Tubulin, Gamma Antibody – Rabbit Polyclonal

Globular tubulin subunits comprise the microtubule building block, with a/b-tubulin heterodimers forming the tubulin subunit common to all eukaryotic cells. As a critical part of the microtubule-organizing center (MTOC), the third member of the tubulin superfamily, y-tubulin, is required for microtubule nucleation as well as centrosome duplication and spindle assembly (1,2, reviewed in 3). y-tubulin forms complexes of two different sizes: y-tubulin small complex (y-TuSC) and the larger y-tubulin ring complex (y-TuRC). Each complex consists of a number of y-tubulin complex proteins (GCPs) with y-tubulin itself being considered GCP1. GCP2-6 all share sequence similarity in 5 different regions and it is thought that these areas could play a role in the proper folding of the proteins (4). y-TuSC is composed of two y-tubulin molecules as well as GCP2 and GCP3. y-TuRC is made up of a ring of multiple copies of y-TuSC in addition to GCP4, 5, and 6. Another protein, GCP-WD/NEDD1, which lacks sequence similarity with the other GCPs, associates with the y-TuRC. GCP-WD/NEDD1 has been shown to regulate localization of the y-TuSC to spindles and centrosomes (5-8). In mammals, phosphorylation of y-tubulin at Ser131 by SADB controls the activity of the y-TuRC. The hypothesis is that this phosphorylation stabilizes the protein in a conformation that stimulates centrosome amplification (9).

Small volumes of anti-Tubulin, gamma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS647709 is an antibody targeting Tubulin, gamma. Also known as Tubulin, gamma, CT (TUBG, Tubulin gamma 1 Chain, TUBG1, Tubulin gamma 2 Chain, TUBG2, Gamma 1 Tubulin, Gamma 2 Tubulin, Gamma Tubulin 1, Gamma Tubulin 2, Gamma Tubulin Complex Component 1, GCP 1, GCP-1, MGC131994, Xgam). Reactive in Human, Monkey, Mouse, Rat. Host: Rabbit.