NP_001155313.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
100455 Da
NCBI Official Full Name
extracellular sulfatase Sulf-2 isoform a
NCBI Official Synonym Full Names
sulfatase 2
NCBI Official Synonym Symbols
NCBI Protein Information
extracellular sulfatase Sulf-2
UniProt Protein Name
Extracellular sulfatase Sulf-2
UniProt Synonym Gene Names
UniProt Entry Name
SULF2_HUMAN
NCBI Summary for Sulf2
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
UniProt Comments for Sulf2
Function: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.
Cofactor: Binds 1 calcium ion per subunit
By similarity.
Subcellular location: Endoplasmic reticulum
By similarity. Golgi apparatus › Golgi stack
By similarity. Cell surface
By similarity. Note: Also localized on the cell surface
By similarity.
Tissue specificity: Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
Post-translational modification: The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity
By similarity.
Sequence similarities: Belongs to the sulfatase family.
Biophysicochemical propertiespH dependence:Optimum pH is 7.0-8.0.
Sequence caution: The sequence AAH20962.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA86561.2 differs from that shown. Reason: Erroneous initiation. The sequence CAB61349.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on Sulf2
Precautions
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Products associated with Sulf2 peptide
Diseases associated with Sulf2 peptide
Organs/Tissues associated with Sulf2 peptide
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