Interferon Tau, Ovine (IFNT2) Active Protein

Function: Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.

Subcellular location: Secreted. Note: Secreted into the uterine lumen.

Tissue specificity: Constitutively and exclusively expressed in the mononuclear cells of the extraembryonic trophectoderm.

Developmental stage: Major secretory product synthesized by the bovine conceptus between days 15 and 25 of pregnancy.

Polymorphism: There seems to be four variants of IFN-tau 1: A, B (shown here), C and D.

Miscellaneous: IFN-tau genes are intronless. They evolved from IFN-omega genes in the ruminantia suborder and have continued to duplicate independently in different lineages of the ruminantia. They code for proteins very similar in sequence but with different biological potency and pattern of expression.

Sequence similarities: Belongs to the alpha/beta interferon family. IFN-alphaII subfamily.