Rabbit Anti-SYTL4 Polyclonal Antibody – Cat# MBS647897

SYTL4 Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the SYTL4 antibody detected the SYTL4 protein (arrow).

SYTL4 Antibody – Rabbit Polyclonal

Name: SYTL4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS647897
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647897

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SYTL4, Polyclonal Antibody

Full Product Name

SYTL4, NT (SYTL4, Synaptotagmin-like protein 4, Exophilin-2, Granuphilin)

Product Gene Name

anti-Sytl4 antibody

Product Synonym Names

Anti -SYTL4, NT (SYTL4, Synaptotagmin-like protein 4, Exophilin-2, Granuphilin)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

75,900 Da

Chromosome Location

Chromosome: X; NC_005120.3 (104599736..104625454, complement). Location: Xq34

3D Structure

ModBase 3D Structure for Q8VHQ7

Immunogen

SYTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-34 amino acids from the N-terminal region of human SYTL4.

Product Categories/Family for anti-Sytl4 antibody

Antibodies; Abs to Syntaxin; Synaptotagmin; Synaptophysin

Applications Tested/Suitable for anti-Sytl4 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-Sytl4 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-Sytl4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Sytl4 purchase

MBS647897 is an antibody targeting Sytl4. Also known as SYTL4, NT (SYTL4, Synaptotagmin-like protein 4, Exophilin-2, Granuphilin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Sytl4. It may not necessarily be applicable to this product.

NCBI GI #

17939356

NCBI GeneID

140594

NCBI Accession #

NP_536335.1

UniProt Primary Accession #

Q8VHQ7

UniProt Secondary Accession #

Q8VHQ6

UniProt Related Accession #

Q8VHQ7

GenBank Nucleotide #

NM_080410.1

NCBI Official Full Name

synaptotagmin-like protein 4

NCBI Official Synonym Full Names

synaptotagmin-like 4

NCBI Official Symbol

Sytl4

UniProt Protein Name

Synaptotagmin-like protein 4

UniProt Synonym Protein Names

Exophilin-2; Granuphilin

Protein Family

Synaptotagmin-like protein

UniProt Gene Name

Sytl4

UniProt Entry Name

SYTL4_RAT

NCBI Protein Information

synaptotagmin-like protein 4; exophilin-2; granuphilin b; synaptotagmin-like 4 (granuphilin-a)

NCBI Summary for Sytl4

binds small GTP-binding protein Rab3 and SNARE-binding protein Munc-18; plays a role in pancreatic beta cell exocytosis; may also be involved in secretory vesicle docking [RGD, Feb 2006]

UniProt Comments for Sytl4

Function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner

By similarity.

Subunit structure: Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B

By similarity.

Subcellular location: Membrane; Peripheral membrane protein. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein. Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles. Ref.1

Tissue specificity: Detected in insulin-secreting cell lines.

Sequence similarities: Contains 2 C2 domains.Contains 1 FYVE-type zinc finger.Contains 1 RabBD (Rab-binding) domain.

Research Articles on Sytl4

1. Results support a role of PGC-1 in the regulation of insulin secretion via upregulation of UCP2 and granuphilin gene expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Sytl4 antibody

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>3 publications with Sytl4 and Autoimmune Diseases
Hyperglycemia Antibodies	>2 publications with Sytl4 and Hyperglycemia
Pancreatic Neoplasms Antibodies	>2 publications with Sytl4 and Pancreatic Neoplasms
Necrosis Antibodies	>2 publications with Sytl4 and Necrosis
Obesity Antibodies	>1 publications with Sytl4 and Obesity
Disease Models, Animal Antibodies	>1 publications with Sytl4 and Disease Models, Animal
Weight Loss Antibodies	>1 publications with Sytl4 and Weight Loss

Organs/Tissues associated with anti-Sytl4 antibody

Organ/Tissue Name	Pubmed Publications
Pituitary Gland Antibodies	>4 publications with Sytl4 and Pituitary Gland
Spleen Antibodies	>1 publications with Sytl4 and Spleen
Adrenal Gland Antibodies	>1 publications with Sytl4 and Adrenal Gland