Mouse Anti-crbn Polyclonal Antibody – Cat# MBS649923

Western Blot analysis of CRBN expression in transfected 293T cell line by MBS649923. Lane 1: CRBN transfected lysate (48.62kD). Lane 2: Non-transfected lysate.

crbn Antibody – Mouse Polyclonal

Name: crbn Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649923
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649923

Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In… More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CRBN, Polyclonal Antibody

Full Product Name

CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358)

Product Gene Name

anti-crbn antibody

Product Synonym Names

Anti -CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358)

Immunogen Sequence

MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS ALLPTIPDTE DEISPDKVIL CL

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human CRBN.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

49,095 Da

Chromosome Location

Chromosome: 6; NC_007117.5 (40387662..40397691, complement). Location: chromosome: 6

3D Structure

ModBase 3D Structure for Q68EH9

Immunogen

Full length human CRBN, aa1-442 (NP_057386.2).

Product Categories/Family for anti-crbn antibody

Antibodies; Abs to Neuroscience

Applications Tested/Suitable for anti-crbn antibody

Western Blot (WB)

Application Notes for anti-crbn antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-crbn antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for crbn purchase

MBS649923 is an antibody targeting crbn. Also known as CRBN (Protein Cereblon, AD-006, DKFZp781K0715, MGC27358). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for crbn. It may not necessarily be applicable to this product.

NCBI GI #

182890566

NCBI GeneID

445491

NCBI Accession #

AAI64733.1

UniProt Primary Accession #

Q68EH9

UniProt Related Accession #

Q68EH9

NCBI Official Full Name

Crbn protein

NCBI Official Synonym Full Names

cereblon

NCBI Official Symbol

crbn

NCBI Official Synonym Symbols

zgc:92404

UniProt Protein Name

Protein cereblon

Protein Family

Protein cereblon

UniProt Gene Name

crbn

UniProt Synonym Gene Names

zcrbn

UniProt Entry Name

CRBN_DANRE

NCBI Protein Information

protein cereblon; zcrbn

UniProt Comments for crbn

Function: Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. May also be involved in memory and learning. Ref.2

Pathway: Protein modification; protein ubiquitination.

Subunit structure: Component of a DCX (DDB1-CUL4-X-box) protein ligase complex

By similarity.

Subcellular location: Cytoplasm

By similarity. Nucleus

By similarity.

Tissue specificity: Highly expressed in brain, head, vasculature otic vesicles and developing pectoral fins. Ref.2

Disruption phenotype: Specific defects in fin and otic vesicle development. Ref.2

Miscellaneous: Specifically binds thalidomide. Thalidomide teratogenic activity may be a consequence of crbn-binding. Overexpression of a mutant protein abolishing thalidomide-binding does not affect otic vesicle size (Ref.2).

Sequence similarities: Belongs to the CRBN family.Contains 1 Lon domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-crbn antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>10 publications with crbn and Nervous System Diseases
Mental Retardation, Autosomal Recessive 2 Antibodies	>7 publications with crbn and Mental Retardation, Autosomal Recessive 2
Congenital Abnormalities Antibodies	>6 publications with crbn and Congenital Abnormalities
Cardiovascular Diseases Antibodies	>6 publications with crbn and Cardiovascular Diseases
Abnormalities, Multiple Antibodies	>3 publications with crbn and Abnormalities, Multiple
Abnormalities, Drug-Induced Antibodies	>2 publications with crbn and Abnormalities, Drug-Induced
Learning Disorders Antibodies	>2 publications with crbn and Learning Disorders
Memory Disorders Antibodies	>1 publications with crbn and Memory Disorders
Nervous System Malformations Antibodies	>1 publications with crbn and Nervous System Malformations
Cognition Disorders Antibodies	>1 publications with crbn and Cognition Disorders

Organs/Tissues associated with anti-crbn antibody

Organ/Tissue Name	Pubmed Publications
Whole Body Antibodies	>1 publications with crbn and Whole Body