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CRP Native Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS537672

MBS537672 is a native protein targeting CRP. Also known as CRP protein. Host: Human. Purified native Human CRP protein More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CRP, Native Protein
Full Product Name
CRP protein
Product Gene Name
CRP native protein
Product Synonym Names
C-Reactive Protein; CRP antigen
Host
Human
Form/Format
0.1M Tris buffer, pH 7.5, with 0.1% NaN3 and 0.2M NaCl.
Purity/Purification
Highly pure
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
10,415 Da
OMIM
123260
3D Structure
ModBase 3D Structure for P02741
Source Note
Human fluids
Protein Type
Native
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

Product Categories/Family for CRP native protein

Cardiac Markers; Native Protein
Applications Tested/Suitable for CRP native protein
Control
Application Notes for CRP native protein
This highly purified product is usually used as an immunogen or for labeling and is suitable for single or multianalyte controls.

Product References and Citations for CRP native protein

Extraction of C-reactive protein from serum on a microfluidic chip; Michael G. Ropera, Megan L. Friska, Janeen P. Oberlandera, Jerome P. Ferrancea, Brian J. McGroryb, James P. Landers (Analytica Chimica Acta: Volume: 569 Issue: 1-2 Page: 195-202 DOI: 10.1016/j.aca.2006.03.096)

Other Notes

Small volumes of CRP native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CRP. It may not necessarily be applicable to this product.

NCBI GI #
30224
NCBI GeneID
1401
NCBI Accession #
CAA39671.1
UniProt Primary Accession #
P02741
UniProt Secondary Accession #
Q08AK3; Q8WW75; A8K078; D3DVD9; D3DVE0
UniProt Related Accession #
P02741
NCBI Official Full Name
C-reactive protein
NCBI Official Synonym Full Names
C-reactive protein, pentraxin-related
NCBI Official Symbol
CRP
NCBI Official Synonym Symbols
PTX1
UniProt Protein Name
C-reactive protein
Protein Family
C-reactive protein
UniProt Gene Name
CRP
UniProt Synonym Gene Names
PTX1
UniProt Entry Name
CRP_HUMAN
NCBI Protein Information
C-reactive protein

NCBI Summary for CRP

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]
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UniProt Comments for CRP

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: extracellular space; growth cone; extracellular region; filopodium

Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; cholesterol binding; low-density lipoprotein binding; virion binding; calcium ion binding

Biological Process: protein polymerization; defense response to Gram-positive bacterium; response to ethanol; wound healing; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; acute-phase response; response to hypoxia; opsonization; inflammatory response; complement activation, classical pathway; aging
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Research Articles on CRP

1. Elevated hs-CRP levels were associated with increased risk of disabling dementia in individuals with history of stroke but not in those without it.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CRP native protein

 Reference Product  PubMed Publications
 STAT3 native protein  >37 publications with CRP and STAT3
 C1S native protein  >12 publications with CRP and C1S
 C1R native protein  >12 publications with CRP and C1R
 APCS native protein  >11 publications with CRP and APCS
 LEP native protein  >10 publications with CRP and LEP
 FCGR2B native protein  >8 publications with CRP and FCGR2B
 FCGR2A native protein  >7 publications with CRP and FCGR2A
 C1QB native protein  >2 publications with CRP and C1QB

Pathways associated with CRP native protein

 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram

Diseases associated with CRP native protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >12214 publications with CRP and Inflammation
 Cardiovascular Diseases Antibodies  >8824 publications with CRP and Cardiovascular Diseases
 Infection Antibodies  >4796 publications with CRP and Infection
 Heart Diseases Antibodies  >4207 publications with CRP and Heart Diseases
 Metabolic Diseases Antibodies  >4023 publications with CRP and Metabolic Diseases
 Necrosis Antibodies  >3404 publications with CRP and Necrosis
 Myocardial Ischemia Antibodies  >3355 publications with CRP and Myocardial Ischemia
 Atherosclerosis Antibodies  >2986 publications with CRP and Atherosclerosis
 Obesity Antibodies  >2134 publications with CRP and Obesity
 Arthritis, Rheumatoid Antibodies  >2118 publications with CRP and Arthritis, Rheumatoid

Organs/Tissues associated with CRP native protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1509 publications with CRP and Liver
 Pancreas Antibodies  >159 publications with CRP and Pancreas
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