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Interferon Regulatory Factor 5 (IRF5) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6507785

Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Interferon Regulatory Factor 5 (IRF5), Polyclonal Antibody
Full Product Name
Interferon Regulatory Factor 5 (IRF5)
Product Gene Name
anti-IRF5 antibody
Product Synonym Names
Interferon Regulatory Factor 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Rat
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity/Purification
Affinity Purified
Specificity
Recognizes endogenous levels of total mouse Interferon Regulatory Factor 5 at 60kD. Species Crossreactivity: rat
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
498
OMIM
phenotype 612251
3D Structure
ModBase 3D Structure for Q13568
Immunogen
Synthetic peptide corresponding to residues surrounding Ser172 of mouse Interferon Regulatory Factor 5 (Q13568).

Product Categories/Family for anti-IRF5 antibody

Antibodies-Primary; Antibodies-Interferon
Applications Tested/Suitable for anti-IRF5 antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-IRF5 antibody
Western Blot: 1:1000
Immunoprecipitation: 1:100

Western Blot (WB) of anti-IRF5 antibody

Western Blot analysis of extracts from A20 and BaF3 cells using MBS6507785 (rodent specific).
Rabbit Anti-IRF5 Polyclonal Antibody – Cat# MBS6507785

Western Blot (WB) of anti-IRF5 antibody

Western Blot analysis of extracts from Raw264.7 cells, untreated or LPS-treated (1ug/ml for 6 hours), M12.4.1 cells and A20 cells, using MBS6507785 (rodent specific).
Rabbit Anti-IRF5 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6507785

Other Notes

Small volumes of anti-IRF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IRF5 purchase

MBS6507785 is an antibody targeting IRF5. Also known as Interferon Regulatory Factor 5 (IRF5). Reactive in Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for IRF5. It may not necessarily be applicable to this product.

NCBI GI #
20178305
NCBI GeneID
3663
NCBI Accession #
Q13568.2
UniProt Primary Accession #
Q13568
UniProt Secondary Accession #
Q1A7B4; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0; A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54
UniProt Related Accession #
Q13568
NCBI Official Full Name
Interferon regulatory factor 5
NCBI Official Synonym Full Names
interferon regulatory factor 5
NCBI Official Symbol
IRF5
NCBI Official Synonym Symbols
SLEB10
UniProt Protein Name
Interferon regulatory factor 5
Protein Family
Interferon regulatory factor
UniProt Gene Name
IRF5
UniProt Synonym Gene Names
IRF-5
UniProt Entry Name
IRF5_HUMAN
NCBI Protein Information
interferon regulatory factor 5

NCBI Summary for IRF5

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]
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UniProt Comments for IRF5

IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of apoptosis; response to muramyl dipeptide; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; response to peptidoglycan; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production

Disease: Systemic Lupus Erythematosus, Susceptibility To, 10; Inflammatory Bowel Disease 14
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Research Articles on IRF5

1. Unlike other studies, this study found no association of the rs2004640 SNP with SLE among Han Chinese. It did however interact with SNPS in ETS1, STAT4, and IKZF1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IRF5 antibody

 Reference Product  PubMed Publications
 IRF3 antibody  >40 publications with IRF5 and IRF3
 MYD88 antibody  >18 publications with IRF5 and MYD88
 TRAF6 antibody  >6 publications with IRF5 and TRAF6
 TBK1 antibody  >4 publications with IRF5 and TBK1
 STAT2 antibody  >4 publications with IRF5 and STAT2
 ISG15 antibody  >3 publications with IRF5 and ISG15
 IRF6 antibody  >3 publications with IRF5 and IRF6

Pathways associated with anti-IRF5 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram

Diseases associated with anti-IRF5 antibody

 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >143 publications with IRF5 and Lupus Erythematosus, Systemic
 Arthritis, Rheumatoid Antibodies  >59 publications with IRF5 and Arthritis, Rheumatoid
 Inflammation Antibodies  >56 publications with IRF5 and Inflammation
 Necrosis Antibodies  >25 publications with IRF5 and Necrosis
 Scleroderma, Systemic Antibodies  >22 publications with IRF5 and Scleroderma, Systemic
 Fibrosis Antibodies  >13 publications with IRF5 and Fibrosis
 Liver Diseases Antibodies  >11 publications with IRF5 and Liver Diseases
 Colitis, Ulcerative Antibodies  >8 publications with IRF5 and Colitis, Ulcerative
 Atherosclerosis Antibodies  >7 publications with IRF5 and Atherosclerosis
 Kidney Diseases Antibodies  >7 publications with IRF5 and Kidney Diseases

Organs/Tissues associated with anti-IRF5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >105 publications with IRF5 and Blood
 Bone Antibodies  >13 publications with IRF5 and Bone
 Bone Marrow Antibodies  >10 publications with IRF5 and Bone Marrow
 Spleen Antibodies  >9 publications with IRF5 and Spleen
 Connective Tissue Antibodies  >8 publications with IRF5 and Connective Tissue
 Kidney Antibodies  >8 publications with IRF5 and Kidney
 Lung Antibodies  >7 publications with IRF5 and Lung
 Mouth Antibodies  >6 publications with IRF5 and Mouth
 Brain Antibodies  >5 publications with IRF5 and Brain
 Lymph Node Antibodies  >3 publications with IRF5 and Lymph Node
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