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Nesfatin-1 (NUCB2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649146

MBS649146 is an antibody targeting NUCB2. Also known as Nesfatin-1, CT. Reactive in Human, Rat. Host: Rabbit. More details

$1055 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nesfatin-1 (NUCB2), Polyclonal Antibody
Full Product Name
Nesfatin-1, CT
Product Gene Name
anti-NUCB2 antibody
Product Synonym Names
Anti -Nesfatin-1, CT
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Supplied as a lyophilized powder. Reconstitute with sterile dH2O.
Purity/Purification
Serum
Serum
Specificity
Recognizes human Nesfatin-1. Species crossreactivity: rat.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
50,196 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (17281884..17371510). Location: 11p15.1
OMIM
608020
3D Structure
ModBase 3D Structure for P80303
Immunogen
Synthetic peptide corresponding to human Nesfatin-1.

Product Categories/Family for anti-NUCB2 antibody

Antibodies; Abs to Obesity Proteins
Applications Tested/Suitable for anti-NUCB2 antibody
Immunohistochemistry (IHC)
Application Notes for anti-NUCB2 antibody
Suitable for use in Immunohistochemistry.

Western Blot (WB) of anti-NUCB2 antibody

Western blot analysis fo rat brain tissue lysate using MBS649146 at 1:700 dilution.
Rabbit Anti-NUCB2 Polyclonal Antibody – Cat# MBS649146

Other Notes

Small volumes of anti-NUCB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NUCB2. It may not necessarily be applicable to this product.

NCBI GI #
4826870
NCBI GeneID
4925
NCBI Accession #
NP_005004.1
UniProt Primary Accession #
P80303
UniProt Secondary Accession #
Q8NFT5; A8K642; D3DQX5
UniProt Related Accession #
P80303
GenBank Nucleotide #
NM_005013.2
NCBI Official Full Name
nucleobindin-2
NCBI Official Synonym Full Names
nucleobindin 2
NCBI Official Symbol
NUCB2
NCBI Official Synonym Symbols
NEFA
UniProt Protein Name
Nucleobindin-2
UniProt Synonym Protein Names
DNA-binding protein NEFA; Gastric cancer antigen Zg4; Prepronesfatin
Protein Family
Nucleobindin
UniProt Gene Name
NUCB2
UniProt Synonym Gene Names
NEFA
UniProt Entry Name
NUCB2_HUMAN
NCBI Protein Information
nucleobindin-2; nesfatin-1; prepronefastin; prepronesfatin; nucleobinding 2; DNA-binding protein NEFA; gastric cancer antigen Zg4

NCBI Summary for NUCB2

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

UniProt Comments for NUCB2

Function: Calcium-binding protein. May have a role in calcium homeostasis.Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance

By similarity.

Subcellular location: Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted Ref.8. Endoplasmic reticulum

By similarity. Nucleus envelope

By similarity. Note: Golgi retention is mediated by its N-terminal region. Ref.8Nesfatin-1: Secreted Ref.8.

Tissue specificity: Predominantly expressed in spleen, testis and normal stomach. Ref.3

Polymorphism: Deletion of Gln-402 is frequent.

Miscellaneous: NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region.

Sequence similarities: Belongs to the nucleobindin family.Contains 2 EF-hand domains.
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Research Articles on NUCB2

1. Loss of fat mass may decrease serum nesfatin-1 level in lung cancer patients with weight loss.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NUCB2 antibody

 Reference Product  PubMed Publications
 POMC antibody  >9 publications with NUCB2 and POMC
 ERAP1 antibody  >2 publications with NUCB2 and ERAP1

Diseases associated with anti-NUCB2 antibody

 Disease Name  Pubmed Publications
 Weight Gain Antibodies  >10 publications with NUCB2 and Weight Gain
 Disease Models, Animal Antibodies  >3 publications with NUCB2 and Disease Models, Animal
 Neoplasms Antibodies  >3 publications with NUCB2 and Neoplasms
 Necrosis Antibodies  >3 publications with NUCB2 and Necrosis
 Liver Diseases Antibodies  >3 publications with NUCB2 and Liver Diseases
 Carcinoma Antibodies  >2 publications with NUCB2 and Carcinoma
 Inflammation Antibodies  >2 publications with NUCB2 and Inflammation
 Learning Disorders Antibodies  >1 publications with NUCB2 and Learning Disorders
 Weight Loss Antibodies  >1 publications with NUCB2 and Weight Loss
 Fibrosis Antibodies  >1 publications with NUCB2 and Fibrosis

Organs/Tissues associated with anti-NUCB2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >50 publications with NUCB2 and Brain
 Stomach Antibodies  >17 publications with NUCB2 and Stomach
 Blood Antibodies  >15 publications with NUCB2 and Blood
 Pancreas Antibodies  >14 publications with NUCB2 and Pancreas
 Liver Antibodies  >9 publications with NUCB2 and Liver
 Adipose Tissue Antibodies  >7 publications with NUCB2 and Adipose Tissue
 Pituitary Gland Antibodies  >4 publications with NUCB2 and Pituitary Gland
 Heart Antibodies  >4 publications with NUCB2 and Heart
 Muscle Antibodies  >4 publications with NUCB2 and Muscle
 Intestine Antibodies  >3 publications with NUCB2 and Intestine
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