Rabbit Anti-NRG4 Polyclonal Antibody – Cat# MBS648598

Western Blot analysis of NRG4 expression in transfected 293T cell line by NRG4 polyclonal antibody. Lane 1: NRG4 transfected lysate (12.7kD). Lane 2: Non-transfected lysate.

NRG4 Antibody – Rabbit Polyclonal

Name: NRG4 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS648598
Price: 970 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648598

The Pro-neuregulin-4, membrane-bound isoform contains 1 EGF-like domain and belongs to the neuregulin family. It is low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated… More details

$970 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NRG4, Polyclonal Antibody

Full Product Name

NRG4 (Pro-neuregulin-4, Membrane-bound Isoform, Pro-NRG4, DKFZp779N0541, DKFZp779N1944, HRG4)

Product Gene Name

anti-NRG4 antibody

Product Synonym Names

Anti -NRG4 (Pro-neuregulin-4, Membrane-bound Isoform, Pro-NRG4, DKFZp779N0541, DKFZp779N1944, HRG4)

Immunogen Sequence

MPTDHEEPCG PSHKSFCLNG GLCYVIPTIP SPFCRCVENY TGARCEEVFL PGSSIQTKSN LFEAFVALAV LVTLIIGAFY FLCRKGHFQR ASSVQYDINL VETSSTSAHH SHEQH

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human NRG4.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

12,722 Da

Chromosome Location

Chromosome: 15; NC_000015.9 (76234314..76304785, complement). Location: 15q24.2

OMIM

610894

3D Structure

ModBase 3D Structure for Q8WWG1

Immunogen

Full length human NRG4, aa1-115 (NP_612640.1).

Product Categories/Family for anti-NRG4 antibody

Antibodies; Abs to Growth Factors; Cytokines

Applications Tested/Suitable for anti-NRG4 antibody

Western Blot (WB)

Application Notes for anti-NRG4 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-NRG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NRG4 purchase

MBS648598 is an antibody targeting NRG4. Also known as NRG4 (Pro-neuregulin-4, Membrane-bound Isoform, Pro-NRG4, DKFZp779N0541, DKFZp779N1944, HRG4). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NRG4. It may not necessarily be applicable to this product.

NCBI GI #

112362942

NCBI GeneID

145957

NCBI Accession #

CAL35830.1

UniProt Primary Accession #

Q8WWG1

UniProt Secondary Accession #

A6NIE8

UniProt Related Accession #

Q8WWG1

NCBI Official Full Name

neuregulin 4

NCBI Official Synonym Full Names

neuregulin 4

NCBI Official Symbol

NRG4

NCBI Official Synonym Symbols

HRG4

UniProt Protein Name

Pro-neuregulin-4, membrane-bound isoform

Protein Family

Pro-neuregulin

UniProt Gene Name

NRG4

UniProt Synonym Gene Names

Pro-NRG4; NRG-4

UniProt Entry Name

NRG4_HUMAN

NCBI Protein Information

pro-neuregulin-4, membrane-bound isoform; pro-NRG4; heregulin 4

NCBI Summary for NRG4

The neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

UniProt Comments for NRG4

Function: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors

By similarity.

Subunit structure: Interacts with ERBB4

By similarity.

Subcellular location: Pro-neuregulin-4, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein

By similarity. Note: Does not seem to be active

By similarity.Neuregulin-4: Secreted

By similarity.

Domain: The cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing involves initial intracellular domain dimerization

By similarity.ERBB receptor binding is elicited entirely by the EGF-like domain

By similarity.

Post-translational modification: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form

By similarity.Extensive glycosylation precedes the proteolytic cleavage

By similarity.

Sequence similarities: Belongs to the neuregulin family.Contains 1 EGF-like domain.

Research Articles on NRG4

1. Pharmacological inhibition of PI3K/Akt signaling reversed the anti-apoptotic effects of NRG4, confirming the role of this cascade in NRG4-induced cell survival

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NRG4 antibody

Reference Product	PubMed Publications
NRG2 antibody	>8 publications with NRG4 and NRG2
NRG1 antibody	>7 publications with NRG4 and NRG1
ERBB4 antibody	>5 publications with NRG4 and ERBB4
ERBB2 antibody	>4 publications with NRG4 and ERBB2
EREG antibody	>3 publications with NRG4 and EREG
BTC antibody	>2 publications with NRG4 and BTC
HBEGF antibody	>1 publications with NRG4 and HBEGF
EGFR antibody	>1 publications with NRG4 and EGFR

Pathways associated with anti-NRG4 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies	Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
DAP12 Interactions Pathway antibodies	DAP12 Interactions Pathway Diagram
DAP12 Signaling Pathway antibodies	DAP12 Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies	Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
Downstream Signal Transduction Pathway antibodies	Downstream Signal Transduction Pathway Diagram
Downstream Signaling Of Activated FGFR Pathway antibodies	Downstream Signaling Of Activated FGFR Pathway Diagram
ErbB Receptor Signaling Network Pathway antibodies	ErbB Receptor Signaling Network Pathway Diagram
ErbB Signaling Pathway antibodies	ErbB Signaling Pathway Diagram

Diseases associated with anti-NRG4 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>9 publications with NRG4 and Neoplasms
Disease Models, Animal Antibodies	>2 publications with NRG4 and Disease Models, Animal
Growth Disorders Antibodies	>1 publications with NRG4 and Growth Disorders
Nervous System Diseases Antibodies	>1 publications with NRG4 and Nervous System Diseases
Neoplasm Metastasis Antibodies	>1 publications with NRG4 and Neoplasm Metastasis
Adenocarcinoma Antibodies	>1 publications with NRG4 and Adenocarcinoma
Liver Neoplasms Antibodies	>1 publications with NRG4 and Liver Neoplasms
Necrosis Antibodies	>1 publications with NRG4 and Necrosis

Organs/Tissues associated with anti-NRG4 antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>2 publications with NRG4 and Liver
Prostate Antibodies	>2 publications with NRG4 and Prostate
Bladder Antibodies	>1 publications with NRG4 and Bladder
Blood Antibodies	>1 publications with NRG4 and Blood
Intestine Antibodies	>1 publications with NRG4 and Intestine