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KDM6B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS647954

Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
JMJD3 (KDM6B), Polyclonal Antibody
Full Product Name
JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3)
Product Gene Name
anti-KDM6B antibody
Product Synonym Names
Anti -JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Human, mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
176,632 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (7737521..7758118). Location: 17p13.1
OMIM
611577
3D Structure
ModBase 3D Structure for O15054
Immunogen
Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 964~993 amino acids from the center region of mouse JMJD3.

Product Categories/Family for anti-KDM6B antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-KDM6B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-KDM6B antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100

Western Blot (WB) of anti-KDM6B antibody

Western blot analysis of anti-JMJD3 Center Pab (AP1022c) in Hela cell line lysates. JMJD3 Center(arrow) was detected using the purified Pab.
Rabbit Anti-KDM6B Polyclonal Antibody – Cat# MBS647954

Other Notes

Small volumes of anti-KDM6B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KDM6B purchase

MBS647954 is an antibody targeting KDM6B. Also known as JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KDM6B. It may not necessarily be applicable to this product.

NCBI GI #
14603031
NCBI GeneID
23135
NCBI Accession #
AAH09994.1
UniProt Primary Accession #
O15054
UniProt Secondary Accession #
Q96G33; C9IZ40
UniProt Related Accession #
O15054
NCBI Official Full Name
JMJD3 protein
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 6B
NCBI Official Symbol
KDM6B
NCBI Official Synonym Symbols
JMJD3
UniProt Protein Name
Lysine-specific demethylase 6B
UniProt Synonym Protein Names
JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B
Protein Family
Lysine-specific demethylase
UniProt Gene Name
KDM6B
UniProt Synonym Gene Names
JMJD3; KIAA0346
UniProt Entry Name
KDM6B_HUMAN
NCBI Protein Information
lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase

UniProt Comments for KDM6B

Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Ref.6 Ref.7

Cofactor: Ascorbate

By similarity. Ref.6Fe2+. Ref.6

Subunit structure: Interacts with TLE1

By similarity. Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B. Ref.6

Subcellular location: Nucleus

Probable Ref.6.

Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Ref.5

Sequence similarities: Belongs to the UTX family.Contains 1 JmjC domain.

Sequence caution: The sequence BAA21572.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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Research Articles on KDM6B

1. Data suggest that the suppression of different key inflammatory regulators through JMJD3-attenuation would evaluate potential therapeutic targets and to elucidate the molecular mechanism of JMJD3-knockdown (KD) dependent effects in THP-1 cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KDM6B antibody

 Reference Product  PubMed Publications
 SMAD3 antibody  >3 publications with KDM6B and SMAD3
 TBX21 antibody  >3 publications with KDM6B and TBX21
 SMAD2 antibody  >2 publications with KDM6B and SMAD2
 SMAD4 antibody  >2 publications with KDM6B and SMAD4
 ASCL1 antibody  >2 publications with KDM6B and ASCL1
 SMAD1 antibody  >1 publications with KDM6B and SMAD1
 HOXB1 antibody  >1 publications with KDM6B and HOXB1

Diseases associated with anti-KDM6B antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with KDM6B and Neoplasms
 Inflammation Antibodies  >9 publications with KDM6B and Inflammation
 Nervous System Diseases Antibodies  >7 publications with KDM6B and Nervous System Diseases
 Death Antibodies  >5 publications with KDM6B and Death
 Neural Tube Defects Antibodies  >5 publications with KDM6B and Neural Tube Defects
 Necrosis Antibodies  >4 publications with KDM6B and Necrosis
 Skin Diseases Antibodies  >4 publications with KDM6B and Skin Diseases
 Kidney Diseases Antibodies  >4 publications with KDM6B and Kidney Diseases
 Prostatic Diseases Antibodies  >3 publications with KDM6B and Prostatic Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with KDM6B and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-KDM6B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with KDM6B and Blood
 Embryonic Tissue Antibodies  >8 publications with KDM6B and Embryonic Tissue
 Bone Antibodies  >8 publications with KDM6B and Bone
 Skin Antibodies  >6 publications with KDM6B and Skin
 Brain Antibodies  >6 publications with KDM6B and Brain
 Prostate Antibodies  >4 publications with KDM6B and Prostate
 Kidney Antibodies  >4 publications with KDM6B and Kidney
 Heart Antibodies  >4 publications with KDM6B and Heart
 Lung Antibodies  >3 publications with KDM6B and Lung
 Pancreas Antibodies  >2 publications with KDM6B and Pancreas
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