Rabbit Anti-CENPC Polyclonal Antibody – Cat# MBS647485

CENPC1 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPC1 antibody detected the CENPC1 protein (arrow).

CENPC1 (CENPC) Antibody – Rabbit Polyclonal

Name: CENPC Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647485
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647485

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CENPC1, Polyclonal Antibody

Full Product Name

CENPC1, ID (CENPC1, CENPC, ICEN7, Centromere protein C 1, Centromere autoantigen C, Interphase centromere complex protein 7)

Product Gene Name

anti-CENPC antibody

Product Synonym Names

Anti -CENPC1, ID (CENPC1, CENPC, ICEN7, Centromere protein C 1, Centromere autoantigen C, Interphase centromere complex protein 7)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

106,834 Da

Chromosome Location

Chromosome: 4; NC_000004.11 (68337989..68411256, complement). Location: 4q13.2

OMIM

117141

3D Structure

ModBase 3D Structure for Q03188

Immunogen

CENPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-424 amino acids from the Central region of human CENPC1.

Product Categories/Family for anti-CENPC antibody

Antibodies; Abs to Centromeres

Applications Tested/Suitable for anti-CENPC antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CENPC antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-CENPC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CENPC purchase

MBS647485 is an antibody targeting CENPC. Also known as CENPC1, ID (CENPC1, CENPC, ICEN7, Centromere protein C 1, Centromere autoantigen C, Interphase centromere complex protein 7). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CENPC. It may not necessarily be applicable to this product.

NCBI GI #

68508961

NCBI GeneID

1060

NCBI Accession #

NP_001803.2

UniProt Primary Accession #

Q03188

UniProt Secondary Accession #

Q9P0M5

UniProt Related Accession #

Q03188

GenBank Nucleotide #

NM_001812.2

NCBI Official Full Name

centromere protein C

NCBI Official Synonym Full Names

centromere protein C

NCBI Official Symbol

CENPC

NCBI Official Synonym Symbols

MIF2; hcp-4; CENP-C; CENPC1

UniProt Protein Name

Centromere protein C

UniProt Synonym Protein Names

Centromere autoantigen C; Centromere protein C 1; CENP-C 1; Interphase centromere complex protein 7

Protein Family

Centromere protein

UniProt Gene Name

CENPC

UniProt Synonym Gene Names

CENPC1; ICEN7; CENP-C; CENP-C 1

UniProt Entry Name

CENPC_HUMAN

NCBI Protein Information

centromere protein C; CENP-C 1; centromere protein C 1; centromere autoantigen C; centromere autoantigen C1; interphase centromere complex protein 7

NCBI Summary for CENPC

UniProt Comments for CENPC

Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. Ref.10 Ref.13

Subunit structure: Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA. Ref.6 Ref.9 Ref.10

Subcellular location: Nucleus. Chromosome › centromere › kinetochore. Note: Localizes exclusively in the kinetochore domain of centromeres. Ref.7 Ref.10 Ref.13

Domain: The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization. Ref.9

Sequence similarities: Belongs to the CENPC family.

Research Articles on CENPC

1. CENP-C works as an important factor for centromeric M18BP1 recruitment

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CENPC antibody

Reference Product	PubMed Publications
CENPA antibody	>7 publications with CENPC and CENPA
CENPE antibody	>2 publications with CENPC and CENPE
CENPH antibody	>1 publications with CENPC and CENPH

Pathways associated with anti-CENPC antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
M Phase Pathway antibodies	M Phase Pathway Diagram
Mitotic Anaphase Pathway antibodies	Mitotic Anaphase Pathway Diagram
Mitotic Metaphase And Anaphase Pathway antibodies	Mitotic Metaphase And Anaphase Pathway Diagram
Mitotic Prometaphase Pathway antibodies	Mitotic Prometaphase Pathway Diagram
Resolution Of Sister Chromatid Cohesion Pathway antibodies	Resolution Of Sister Chromatid Cohesion Pathway Diagram
Separation Of Sister Chromatids Pathway antibodies	Separation Of Sister Chromatids Pathway Diagram

Diseases associated with anti-CENPC antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with CENPC and Neoplasms
Leukemia Antibodies	>1 publications with CENPC and Leukemia

Organs/Tissues associated with anti-CENPC antibody

Organ/Tissue Name	Pubmed Publications
Connective Tissue Antibodies	>1 publications with CENPC and Connective Tissue
Lung Antibodies	>1 publications with CENPC and Lung
Liver Antibodies	>1 publications with CENPC and Liver
Embryonic Tissue Antibodies	>1 publications with CENPC and Embryonic Tissue
Kidney Antibodies	>1 publications with CENPC and Kidney
Eye Antibodies	>1 publications with CENPC and Eye