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ANGPTL4, Coiled-Coil Domain (ANGPTL3) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS648612

ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and… More details

$595 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
ANGPTL4, coiled-coil domain (ANGPTL3), Monoclonal Antibody
Full Product Name
ANGPTL4, coiled-coil domain (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein)
Product Gene Name
Product Synonym Names
Anti -ANGPTL4, coiled-coil domain (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein)
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
Kairos4-397G
Host
Mouse
Form/Format
Supplied as a liquid in 0.2um-filtered PBS, pH 7.4. No preservative added.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes the coiled-coil domain (CCD) of human ANGPTL4. Detects a band of ~19kD by Western blot.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
53,637 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (63063158..63071976). Location: 1p31.3
OMIM
604774
3D Structure
ModBase 3D Structure for Q9Y5C1
Immunogen
Recombinant human coiled-coil domain of ANGPTL4.
Applications Tested/Suitable for anti-ANGPTL3 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ANGPTL3 antibody
Suitable for use in ELISA, Western Blot

Western Blot (WB) of anti-ANGPTL3 antibody

Western blot analysis using MBS648612 at 1:500 dilution.|1: Human ANGPTL4 (CCD) (DYKDDDDK-tagged).|2: Human ANGPTL4 (FLD) (DYKDDDDK-tagged).|3: Human ANGPTL4 (DYKDDDDK-tagged).|4: Human RBP4 (DYKDDDDK-tagged) (negative control).|5: Human ANGPTL3 (CCD) (DYKDDDDK-tagged).|6: Human ANGPTL2 (CCD) (DYKDDDDK-tagged).|7: Human ANGPTL5 (CCD) (DYKDDDDK-tagged).|8: Human ANGPTL3 (DYKDDDDK-tagged).
Mouse Anti-ANGPTL3 Monoclonal Antibody – Cat# MBS648612

Immunohistochemistry (IHC) of anti-ANGPTL3 antibody

Immunohistochemical staining of ANGPTL4 using MBS648612 in human placenta tissue (10ug/ml).|This antibody has been tested in immunohistochemistry, analyzed by an anatomic pathologist and validated for use in IHC applications against formalin-fixed, paraffin-embedded human tissues. The image shows the localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.
Mouse Anti-ANGPTL3 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS648612

Other Notes

Small volumes of anti-ANGPTL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANGPTL3 purchase

MBS648612 is an antibody targeting ANGPTL3. Also known as ANGPTL4, coiled-coil domain (Angiopoietin-like Protein 4, FIAF, Fasting-induced Adipose Factor, HFARP, Hepatic Fibrinogen/Angiopoietin-related Protein). Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ANGPTL3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
angiopoietin-related protein 3 preproprotein
NCBI Official Synonym Full Names
angiopoietin-like 3
NCBI Official Symbol
ANGPTL3
NCBI Official Synonym Symbols
ANL3; ANG-5; FHBL2; ANGPT5
UniProt Protein Name
Angiopoietin-related protein 3
UniProt Synonym Protein Names
Angiopoietin-5; ANG-5; Angiopoietin-like protein 3
UniProt Gene Name
ANGPTL3
UniProt Synonym Gene Names
ANGPT5; ANG-5
UniProt Entry Name
ANGL3_HUMAN
NCBI Protein Information
angiopoietin-related protein 3; angiopoietin 5

NCBI Summary for ANGPTL3

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
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UniProt Comments for ANGPTL3

Subunit structure: Interacts with C19orf80/ANGPTL8. Ref.9

Subcellular location: Secreted

By similarity.

Tissue specificity: Expressed principally in liver. Weakly expressed in kidney. Ref.1

Involvement in disease: Familial hypobetalipoproteinemia 2 (FHBL2) [MIM:605019]: A disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities: Contains 1 fibrinogen C-terminal domain.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ANGPTL3 antibody

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