Mouse Anti-AP1M2 Polyclonal Antibody – Cat# MBS649959

Western Blot analysis of AP1M2 expression in transfected 293T cell line by AP1M2 polyclonal antibody. Lane 1: AP1M2 transfected lysate (46.53KD). Lane 2: Non-transfected lysate.

AP1M2 Antibody – Mouse Polyclonal

Name: AP1M2 Antibody; Polyclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS649959
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS649959

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the… More details

$880 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AP1M2, Polyclonal Antibody

Full Product Name

AP1M2 (AP-1 Complex Subunit mu-2, AP-mu Chain Family Member mu1B, Adaptor Protein Complex AP-1 mu-2 Subunit, Adaptor-related Protein Complex 1 mu-2 Subunit, Clathrin Assembly Protein Complex 1 Medium Chain 2, Golgi Adaptor HA1/AP1 Adaptin mu-2 Subunit, Mu

Product Gene Name

anti-Ap1m2 antibody

Product Synonym Names

Anti -AP1M2 (AP-1 Complex Subunit mu-2, AP-mu Chain Family Member mu1B, Adaptor Protein Complex AP-1 mu-2 Subunit, Adaptor-related Protein Complex 1 mu-2 Subunit, Clathrin Assembly Protein Complex 1 Medium Chain 2, Golgi Adaptor HA1/AP1 Adaptin mu-2 Subunit, Mu

Immunogen Sequence

MSASAVFILD VKGKPLISRN YKGDVAMSKI EHFMPLLVQR EEEGALAPLL SHGQVHFLWI KHSNLYLVAT TSKNANASLV YSFLYKTIEV FCEYFKELEE ESIRDNFVIV YELLDELMDF GFPQTTDSKI LQEYITQQSN KLETGKSRVP PTVTNAVSWR SEGIKYKKNE VFIDVIESVN LLVNANGSVL LSEIVGTIKL KVFLSGMPEL RLGLNDRVLF ELTGRSKNKS VELEDVKFHQ CVRLSRFDND RTISFIPPDG DFELMSYRLS TQVKPLIWIE SVIEKFSHSR VEIMVKAKGQ FKKQSVANGV EISVPVPSDA DSPRFKTSVG SAKYVPERNV VIWSIKSFPG GKEYLMRAHF GLPSVEKEEV EGRPPIGVKF EIPYFTVSGI QVRYMKIIEK SGYQALPWVR YITQSGDYQL RTS

Clonality

Polyclonal

Isotype

IgG

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Recognizes human AP1M2.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

48,137 Da

Chromosome Location

Chromosome: 9; NC_000075.6 (21295457..21312333, complement). Location: 9 A3; 9 7.76 cM

3D Structure

ModBase 3D Structure for Q9WVP1

Immunogen

Full length human AP1M2, aa1-423 (NP_005489).

Product Categories/Family for anti-Ap1m2 antibody

Antibodies; Abs to Adapter Proteins

Applications Tested/Suitable for anti-Ap1m2 antibody

Western Blot (WB)

Application Notes for anti-Ap1m2 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-Ap1m2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ap1m2 purchase

MBS649959 is an antibody targeting Ap1m2. Also known as AP1M2 (AP-1 Complex Subunit mu-2, AP-mu Chain Family Member mu1B, Adaptor Protein Complex AP-1 mu-2 Subunit, Adaptor-related Protein Complex 1 mu-2 Subunit, Clathrin Assembly Protein Complex 1 Medium Chain 2, Golgi Adaptor HA1/AP1 Adaptin mu-2 Subunit, Mu. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Ap1m2. It may not necessarily be applicable to this product.

NCBI GI #

160333508

NCBI GeneID

11768

NCBI Accession #

NP_033808.2

UniProt Primary Accession #

Q9WVP1

UniProt Secondary Accession #

Q99LA4; Q9CWP7

UniProt Related Accession #

Q9WVP1

GenBank Nucleotide #

NM_009678.2

NCBI Official Full Name

AP-1 complex subunit mu-2 isoform 2

NCBI Official Synonym Full Names

adaptor protein complex AP-1, mu 2 subunit

NCBI Official Symbol

Ap1m2

NCBI Official Synonym Symbols

mu1B; [m]1B; D9Ertd818e

UniProt Protein Name

AP-1 complex subunit mu-2

UniProt Synonym Protein Names

AP-mu chain family member mu1B; Adaptor protein complex AP-1 subunit mu-2; Adaptor-related protein complex 1 subunit mu-2; Clathrin assembly protein complex 1 mu-2 medium chain 2; Golgi adaptor HA1/AP1 adaptin mu-2 subunit; Mu-adaptin 2; Mu1B-adaptin

Protein Family

AP-1 complex

UniProt Gene Name

Ap1m2

UniProt Entry Name

AP1M2_MOUSE

NCBI Protein Information

AP-1 complex subunit mu-2; mu-adaptin 2; mu1B-adaptin; AP-mu chain family member mu1B; adaptor protein complex AP-1 mu-2 subunit; golgi adaptor HA1/AP1 adaptin mu-2 subunit; adaptor-related protein complex 1 mu-2 subunit; adaptor-related protein complex AP-1, mu 2 subunit; clathrin assembly protein complex 1 medium chain 2

UniProt Comments for Ap1m2

Function: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

Subunit structure: Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3). Ref.5

Subcellular location: Golgi apparatus. Cytoplasmic vesicle › clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.

Post-translational modification: Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals

By similarity.

Sequence similarities: Belongs to the adaptor complexes medium subunit family.Contains 1 MHD (mu homology) domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Ap1m2 antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Pathway antibodies	Lysosome Pathway Diagram
Lysosome Vesicle Biogenesis Pathway antibodies	Lysosome Vesicle Biogenesis Pathway Diagram
MHC Class II Antigen Presentation Pathway antibodies	MHC Class II Antigen Presentation Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Trans-Golgi Network Vesicle Budding Pathway antibodies	Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with anti-Ap1m2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with Ap1m2 and Neoplasms
Endometrial Neoplasms Antibodies	>1 publications with Ap1m2 and Endometrial Neoplasms
Hyperplasia Antibodies	>1 publications with Ap1m2 and Hyperplasia
Necrosis Antibodies	>1 publications with Ap1m2 and Necrosis
Kidney Neoplasms Antibodies	>1 publications with Ap1m2 and Kidney Neoplasms
Neoplasms, Experimental Antibodies	>1 publications with Ap1m2 and Neoplasms, Experimental
Kidney Diseases Antibodies	>1 publications with Ap1m2 and Kidney Diseases
Inflammation Antibodies	>1 publications with Ap1m2 and Inflammation

Organs/Tissues associated with anti-Ap1m2 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>4 publications with Ap1m2 and Kidney
Brain Antibodies	>1 publications with Ap1m2 and Brain
Intestine Antibodies	>1 publications with Ap1m2 and Intestine