIECV VGRNRSPCMQ DRSHMPYTDA VVHEIQRYID LLPTNLPHAV TCDVKFKNYL IPKGTTIITS LTSVLHNDKE FPNPEMFDPG HFLDKSGNFK KSDYFMPFSA GKRMCMGEGL ARMELFLFLT TILQNFNLKS QVDPKDIDIT PIANAFGRVP PLYQLCFIPV
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human CYP2C18.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,711 Da
Chromosome Location
Chromosome: 10; NC_000010.10 (96443251..96495947). Location: 10q24
OMIM
601131
3D Structure
ModBase 3D Structure for P33260
Immunogen
Full length human CYP2C18, aa1-490 (NP_000763.1).

Product Categories/Family for anti-CYP2C18 antibody

Applications Tested/Suitable for anti-CYP2C18 antibody
Western Blot (WB)
Application Notes for anti-CYP2C18 antibody
Suitable for use in Western Blot.

Western Blot (WB) of anti-CYP2C18 antibody

Western Blot analysis of CYP2C18 expression in transfected 293T cell line by CYP2C18 polyclonal antibody. Lane1:CYP2C18 transfected lysate (53.9kD). Lane2:Non-transfected lysate.
Mouse Anti-CYP2C18 Polyclonal Antibody – Cat# MBS647338

Other Notes

Small volumes of anti-CYP2C18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CYP2C18 purchase

MBS647338 is an antibody targeting CYP2C18. Also known as CYP2C18 (Cytochrome P450 2C18, CYPIIC18, Cytochrome P450-6B/29C). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CYP2C18. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cytochrome P450 2C18 isoform 2
NCBI Official Synonym Full Names
cytochrome P450, family 2, subfamily C, polypeptide 18
NCBI Official Symbol
CYP2C18
NCBI Official Synonym Symbols
CPCI; CYP2C; CYP2C17; P450IIC17; P450-6B/29C
UniProt Protein Name
Cytochrome P450 2C18
UniProt Synonym Protein Names
CYPIIC18; Cytochrome P450-6b/29c
Protein Family
UniProt Gene Name
CYP2C18
UniProt Entry Name
CP2CI_HUMAN
NCBI Protein Information
cytochrome P450 2C18; CYPIIC18; cytochrome P450-6B/29C; microsomal monooxygenase; unspecific monooxygenase; flavoprotein-linked monooxygenase; (S)-mephenytoin hydroxylase associated cytochrome P450; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 17; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 18

NCBI Summary for CYP2C18

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CYP2C18

Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor: Heme group

By similarity.

Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Sequence similarities: Belongs to the cytochrome P450 family.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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