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TPI1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648314

TPI1 is an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. More details

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Product Overview

Online Datasheet in PDF
Product Name
TPI1, Polyclonal Antibody
Full Product Name
TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI)
Product Gene Name
anti-TPI1 antibody
Product Synonym Names
Anti -TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human TPI1. Species sequence homology: Canine, mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
30,791 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (6976288..6980110). Location: 12p13
OMIM
190450
3D Structure
ModBase 3D Structure for P60174
Immunogen
Synthetic peptide corresponding to C-LKPEFVDIINAKQ from the C-terminal of human TPI1.

Product Categories/Family for anti-TPI1 antibody

Antibodies; Abs to Enzymes; Isomerase
Applications Tested/Suitable for anti-TPI1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-TPI1 antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: ELISA: 1:16,000
Western Blot: 0.01-0.03ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 5ug/ml

Immunohistochemistry (IHC) of anti-TPI1 antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with TPI1 antibody at 5ug/ml followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Goat Anti-TPI1 Polyclonal Antibody – Cat# MBS648314

Western Blot (WB) of anti-TPI1 antibody

Antibody staining (0.003ug/ml) of human liver lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-TPI1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS648314

Other Notes

Small volumes of anti-TPI1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPI1 purchase

MBS648314 is an antibody targeting TPI1. Also known as TPI1, CT (Triosephosphate Isomerase, TIM, Triose-phosphate Isomerase, TPI). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for TPI1. It may not necessarily be applicable to this product.

NCBI GI #
384475517
NCBI GeneID
7167
NCBI Accession #
NP_001244955.1
UniProt Primary Accession #
P60174
UniProt Secondary Accession #
P00938; Q6FHP9; Q6IS07; Q8WWD0; Q96AG5; B7Z5D8; D3DUS9
UniProt Related Accession #
P60174
GenBank Nucleotide #
NM_001258026.1
NCBI Official Full Name
triosephosphate isomerase isoform 3
NCBI Official Synonym Full Names
triosephosphate isomerase 1
NCBI Official Symbol
TPI1
NCBI Official Synonym Symbols
TIM; TPI
UniProt Protein Name
Triosephosphate isomerase
UniProt Synonym Protein Names
Triose-phosphate isomerase
UniProt Gene Name
TPI1
UniProt Synonym Gene Names
TPI; TIM
UniProt Entry Name
TPIS_HUMAN
NCBI Protein Information
triosephosphate isomerase; triose-phosphate isomerase

NCBI Summary for TPI1

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
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UniProt Comments for TPI1

Catalytic activity: D-glyceraldehyde 3-phosphate = glycerone phosphate.

Pathway: Carbohydrate biosynthesis; gluconeogenesis.Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.

Subunit structure: Homodimer. Ref.27 Ref.29

Post-translational modification: The initiator methionine for isoform 2 is removed.

Involvement in disease: Triosephosphate isomerase deficiency (TPI deficiency) [MIM:190450]: Autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection.Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities: Belongs to the triosephosphate isomerase family.

Sequence caution: The sequence AAB51316.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB59511.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH07086.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH07812.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH09329.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH11611.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH15100.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH17917.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH70129.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAH70129.1 differs from that shown. Reason: Sequence differs at the C-terminus.The sequence AAN86636.1 differs from that shown. Reason: Frameshift at position 23. The sequence BAG36090.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA49379.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on TPI1

1. we review the relationship between modified TPI and Alzheimer disease (AD), highlighting the relevance of this protein in AD pathology

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TPI1 antibody

 Reference Product  PubMed Publications
 PGK1 antibody  >9 publications with TPI1 and PGK1
 ENO1 antibody  >8 publications with TPI1 and ENO1
 GAPDH antibody  >7 publications with TPI1 and GAPDH
 GPI antibody  >3 publications with TPI1 and GPI
 PKM2 antibody  >2 publications with TPI1 and PKM2
 PKLR antibody  >1 publications with TPI1 and PKLR

Pathways associated with anti-TPI1 antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Fructose And Mannose Metabolism Pathway antibodies  Fructose And Mannose Metabolism Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram
 Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway antibodies  Gluconeogenesis, Oxaloacetate => Fructose-6P Pathway Diagram

Diseases associated with anti-TPI1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with TPI1 and Neoplasms
 Breast Neoplasms Antibodies  >3 publications with TPI1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >3 publications with TPI1 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >2 publications with TPI1 and Prostatic Neoplasms
 Hypertension Antibodies  >2 publications with TPI1 and Hypertension
 Carcinoma, Hepatocellular Antibodies  >1 publications with TPI1 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >1 publications with TPI1 and Weight Loss
 Abnormalities, Drug-Induced Antibodies  >1 publications with TPI1 and Abnormalities, Drug-Induced
 Liver Diseases Antibodies  >1 publications with TPI1 and Liver Diseases
 Kidney Diseases Antibodies  >1 publications with TPI1 and Kidney Diseases

Organs/Tissues associated with anti-TPI1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with TPI1 and Blood
 Brain Antibodies  >4 publications with TPI1 and Brain
 Muscle Antibodies  >3 publications with TPI1 and Muscle
 Eye Antibodies  >3 publications with TPI1 and Eye
 Prostate Antibodies  >2 publications with TPI1 and Prostate
 Kidney Antibodies  >2 publications with TPI1 and Kidney
 Heart Antibodies  >1 publications with TPI1 and Heart
 Liver Antibodies  >1 publications with TPI1 and Liver
 Testis Antibodies  >1 publications with TPI1 and Testis
 Esophagus Antibodies  >1 publications with TPI1 and Esophagus
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