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CDC23 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649871

CDC23 shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and… More details

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Product Overview

Online Datasheet in PDF
Product Name
CDC23, Polyclonal Antibody
Full Product Name
CDC23, NT (CDC23, ANAPC8, Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, Cyclosome subunit 8)
Product Gene Name
anti-CDC23 antibody
Product Synonym Names
Anti -CDC23, NT (CDC23, ANAPC8, Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, Cyclosome subunit 8)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Purified
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
68,834 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (137523337..137549032, complement). Location: 5q31
OMIM
603462
3D Structure
ModBase 3D Structure for Q9UJX2
Immunogen
CDC23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141~170 amino acids from the Center region of human CDC23.

Product Categories/Family for anti-CDC23 antibody

Antibodies; Abs to Cell Division Cycle (CDC)
Applications Tested/Suitable for anti-CDC23 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CDC23 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
Immunohistochemistry: 1:50-100

Western Blot (WB) of anti-CDC23 antibody

Western blot analysis of CDC23 antibody (N-term) in HL60 cell line lysates(35ug/lane). CDC23 (arrow) was detected using the purified Pab.
Rabbit Anti-CDC23 Polyclonal Antibody – Cat# MBS649871

Immunohistochemistry (IHC) of anti-CDC23 antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with CDC23 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CDC23 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS649871

Other Notes

Small volumes of anti-CDC23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDC23 purchase

MBS649871 is an antibody targeting CDC23. Also known as CDC23, NT (CDC23, ANAPC8, Cell division cycle protein 23 homolog, Anaphase-promoting complex subunit 8, Cyclosome subunit 8). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CDC23. It may not necessarily be applicable to this product.

NCBI GI #
4519431
NCBI GeneID
8697
NCBI Accession #
BAA75628.1
UniProt Primary Accession #
Q9UJX2
UniProt Secondary Accession #
O75433; Q53FN2; Q9BS73; A8K6E5; B4E3A2; B7WP05; D3DQB7
UniProt Related Accession #
Q9UJX2
NCBI Official Full Name
CDC23
NCBI Official Synonym Full Names
cell division cycle 23
NCBI Official Symbol
CDC23
NCBI Official Synonym Symbols
APC8; CUT23; ANAPC8
UniProt Protein Name
Cell division cycle protein 23 homolog
UniProt Synonym Protein Names
Anaphase-promoting complex subunit 8; APC8; Cyclosome subunit 8
Protein Family
Anaphase-promoting complex
UniProt Gene Name
CDC23
UniProt Synonym Gene Names
ANAPC8; APC8
UniProt Entry Name
CDC23_HUMAN
NCBI Protein Information
cell division cycle protein 23 homolog; cyclosome subunit 8; cell division cycle 23 homolog; anaphase promoting complex subunit 8; anaphase-promoting complex subunit 8

NCBI Summary for CDC23

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
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UniProt Comments for CDC23

Function: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Ref.13

Pathway: Protein modification; protein ubiquitination.

Subunit structure: The APC/C is composed of at least 12 subunits. Ref.9

Post-translational modification: Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis. Ref.11

Sequence similarities: Belongs to the APC8/CDC23 family.Contains 9 TPR repeats.

Sequence caution: The sequence AAC70920.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH05258.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH10944.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH17713.1 differs from that shown. Reason: Erroneous initiation. The sequence AAS99353.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA75628.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD96970.1 differs from that shown. Reason: Erroneous initiation. The sequence BAF84299.1 differs from that shown. Reason: Erroneous initiation.
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Research Articles on CDC23

1. CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDC23 antibody

 Reference Product  PubMed Publications
 CDC16 antibody  >24 publications with CDC23 and CDC16
 CDC27 antibody  >19 publications with CDC23 and CDC27
 CDC20 antibody  >18 publications with CDC23 and CDC20
 CCNB1 antibody  >5 publications with CDC23 and CCNB1

Pathways associated with anti-CDC23 antibody

 Products by Pathway  Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram

Diseases associated with anti-CDC23 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with CDC23 and Neoplasms
 Breast Neoplasms Antibodies  >2 publications with CDC23 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >2 publications with CDC23 and Ovarian Neoplasms
 Gonadal Disorders Antibodies  >2 publications with CDC23 and Gonadal Disorders
 Carcinoma, Hepatocellular Antibodies  >2 publications with CDC23 and Carcinoma, Hepatocellular
 Ovarian Diseases Antibodies  >2 publications with CDC23 and Ovarian Diseases
 Liver Neoplasms, Experimental Antibodies  >1 publications with CDC23 and Liver Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with CDC23 and Liver Diseases
 Adenocarcinoma Antibodies  >1 publications with CDC23 and Adenocarcinoma
 Death Antibodies  >1 publications with CDC23 and Death

Organs/Tissues associated with anti-CDC23 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with CDC23 and Liver
 Bone Antibodies  >1 publications with CDC23 and Bone
 Thyroid Antibodies  >1 publications with CDC23 and Thyroid
 Lung Antibodies  >1 publications with CDC23 and Lung
 Kidney Antibodies  >1 publications with CDC23 and Kidney
 Blood Antibodies  >1 publications with CDC23 and Blood
 Spleen Antibodies  >1 publications with CDC23 and Spleen
 Vascular Antibodies  >1 publications with CDC23 and Vascular
 Brain Antibodies  >1 publications with CDC23 and Brain
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