Rabbit Anti-GRM8 Polyclonal Antibody – Cat# MBS6488046

The GRPRC1H C-term Pab is used in Western blot to detect GRPRC1H in mouse brain tissue lysate.

Metabotropic Glutamate Receptor 8 (GRM8) Antibody – Rabbit Polyclonal

Name: GRM8 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6488046
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6488046

MBS6488046 is an antibody targeting GRM8. Also known as Metabotropic Glutamate Receptor 8, CT (mGluR8, GPRC1H, MGLUR8, GRM8) (Azide free) (HRP). Reactive in Human, Mouse. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Metabotropic Glutamate Receptor 8 (GRM8), Polyclonal Antibody

Full Product Name

Metabotropic Glutamate Receptor 8, CT (mGluR8, GPRC1H, MGLUR8, GRM8) (Azide free) (HRP)

Product Gene Name

anti-GRM8 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

Purity/Purification

Purified by Protein G Affinity Chromatography.

Specificity

Recognizes human GRPRC1H. Species Crossreactivity: mouse.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

55,948 Da

OMIM

601116

3D Structure

ModBase 3D Structure for O00222

Immunogen

Synthetic peptide selected from the C-terminal region of human GRPRC1H (KLH).

Conjugate

HRP

Note

Preservative Free

Product Categories/Family for anti-GRM8 antibody

Antibodies; G Protein Receptors

Applications Tested/Suitable for anti-GRM8 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-GRM8 antibody

WB: 1:100-1:500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-GRM8 antibody

1. Malherbe, P., et al., Brain Res. Mol. Brain Res. 67(2):201-210 (1999). 2. Scherer, S.W., et al., Genomics 44(2):232-236 (1997). 3. Wu, S., et al., Brain Res. Mol. Brain Res. 53(1-2), 88-97 (1998).

Other Notes

Small volumes of anti-GRM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GRM8. It may not necessarily be applicable to this product.

NCBI GI #

187960067

NCBI GeneID

2918

NCBI Accession #

NP_000836

UniProt Primary Accession #

O00222

UniProt Secondary Accession #

O15493; O95945; O95946; Q3MIV9; Q52M02; Q6J165; A4D0Y3; B0FZ74; B0M0L0

UniProt Related Accession #

O00222

GenBank Nucleotide #

NM_000845

NCBI Official Full Name

metabotropic glutamate receptor 8 isoform a

NCBI Official Synonym Full Names

glutamate receptor, metabotropic 8

NCBI Official Symbol

GRM8

NCBI Official Synonym Symbols

GLUR8; mGlu8; GPRC1H; MGLUR8

UniProt Protein Name

Metabotropic glutamate receptor 8

Protein Family

Metabotropic glutamate receptor

UniProt Gene Name

GRM8

UniProt Synonym Gene Names

GPRC1H; MGLUR8; mGluR8

UniProt Entry Name

GRM8_HUMAN

NCBI Protein Information

metabotropic glutamate receptor 8

UniProt Comments for GRM8

mGluR8: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 3

Chromosomal Location of Human Ortholog: 7q31.3-q32.1

Cellular Component: presynaptic membrane; integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; group III metabotropic glutamate receptor activity; glutamate receptor activity

Biological Process: negative regulation of cAMP biosynthetic process; regulation of synaptic transmission, glutamatergic; visual perception; sensory perception of smell; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-GRM8 antibody

Products by Pathway	Pathway Diagram
Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway antibodies	Class C/3 (Metabotropic Glutamate/pheromone Receptors) Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway antibodies	GPCRs, Class C Metabotropic Glutamate, Pheromone Pathway Diagram
GPCRs, Other Pathway antibodies	GPCRs, Other Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram

Diseases associated with anti-GRM8 antibody

Disease Name	Pubmed Publications
Mental Disorders Antibodies	>7 publications with GRM8 and Mental Disorders
Personality Disorders Antibodies	>1 publications with GRM8 and Personality Disorders
Cognition Disorders Antibodies	>1 publications with GRM8 and Cognition Disorders
Autistic Disorder Antibodies	>1 publications with GRM8 and Autistic Disorder
Attention Deficit Disorder with Hyperactivity Antibodies	>1 publications with GRM8 and Attention Deficit Disorder with Hyperactivity

Organs/Tissues associated with anti-GRM8 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>3 publications with GRM8 and Brain
Lung Antibodies	>1 publications with GRM8 and Lung