Mouse Anti-IFNAR1 Monoclonal Antibody – Cat# MBS6507782

Flow Cytometry analysis of IFN-alpha/beta R1 in human U927 cell line using MBS6507782.

IFNAR1 Antibody – Mouse Monoclonal

Name: IFNAR1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6507782
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6507782

Type I interferons (IFN-a, IFN-b, IFN-o) bind to the type I IFN receptor, also known as the IFN-a/b receptor. This receptor is composed of 2 chains, IFN- a/b R1 and R2. More details

$1090 / 100 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFNAR1 (Interferon alpha/beta Receptor 1, IFN-R-1, IFN-alpha/beta Receptor 1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, CRF2-1, Type I Interferon Receptor 1, IFNAR), Monoclonal Antibody

Full Product Name

Product Gene Name

anti-IFNAR1 antibody

Clonality

Monoclonal

Isotype

IgG1

Clone Number

12K109

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with Allophycocyanin (APC).

Purity/Purification

Affinity Purified

Concentration

~0.01mg/ml (lot specific)

Specificity

Recognizes human IFNAR1. Does not react with recombinant human IFN-gR1, recombinant human IFN-gR2, recombinant mouse IFN-a/bR2, recombinant human IL-10Rb, recombinant human IL-10Ra, or recombinant human IL-20Rb

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

107450

3D Structure

ModBase 3D Structure for P17181

Immunogen

Recombinant protein corresponding to Lys28-Lys436 from human IFNAR1 expressed in Sf-21 cells

Conjugation

APC

Absorption

620-650nm

Emission

660-670nm

Product Categories/Family for anti-IFNAR1 antibody

Antibodies-Primary; Antibodies-Interferon

Applications Tested/Suitable for anti-IFNAR1 antibody

Flow Cytometry (FC/FACS)

Application Notes for anti-IFNAR1 antibody

Flow Cytometry: 10ul to label 1x10e6 cells using human U937 histiocytic lymphoma cell line

Other Notes

Small volumes of anti-IFNAR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNAR1 purchase

MBS6507782 is an antibody targeting IFNAR1. Also known as IFNAR1 (Interferon alpha/beta Receptor 1, IFN-R-1, IFN-alpha/beta Receptor 1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, CRF2-1, Type I Interferon Receptor 1, IFNAR)(APC). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNAR1. It may not necessarily be applicable to this product.

NCBI Accession #

AAA52730

UniProt Primary Accession #

P17181

UniProt Protein Name

Interferon alpha/beta receptor 1

UniProt Synonym Protein Names

Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1

Protein Family

Interferon alpha/beta receptor

UniProt Gene Name

IFNAR1

UniProt Synonym Gene Names

IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1

UniProt Entry Name

INAR1_HUMAN

UniProt Comments for IFNAR1

IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; interferon receptor activity; interferon-alpha/beta receptor activity

Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; response to virus; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-1 beta secretion; JAK-STAT cascade; interferon type I biosynthetic process; defense response to virus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.