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STXBP4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647854

MBS647854 is an antibody targeting STXBP4. Also known as STXBP4 (Syntaxin-binding Protein 4, Syntaxin 4-interacting Protein, STX4-interacting Protein, Synip). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
STXBP4, Monoclonal Antibody
Full Product Name
STXBP4 (Syntaxin-binding Protein 4, Syntaxin 4-interacting Protein, STX4-interacting Protein, Synip)
Product Gene Name
anti-STXBP4 antibody
Product Synonym Names
Anti -STXBP4 (Syntaxin-binding Protein 4, Syntaxin 4-interacting Protein, STX4-interacting Protein, Synip)
Immunogen Sequence
MIGVSFEEAK SIITRAKLST RLESAWEIAF IRQKSDNIQP ENLSCTSLIE ASGEYGPQAS TLSLFSSPPE ILIPKTSSTP KTNNDILSSC EIKTGYNKTV QIPITSENST VGLSNTDVAS AWTENYGLQE KISLNPSVRF KAEKLEMALN YLGIQPTKEQ HQALRQQVQA DSKGTVSFGD FVQVARNLFC LQLDEVNVGA HEISNILDSQ LLPCDSSEAD EMERLKCERD DALKEVNTLK WPGQN
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2B12
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human STXBP4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
61,662 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (53046119..53241646). Location: 17q22
OMIM
610415
3D Structure
ModBase 3D Structure for Q6ZWJ1
Immunogen
Full-length recombinant protein corresponding to aa1-246 from human STXBP4 (AAH41485) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-STXBP4 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-STXBP4 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-STXBP4 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Sandwich ELISA: The detection limit for recombinant GST tagged STXBP4 is ~0.1ng/ml as a capture antibody.

Western Blot (WB) of anti-STXBP4 antibody

Western Blot detection against Immunogen (53.06kD).
Mouse Anti-STXBP4 Monoclonal Antibody – Cat# MBS647854

Testing Data of anti-STXBP4 antibody

Detection limit for recombinant GST tagged STXBP4 is 0.1ng/ml as a capture antibody.
Mouse Anti-STXBP4 Monoclonal Antibody, Testing Data – Cat# MBS647854

Other Notes

Small volumes of anti-STXBP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for STXBP4. It may not necessarily be applicable to this product.

NCBI GI #
63999048
NCBI GeneID
252983
NCBI Accession #
NP_848604.3
UniProt Primary Accession #
Q6ZWJ1
UniProt Secondary Accession #
Q8IVZ5
UniProt Related Accession #
Q6ZWJ1
GenBank Nucleotide #
NM_178509.5
NCBI Official Full Name
syntaxin-binding protein 4
NCBI Official Synonym Full Names
syntaxin binding protein 4
NCBI Official Symbol
STXBP4
NCBI Official Synonym Symbols
Synip
UniProt Protein Name
Syntaxin-binding protein 4
UniProt Synonym Protein Names
Syntaxin 4-interacting protein
Protein Family
Syntaxin-binding protein
UniProt Gene Name
STXBP4
UniProt Synonym Gene Names
STX4-interacting protein; Synip
UniProt Entry Name
STXB4_HUMAN
NCBI Protein Information
syntaxin-binding protein 4; STX4-interacting protein; syntaxin 4 interacting protein; syntaxin 4-interacting protein

UniProt Comments for STXBP4

Function: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose

By similarity.

Subunit structure: Interacts with STX4A

By similarity.

Subcellular location: Cytoplasm

By similarity.

Post-translational modification: Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A

By similarity.

Sequence similarities: Contains 1 PDZ (DHR) domain.Contains 1 WW domain.
Show more

Research Articles on STXBP4

1. meta-analysis suggested that polymorphism STXBP4/COX11 rs6504950 variant was significantly associated with breast cancer risk; the A allele of rs6504950 decreased the risk of breast cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-STXBP4 antibody

 Reference Product  PubMed Publications
 SLC2A4 antibody  >5 publications with STXBP4 and SLC2A4
 VAMP2 antibody  >3 publications with STXBP4 and VAMP2
 SNAP23 antibody  >2 publications with STXBP4 and SNAP23
 AKT3 antibody  >2 publications with STXBP4 and AKT3
 AKT1 antibody  >2 publications with STXBP4 and AKT1
 AKT2 antibody  >2 publications with STXBP4 and AKT2
 STX4 antibody  >2 publications with STXBP4 and STX4

Pathways associated with anti-STXBP4 antibody

 Products by Pathway  Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
 Insulin-mediated Glucose Transport Pathway antibodies  Insulin-mediated Glucose Transport Pathway Diagram

Diseases associated with anti-STXBP4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with STXBP4 and Neoplasms
 Inflammation Antibodies  >1 publications with STXBP4 and Inflammation

Organs/Tissues associated with anti-STXBP4 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1 publications with STXBP4 and Pancreas
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