CRABP2 Antibody – Rabbit Polyclonal

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

Function: Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.

Subunit structure: Interacts with RXR and RARA

By similarity. Interacts with importin alpha. Ref.11

Subcellular location: Cytoplasm. Endoplasmic reticulum. Nucleus. Note: Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Ref.11 Ref.12

Induction: By retinoic acid.

Domain: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Post-translational modification: Sumoylated in response to retinoic acid binding, sumoylation is critical for dissociation from ER and subsequent nuclear translocation. Ref.14

Sequence similarities: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.