PSMB11 Antibody – Rabbit Polyclonal

Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T-cells. Ref.1

Catalytic activity: Cleavage of peptide bonds with very broad specificity.

Subunit structure: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Incorporated instead of PSMB5 and PSMB8. Ref.1

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity.

Tissue specificity: Expressed exclusively in cortical thymic epithelial cells. Ref.1

Disruption phenotype: Displays defective development of CD8-positive T-cells in the thymus. Ref.1

Sequence similarities: Belongs to the peptidase T1B family.